urokinase-type plasminogen activator
Interaction between plasminogen activator inhibitor type 1 (PAI 1) bound to fibrin and either tissue type plasminogen activator (t PA) or urokinase type plasminogen activator (u PA) Binding of t PA/PAI 1 complexes to fibrin mediated by both the finger and the kringle 2 domain of t PA
... by urokinase-type plasminogen activator ...by plasminogen activator inhibitor type 1 (PAI-1) that is either present in plasma or bound to fibrin, present in a ...activate ...
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Urokinase-type plasminogen activator receptor promotes proliferation and invasion with reduced cisplatin sensitivity in malignant mesothelioma
... elevated urokinase-type plasminogen activator receptor (uPAR; Plaur) expression in rat tissues, which was associated with poor ...of urokinase-type plasminogen ...
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Soluble urokinase-type plasminogen activator receptor is a novel biomarker predicting acute exacerbation in COPD
... Soluble urokinase-type plasminogen activator receptor (suPAR) levels increase in acute viral and bacterial infections and in diseases involving chronic ...
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A role for urokinase-type plasminogen activator in human immunodeficiency virus type 1 infection of macrophages.
... Urokinase-type plasminogen activator (uPA), a proteinase which activates plasminogen by cleaving at -CPGR2V-, was shown to cleave the V3 loop in recombinant gp120 of human ...
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Significance of the urokinase-type plasminogen activator and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models
... soluble urokinase-type plasminogen activator (uPA) receptor (suPAR) in approximately two-thirds of patients with FSGS, and suPAR levels were predictive of FSGS recur- rence in transplanted ...
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Acceleration of the thrombin inactivation of single chain urokinase type plasminogen activator (pro urokinase) by thrombomodulin
... chain urokinase-type plasminogen activator (scu-PA) by thrombin were investigated by incubating scu-PA with varying concentrations of human thrombin, in both the absence and presence of ...
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Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor
... Total hepatic uPA is similar with and without uPAR Binding of uPA to uPAR has been shown to increase pro- teolytic activation in vitro [40]. Thus, to explore whether loss of uPAR alters the level of hepatic uPA, we ...
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Urokinase type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvement
... rheumatoid arthritis tissue [3]. Several different cell types present in arthritic joints can produce PAs and their inhibitors in vitro, including in response to inflam- matory cytokines [4-11]. We and other workers have ...
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Coordinated expression of the vitronectin receptor and the urokinase type plasminogen activator receptor in metastatic melanoma cells
... Integrin alpha v beta 3 is a marker of progression in malignant melanoma. Previously we reported that human melanoma cells derived from regional lymph node metastases had increased alpha v beta 3-mediated adhesion to ...
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Urokinase type plasminogen activator and arthritis progression: contrasting roles in systemic and monoarticular arthritis models
... Joint damage in arthritis, with cartilage and bone destruction, is believed to be mediated (at least in part) through proteases, such as MMPs and plasmin [8]. u- PA-generated plasmin activity may play a pivotal role in ...
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Receptor-bound urokinase-type plasminogen activator in human colon cancer invasion and metastasis
... Statement Acknowledgements Abstract Abbreviations List of Figures CHAPTER 1 INTRODUCTION 1.1 Mechanisms of Tumour Invasion and Metastasis 1.1.1 Major steps in the process of metastasis 1[r] ...
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Immunohistochemical localization of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and α2-antiplasmin in human corneal perforation: a case report
... In our case, interestingly, α 2AP expression was observed mostly in the corneal stromal opacity area presumably affected with fibrosis and was barely seen in the ulcer- ation area.. Doub[r] ...
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Be Active or Not: the Relative Contribution of Active and Passive Tumor Targeting of Nanomaterials
... Malignant tumor (cancer) remains as one of the deadliest diseases throughout the world, despite its overall mortality drops. Nanomaterials (NMs) have been widely studied as diagnostic and/or therapeutic agents for ...
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Correlation of biomarkers for parasite burden and immune activation with acute kidney injury in severe falciparum malaria
... soluble urokinase–type plasminogen activator receptor (suPAR) reflects the systemic level of cell surface urokinase-type plasminogen activator receptor (uPAR) ex- ...
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Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2α contributes to human bladder cancer cell survival
... and urokinase type plasminogen activator (uPA), resulting in p27 induction, cell cycle arrest at G1 phase and cell growth suppression in human urothelial carcinoma cell lines expressing ...
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Enhanced bioreduction-responsive diselenide-based dimeric prodrug nanoparticles for triple negative breast cancer therapy
... that urokinase-type plasminogen activator receptor (uPAR) plays a major role in invasive cancer cells and also shows high expression in TNBC [32, 33], a uPAR ligand, uPA peptide (sequence: ...
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Urokinase Plasminogen Activator Receptor (uPAR) Targeted Nuclear Imaging and Radionuclide Therapy
... Urokinase-type plasminogen activator receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein. Besides regulating proteolysis, uPAR could also activate many intracellular ...
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Organization, evolution and functions of the human and mouse Ly6/uPAR family genes
... Ly6/urokinase-type plasminogen activator receptor-related protein 1 (SLURP1) is expressed in a variety of cells including immune cells [75], sensory neu- rons [76], and epithelial cells ...
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Current insights into matrix metalloproteinases and glioma progression: transcending the degradation boundary
... Specific Interference of urokinase-type plasminogen activator receptor and matrix metallopro- teinase-9 gene expression induced by double-stranded RNA results in decreased invasion, tu[r] ...
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Factors influencing the cell adhesion and invasion capacity of Mycoplasma gallisepticum
... collagen type IV (C5533), collagen type V (C3567) and porcine heparin (H3149), as well as plasminogen (P7999), urokinase plasminogen activa- tor ...fibronectins, plasminogen, and ...
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