β-amyloid
Decreased levels of soluble amyloid β protein precursor and β amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus
... as β-amyloid protein (A β 42) have not been assessed at all in this ...CSF-A β 42 levels reflect either increased deposition of this molecule in senile plaques and cerebral blood vessels ...of ...
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β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice
... A β deposition to the ...A β levels [12,13], whereas others have discovered no differ- ence [10,11], with multiple methodological approaches used across ...A β was unchanged with induction of ...
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Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
... The APP gene is alternatively spliced to produce three major isoforms of 695, 751, and 770 amino acids in length. The two longer APP isoforms, APP751 and APP770, both contain a 56 amino acid Kunitz Protease Inhibitor ...
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Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab
... unprocessed amyloid precursor protein (APP) (hypothesized to be a desirable attribute in a clinical candidate), and is pre- served in bapineuzumab (humanized 3D6, version 2), as reported ...compacted β- ...
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Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
... A β generation but not AICD ...to β actin ...A β 40 and A β 42 were determined by sandwich ELISA and normalized to the levels of PS1 CTF in the corresponding ...A β amyloid ...
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Decreasing the expression of PICALM reduces endocytosis and the activity of β secretase: Implications for Alzheimer's disease
... Background: Polymorphisms in the gene for phosphatidylinositol binding clathrin assembly protein (PICALM), an endocytic-related protein, are associated with a small, increased risk of developing Alzheimer’s disease (AD), ...
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Cerebrospinal fluid soluble TREM2 in aging and Alzheimer’s disease
... A β : amyloid beta; A β 42: amyloid beta 1 – 42; A β PP: A β precursor protein; CHO: Chinese hamster ovary; CSF: cerebrospinal fluid; CT: computed tomography; DAP12: DNAX ...
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Addition of the Aβ42/40 ratio to the cerebrospinal fluid biomarker profile increases the predictive value for underlying Alzheimer’s disease dementia in mild cognitive impairment
... A β : Amyloid beta; A β 40: 40-aminoacid isoform of amyloid beta; A β 42: 42-aminoacid isoform of amyloid beta; BLAD: Bateria de Lisboa para Avaliação de Demência (Lisbon Battery ...
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Aqueous extract from the Withania somnifera leaves as a potential anti-neuroinflammatory agent: a mechanistic study
... nM β-amyloid ...and β-amyloid-exposed culture group inhibited activation of the microglia as was seen by normal morphology of these ...and β-amyloid-induced BV-2 cells were ...
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Clinical validation of the Lumipulse G cerebrospinal fluid assays for routine diagnosis of Alzheimer’s disease
... positive β-amyloid plaques marker (either reduced Aβ42 or reduced Aβ42/Aβ40 ratio) in combination with a positive marker of fibrillary tau (in- creased p-Tau ...
12
Induced pluripotent stem cells in Alzheimer’s disease: applications for disease modeling and cell-replacement therapy
... BSI: β -secretase inhibitor; aGSK-3 β : active glycogen synthase kinase-3 β ; AD: Alzheimer ’ s disease; A β : Amyloid- β (A β ); APP: Amyloid precursor protein; ...
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Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice
... A β : Amyloid-beta; A β PP swe : Amyloid-beta precursor protein, human Swedish mutation; AD: Alzheimer ’ s disease; C3B6: Mice with a combination C3H/He and C57BL/6 background; CAT: Catalase; ...
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Stepping closer to treating Alzheimer’s disease patients with BACE1 inhibitor drugs
... of β -amyloid peptide (A β ) is widely believed to induce pathological changes and cause dementia in brains of AD ...of amyloid precursor protein (APP) at the β -secretase ...A β ...
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Cross-talk of membrane lipids and Alzheimer-related proteins
... extracellular β - amyloid plaques and intracellular neurofibrillary tangles in the ...the amyloid β -peptide (A β ), tangles are formed by fibrillar forms of the microtubule associated ...
12
Cerebral amyloid angiopathy-related inflammation: a case report presenting with a rare variant in SORL1 gene
... to β-amyloid (Aβ) protein in the blood vessel walls [5] and likely responsive to corticosteroid or other immunosuppres- sive agents ...9]. Amyloid-related imaging abnormalities (ARIA) represent the ...
6
Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer’s disease mouse model
... A β : amyloid β peptide; AD: Alzheimer ’ s disease; APH-1: anterior pharynx- defective 1; APP: amyloid β precursor protein; BACE-1: β -site amyloid precursor protein ...
10
Alzheimer’s disease and immunotherapy: what is wrong with clinical trials?
... A β production and secretion abilities, after which we chose an IgL-A β× 4-Fc-IL-4 vaccine (YM3711) for further ...anti-A β antibody production and reduce A β were ...A β pE3-42 ...
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Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
... vascular amyloid or senile plaques from AD and Down’s syndrome patients, the identifi cation of APP was a logical step forward ...vascular amyloid - the chromo somal location of APP also strongly argued in ...
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RIG-1 receptor expression in the pathology of Alzheimer’s disease
... Infection of cells by viruses and microorganisms acti- vates innate immune inflammatory responses. The initial sensing of infection is mediated by pattern recognition receptors, which include TLRs, RIG-I-like receptors ...
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Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy
... in amyloid-β assembly inhib- ...reduce amyloid-β plaque pathology in Alzheimer’s disease model mice ...ing amyloid-β aggregation in vitro ...
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