uveal melanoma
Expression of EpCAM in uveal melanoma
... Background: Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults, and nearly 40% of UM will develop metastasis that will ultimately lead to ...
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Choroidal hemangioma: MR findings and differentiation from uveal melanoma
... of uveal melanoma showed, in the vast majority, hyper- intensity on T1-weighted SE images and hypointen- sity on FSE T2-weighted images with respect to the ...with uveal melanoma, the tumor ...
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Association of specific chromosome alterations with tumour phenotype in posterior uveal melanoma
... In uveal melanoma most alter- ations yield unbalanced rearrangements and would therefore fall into the category of secondary, possibly unrelated changes (Johansson et al, ...larger uveal melanomas as ...
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Brachytherapy for patients with uveal melanoma: historical perspectives and future treatment directions
... for uveal melanoma (UM) for over 100 ...Ocular Melanoma Study confirmed in 2001 that globe-preserving episcleral brachytherapy for UM was safe and effective, demonstrating no survival difference with ...
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Effect of Genistein on vasculogenic mimicry formation by human uveal melanoma cells
... for uveal melanoma C918 cells cultured on the three-dimensional type I collagen gels after exposed to ...human uveal melanoma C918 cells were established to assess the number of VM using ...
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<p>Blood Biomarkers of Uveal Melanoma: Current Perspectives</p>
... of uveal melanoma (UM) is a controversial ...cutaneous melanoma and UM cell lines, circulating tumor cells, microRNAs (miRNA), and circulating DNA, and how each may be critical in the development of ...
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<p>The Economic Value of MR-Imaging for Uveal Melanoma</p>
... Objective: Uveal melanoma (UM) is the most common primary intra-ocular tumour. Treatment is determined by tumour size and location. Generally, smaller tumours are eligible for brachytherapy unless they are ...
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Adjuvant Dendritic Cell Vaccination in High-Risk Uveal Melanoma.
... Uveal melanoma (UM) is the most common primary intraocular malignancy in adults with an annual incidence of 4 to 10 per million in the Caucasian population. The 5-year overall survival (OS) rate is ...
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MicroRNA dysregulation in uveal melanoma: a new player enters the game
... invasive uveal melanoma cell lines ...both uveal melanoma cells and clinical specimens ...26 uveal melanomas ...cutaneous melanoma cell line G361 and the uveal ...
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A case-control study: occupational cooking and the risk of uveal melanoma
... disease, uveal melanoma is the most common primary intraocular malignancy in adults, with an incidence rate of up to 8 per 1000 000 person years (age-standardized, world standard) in Europe ...for ...
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Case-control study on uveal melanoma (RIFA): rational and design
... referred to the Division of Ophthalmology, University of Duisburg-Essen during the recruitment period, are aged 20–74 years at diagnosis, are living in Germany, and are capable to complete the interview in German. The ...
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Modeling of Human Uveal Melanoma in Zebrafish Xenograft Embryos
... M ETHODS . Uveal melanoma cell lines generated from primary tumors (92.1, Mel270) and metastases (OMM2.3, OMM2.5, OMM1) were injected into the yolk of 2-day-old zebrafish embryos. After 6 days, ...
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Association of tumor and plasma microRNA expression with tumor monosomy-3 in patients with uveal melanoma
... in uveal melanoma progression [32, ...in uveal melanoma tumors when compared to normal choroid, miR-20a, miR-21, and miR-106a, were also measured to examine the possibility that increases may ...
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FGF2 promotes metastasis of uveal melanoma cells via store-operated calcium entry
... Abstract: Uveal melanoma (UM), the most common primary intraocular malignancy in adults, is highly metastatic and associated with dismal ...of melanoma and other ...on melanoma cell migration ...
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The antihelminthic drug niclosamide effectively inhibits the malignant phenotypes of uveal melanoma in vitro and in vivo
... Figure 6. Niclosamide eliminates uveal melanoma cancer stem-like cells with Wnt/β-catenin signaling pathway blocked. (A) The UM cells were incubated with niclosamide (2 μmol/L) for 48 h, and then inoculated ...
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Evaluation of <em>p53</em> gene expression and prognosis characteristics in uveal melanoma cases
... The aim of this research was to evaluate the effects of the expression of p53 protein in uveal melanoma on the prognosis after the local excision. Studies have found that p53 mutant protein is highly ...
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Heterogeneity revealed by integrated genomic analysis uncovers a molecular switch in malignant uveal melanoma
... Gene expression profiles as well as genomic imbalances are correlated with disease progression in uveal melanoma (UM). We integrated expression and genomic profiles to obtain insight into the oncogenic ...
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Combined immune checkpoint blockade for metastatic uveal melanoma: a retrospective, multi-center study
... Uveal melanoma (UM) is a malignant tumor of the eye that originates from the pigment cells of the choroid layer or the ciliary body which is clinically and biologic- ally distinct from cutaneous ...
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Proton beam radiotherapy in the management of uveal melanoma: Clinical experience in Scotland
... Methods: A retrospective review was undertaken on all patients receiving PBRT for uveal melanoma (1994–2005). Data obtained included: gender, past ocular/medical history, age, presenting complaint(s), ...
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Targeting MDMX and PKC delta to improve current uveal melanoma therapeutic strategies
... Uveal melanoma (UM) is the most frequent ocular cancer in adults, accounting for ~5% of the total melanoma incidence. Although the primary tumor is well treatable, patients frequently develop ...
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