β-arrestin
Original Article β-arrestin 2 is associated with multidrug resistance in breast cancer cells through regulating MDR1 gene expression
... of β-arrestin 2 in tumor viability and metastasis ...that β-arrestin 2 directly regulated LPA1- induced migration and invasion in breast cancer MDA-MB-231 cell lines ...that ...
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Expression and light dependent translocation of β arrestin in the visual system of the terrestrial slug Limax valentianus
... anti- β -arrestin antibody ...anti- β -arrestin antibody (900 μ l, ...recombinant β -arrestin protein covalently attached to NHS- activated Sepharose 4 Fast Flow beads (100 μ l ...
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Glycogen synthase kinase 3 is essential for β arrestin 2 complex formation and lithium sensitive behaviors in mice
... Overexpression of Gsk3b reverses lithium-sensitive behaviors. Rescue of a gene knockout or drug-induced phenotype by restoring activ- ity of the putative target provides strong support for the hypoth- esis that the ...
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β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
... of β -arr1KO utilizing LoxP-Cre recombineering β-arr1flox/flox mice were generated using recombineering techniques as previously described for the generation of β-arrestin 2 flox/flox mice ...
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β Arrestin–mediated β1 adrenergic receptor transactivation of the EGFR confers cardioprotection
... via β-arrestin–mediated cytoprotective pathways, would represent a novel class of agents that could be developed for multiple members of the 7 transmembrane receptor ...
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PDZ Protein Regulation of β-arrestin Recruitment and GPCR Trafficking
... activated arrestin undergo a 20° rotation from the central axis and this twisting facilitates interaction with the receptor (Fig ...of β-arrestin. This also may serve to prevent ...
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Monoclonal anti β1 adrenergic receptor antibodies activate G protein signaling in the absence of β arrestin recruitment
... wild-type β 1 AR recep- tors by two antibodies, thus demonstrating species cross-reactivity by showing similar functional ...(G) β-arrestin independent cAMp ...type β 1 AR receptor, dose ...
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Nicotine induces cell proliferation by β arrestin–mediated activation of Src and Rb–Raf 1 pathways
... Interestingly, β-arrestin seems to be vital for nicotine-medi- ated activation of Src and cell ...the β-arrestin family have been shown to serve as scaffold proteins that recruit a broad ...
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Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling
... of β-arrestin (βarr)-dependent βAR signaling in the absence of G protein activation has the capacity to impart survival benefits in cardiomyocytes [4, 5], but the ability to selectively engage this pathway ...
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Prognostic significance of USP33 in advanced colorectal cancer patients: new insights into β-arrestin-dependent ERK signaling
... deubiquitinate β-arrestin2, subsequently block the internalization of SDF- 1-stimulated CXCR4, and disrupt β-arrestin-dependent ERK ...of β-arrestin-dependent signaling have been ...
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Hepatic β arrestin 2 is essential for maintaining euglycemia
... protein β-arrestin 2 in hepatocytes of adult mice results in greatly increased hepatic GCGR signaling, leading to striking deficits in glucose ...hepatocyte-specific β-arrestin 2 deficiency ...
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Clenbuterol Induces Cell Cycle Arrest in C2C12 Myoblasts by Delaying p27 Degradation through β-arrestin 2 Signaling
... Membranes were blocked with 5% nonfat milk or BSA and probed with primary antibodies and horseradish peroxidase-conjugated secondary antibodies. Blots were developed with lumi-light Western blotting substrate detection ...
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β Arrestin 2 regulates the development of allergic asthma
... lacking β-arrestin-2, a G protein–coupled receptor regulatory protein, demonstrate impaired migration in ...the β-arrestin-2 gene do not accumulate T lymphocytes in their airways, nor do they ...
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The β-Arrestin-Like Protein Rim8 Is Hyperphosphorylated and Complexes with Rim21 and Rim101 To Promote Adaptation to Neutral-Alkaline pH
... transcription factor in response to environmental pH (3, 13, 42, 48). Much like the  -arrestin proteins in mammalian systems, C. albicans Rim8 interacts with a receptor, Rim21, which senses en- vironmental pH. ...
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β arrestin control of late endosomal sorting facilitates decoy receptor function and chemokine gradient formation
... To observe the fate of internalized Cxcl12a with respect to its receptor, we transplanted cells expressing Cxcr7b-DsRed into embryos expressing Cxcl12a-EGFP. Interestingly, the EGFP signal was rapidly reduced following ...
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A Roadmap to Understanding Toll Pathway Changes: An Educational Primer for Use with “Regulation of Toll Signaling and Inflammation by β-Arrestin and the SUMO Protease Ulp1”
... The labels at the top right of the figure show what conditions or variables were included (+) or omitted (2) from each experimental sample. The labels to the right of each gel im- age list the antibody used to detect the ...
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Regulation of Toll Signaling and Inflammation by β-Arrestin and the SUMO Protease Ulp1
... In this study, we present evidence that reveals a novel function of the b-arrestin Krz in controlling sumoylation and preventing systemic inflammation in Drosophila larvae. Our results can be summarized in the ...
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β Cell–intrinsic β arrestin 1 signaling enhances sulfonylurea induced insulin secretion
... pancreatic β cells showed pronounced metabolic ...regulating β cell function and whole-body glucose ...in β cells of adult mice (β-barr1-KO mice). β-barr1-KO mice did not display any ...
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JC Polyomavirus Entry by Clathrin-Mediated Endocytosis Is Driven by β-Arrestin
... FIG 5 Reduction of clathrin heavy chain or  -arrestin prevents JCPyV entry. (A and B) SVG-A cells were transfected with EGFR control siRNA or siRNA targeting CHC (A) or  -arrestin (  -arr) (B). Cells ...
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Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling.
... The complement cascade is comprised of a highly sophisticated network of innate immune proteins that are activated in response to invading pathogens or tissue injury. The complement activation peptide, C5a, binds two ...
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