β-amyloid precursor protein
Modulation of β-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
... A β in vitro either by binding to Aβ itself or Aβ complexed to apoE, activated α 2 M, or lactoferrin ...in amyloid plaques in AD brains and also in fibrillar amyloid plaques in a mouse model of AD ...
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Phorbol Esters Affect Multiple Steps in β-Amyloid Precursor Protein Trafficking and Amyloid β-Protein Production
... Because endocytic processing of ,BPP from the cell surface is a major pathway of AP3 produc- tion, the effect of PKC activation by phorbol 12,1 3-dibu- tyrate (PDBu) on endocytic traffic[r] ...
8
Decreased levels of soluble amyloid β protein precursor and β amyloid protein in cerebrospinal fluid of patients with systemic lupus erythematosus
... elevated protein levels are found in some but not all patients with CNS lupus ...as β-amyloid protein (A β 42) have not been assessed at all in this ...condition. Protein tau is ...
8
The role of APP and BACE1 trafficking in APP processing and amyloid-β generation
... the amyloid-β protein (Aβ) was isolated from brains with amyloid depositon and it was subsequently identified as the core protein of neuritic plaques ...from amyloid-β ...
8
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
... AICD: Amyloid intracellular domain; APP: Amyloid precursor protein; A β : Amyloid β ; BACE1: β -secretase; CHO: Chinese hamster ovary cell line; CHX: Cycloheximide ...
24
Prophylactic melatonin significantly reduces Alzheimer’s neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPPswe/PS1 mice
... A β : Amyloid-beta; A β PP swe : Amyloid-beta precursor protein, human Swedish mutation; AD: Alzheimer ’ s disease; C3B6: Mice with a combination C3H/He and C57BL/6 background; ...
21
Amyloid precursor protein modulates β-catenin degradation
... induces β-catenin phosphorylation at Ser 33 , Ser 37 , and Thr 41 (S33/37/T41) residues, which is a prerequisite for β- catenin ubiquitinylation and proteasomal ...of β-catenin resulted in the ...
10
Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
... In retrospect it is not surprising that almost all APP mutations causative of FAD cluster around the sites of proteolytic processing by the β-secretase and γ-secretase enzymes, releasing the Aβ peptides into the ...
14
Stepping closer to treating Alzheimer’s disease patients with BACE1 inhibitor drugs
... of β -amyloid peptide (A β ) is widely believed to induce pathological changes and cause dementia in brains of AD ...of amyloid precursor protein (APP) at the β -secretase ...
11
Cerebral amyloid angiopathy-related inflammation: a case report presenting with a rare variant in SORL1 gene
... precursor protein (APP) processing [13, 18]. A β levels are mainly determined by the kinetic of SorLA and APP interaction according to the mathematic model which supports the fact that APP sorting ...
6
The Alzheimer’s disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway
... of amyloid-β (Aβ) in amyloid deposits in AD brain and trans- genic animal models of AD [16, 19, ...A β (mixture of different lengths and aggregation states) and ApoE (isoform and lipidation ...
13
Calcium/calmodulin-dependent kinase II and Alzheimer’s disease
... aggregated amyloid-β (Aβ) peptides [2–4] and hyperphosphorylated tau protein [5–8], ...the amyloid precursor protein (APP) by β- and γ-secretases, can aggregate into a ...
7
Association between total-Tau and brain atrophy one year after first-ever stroke
... of amyloid precursor protein (APP) metabolites ...upregulate β- secretase activity associated with amyloid deposition and neuritic plaque formation ...associated protein tau ...
6
Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer’s disease mouse model
... A β : amyloid β peptide; AD: Alzheimer ’ s disease; APH-1: anterior pharynx- defective 1; APP: amyloid β precursor protein; BACE-1: β -site amyloid ...
10
Decreasing the expression of PICALM reduces endocytosis and the activity of β secretase: Implications for Alzheimer's disease
... cellular β-C-terminal fragment (β-CTF) and secreted sAPPβ (APP fragments produced by β-secretase cleav- age) were significantly reduced but Aβ40 itself was not ...1 protein and mRNA expression ...
17
Axonal and synaptic pathology in Alzheimer’s disease
... fibrillar β-amyloid (Aβ) as well as intracellular neurofibrillary tangles comprised of hyperphosphorylated tau, that give rise to characteristic dystrophic neurites and neuropil threads, respectively, have ...
321
Amyloid precursor protein and amyloid precursor-like protein 2 in cancer
... Amyloid precursor protein (APP) is an evolutionarily conserved protein with two homologues in mammals: amyloid precursor-like protein 1 (APLP1) and amyloid ...
15
Adjusting the compass: new insights into the role of angiogenesis in Alzheimer’s disease
... Cramer and colleagues [77] interprets bexarotene acting on RXRs to upregulate transcription of ApoE, a protein that is implicated in Aβ plaque degradation. The improve- ment in hippocampal function is ultimately ...
9
RIG-1 receptor expression in the pathology of Alzheimer’s disease
... 3-42 Aβ species have been shown to be the most preva- lent form of Aβ peptides present in early and later stages of human AD amyloid pathology [18]. Since we found that levels of RIG-1 expression are elevated in ...
9
CYP2C19 variant mitigates Alzheimer disease pathophysiology in vivo and postmortem
... Similarly, the cognitive composite scores from the 2 cohorts have some differences that should be considered. There are also some intrinsic characteristics of the samples that have to be taken into account: (1) the ...
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