UTR, untranslated region
Translation from the 5′ Untranslated Region (UTR) of mRNA 1 Is Repressed, but That from the 5′ UTR of mRNA 7 Is Stimulated in Coronavirus-Infected Cells
... Coronaviruses are positive-strand RNA viruses with a ge- nome of approximately 30 kb, the largest known among RNA viruses. Both virus genome replication and transcription take place in the cytoplasm (reviewed in ...
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1 IRES trans-acting factors, key actors of the stress
... IRES Internal ribosome entry site ITAF IRES trans-acting factor UTR Untranslated region. PTB Pyrimidine tract binding protein ER Endoplasmic reticulum[r] ...
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Comparative analysis of hepatitis C virus phylogenies from coding and non coding regions: the 5' untranslated region (UTR) fails to classify subtypes
... (5' UTR) regions of whole- genome HCV sequences for consistent classification of viral subtypes into distinct genetic groups, or clades, with the aim of evaluating their suitability for genotype and subtype ...5' ...
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Novel mutations in the ferritin-L iron-responsive element that only mildly impair IRP binding cause hereditary hyperferritinaemia cataract syndrome
... IRP: Iron regulatory protein; IRE: Iron responsive element; UTR: Untranslated region; FTL: Ferritin L; HHCS: Hereditary Hyperferritinaemia cataract syndrome; EMSA: Electrophoretic mobili[r] ...
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Genome wide computational analysis of potential long noncoding RNA mediated DNA:DNA:RNA triplexes in the human genome
... stretches; UTR: untranslated region; CDS: coding DNA sequence; TF: transcription factors; lncRNAs: long noncod- ing RNAs; R motif: purine motif; Y motif: pyrimidine motif; M motif: purine– pyrimidine ...
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Comparison of single nucleotide polymorphisms in the 3′ untranslated region of HLA G in placentas between spontaneous preterm birth and preeclampsia
... inflammations/infections, and preeclampsia [7, 9, 22–24]. Kusanovic et al. investigated sHLA-G in amniotic fluid and found that it was elevated in preterm parturition and associated with intraamniotic ...
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A Six-Nucleotide Segment within the 3′ Untranslated Region of Hibiscus Chlorotic Ringspot Virus Plays an Essential Role in Translational Enhancement
... ⴕ UTR enhances the expression of gRNA and sgRNA of ...3⬘ UTR could differentially enhance the translation of various ORFs on gRNA and ...3⬘ UTR, in wheat germ extracts resulted in the detection of ...
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The emerging world of microRNAs
... 3’-untranslated region (UTR) of target mRNAs and generally negatively regulate gene expression post-transcriptionally, although at least one human miRNA has recently been found to act positively on ...
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Multifunctional roles of leader protein of foot-and-mouth disease viruses in suppressing host antiviral responses
... 5′ untranslated region; 3′-UTR: 3′ untranslated region; ORF: the open reading frame; eIF4G: eukaryotic translation initiation factor 4 gamma; NF-κB: nuclear factor kappa B; NEMO: NF-κB ...
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Functionalization of an antisense small RNA
... ′ untranslated region (5′ UTR) of a messenger RNA (mRNA) to modulate gene expression ...′ UTR allows base pairing of ribosomal binding site (RBS), which then becomes inactivated ...
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Polypyrimidine Tract-Binding Protein Binds to the Complementary Strand of the Mouse Hepatitis Virus 3′ Untranslated Region, Thereby Altering RNA Conformation
... ⴕ untranslated region (3 ⴕ -UTR) of the viral genome is also required for subgenomic mRNA transcription; deletion of nucleotides (nt) 270 to 305 from the 3 ⴕ -UTR completely abolished ...
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Regulation of thrombospondin-1 expression through AU-rich elements in the 3′UTR of the mRNA
... TSP-1 expression is highly regulated in vitro and in vivo by a number of specific factors [4, 7] and during different tissue processes such as development [8], folliculogenesis [9], inflammation, and tissue repair [10]. ...
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Regulation of dendritic cell activation by microRNA let 7c and BLIMP1
... 3′ untranslated region (UTR) of Blimp1 also contains a putative target sequence of let-7c based on the database of miRNA analysis (Sanger Center miRNA ...3′ UTR, Luc-3′UTR/Blimp1, into ...
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Association between Dopamine Transporter Gene (DAT1) Polymorphisms and Eating Disorders with Binge Eating Behavior
... prime untranslated region variable number of tandem repeat) of the Dopamine Transporter 1 ( DAT1 ) gene and ED with binge eating behavior ...coding region of the DAT1 gene also associate with ...
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Molecular Comparison of Three Different Regions of the Genome of Infectious Bronchitis Virus Field Isolates and Vaccine Strains
... Rapid detection and differentiation of infectious bronchitis virus (IBV) involved in the disease outbreak is very important for controlling disease and developing new vaccines. In the present study, three regions of the ...
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Circulating microRNA-21 is an early predictor of ROS-mediated damage in subjects with high risk of developing diabetes and in drug-naïve T2D
... The use of biomarkers is increasing, and technical advancements allow more accurate identification of processes involved in pathological progression. Glucose intolerance is generally established after a 75-g glucose load ...
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A Highly Conserved Sequence in the 3′-Untranslated Region of the Drosophila Adh Gene Plays a Functional Role in Adh Expression
... Phylogenetic analysis identified a highly conserved eight-base sequence (AAGGCTGA) within the 39- untranslated region (UTR) of the Drosophila alcohol dehydrogenase gene, Adh. To examine the ...
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A miR-SNP of the <em>XPO5</em> gene is associated with advanced non-small-cell lung cancer
... 3′ untranslated region (3′ UTR) of the miRNA processing machinery gene XPO5 was examined in 112 advanced non-small-cell lung cancer (NSCLC) patients to evaluate its association with cancer ...
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Multiple functions of a glioblastoma fusion oncogene
... 3′–untranslated region (3′- UTR) of FGFR3 is lost, releasing FGFR3 signaling from miR-99a–depen- dent inhibition and greatly enhancing tumor progression relative to WT ...
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Original Article MicroRNA-27a-3p promotes the metastasis and epithelial-mesenchymal transition of gastric cancer via targeting RUNX1
... 3-untranslated region (UTR) of RUNX1 in gastric cancer, and the inverse correlation was observed be- tween the expressions of miR-27a-3p and RUNX1 mRNA in primary GC ...
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