β-carboline
QSAR Analysis on β-carboline as Antitumor Agent
... on β-Carboline derivatives as an anti-tumor agent was performed with 30 compounds of β-Carboline derivatives on different cancer cell lines from reported ...of β-carboline ...
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Synthesis of novel β-carboline derivatives with potential antimicrobial and anti helminthic activities
... Some β- carboline derivatives bearing guanidinium group or amino group-terminated side chain, were known to exhibit inhibitory activities on Tat-TAR interaction as well as to HIV-1 in MT4 ...A β- ...
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Computational Chemistry Application of Physicochemical Descriptors: QSAR Study on Some β Carboline Compounds
... An attempt has been made to perform the quantitative structure-activity relationship studies of these derivatives utilizing theoretical molecular descriptors calculated computationally from the structure of these ...
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The antiviral (RNA & DNA) profile of some incomplet e C nucleosides inspired from natural β carboline (pyrido [3,4 b] indole) scaffold; pharmacology of the intermediates in the total synt hesis
... Standard cell-culture techniques were adopted by the research institute of TOSOH CO-LTD, Japan, to determine the 50% effective concentrations of the tested β–carboline derivatives (µM/ml) that arrest viral ...
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cis (9S,10S) Methyl 1 propyl 1,2,3,4 tetrahydro β carboline 3 carboxylate
... Keeping in mind the diverse biological activities of alkaloids containing an indole or indoline nucleus (Agurell et al., 1969; Bein, 1953; Johnson et al., 1963; Herraiz, 2000), we have designed and synthesized some ...
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Oxidative Cyclizations of Tertiary Pentenols and the Synthesis of β-Carboline Alkaloids
... Following the procedure of Liang, an attempt was made to methylate the nitrogen of the β-carboline with methyl iodide followed by deprotonation to form chrysotricine. Analysis of the crude material after ...
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Chemical screening identifies the β-Carboline alkaloid harmine to be synergistically lethal with doxorubicin.
... Such serious side effects warrant the hunt for novel interven- tions that can help prevent anthracycline-induced cardiotoxicity. Anticancer drug research in the last 20 years has utilized novel strategies to identify ...
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In vitro evaluation of β carboline alkaloids as potential anti Toxoplasma agents
... Background: Toxoplasmosis is a worldwide infection caused by the protozoan parasite Toxoplasma gondii, which causes chorioretinitis and neurological defects in congenitally infected newborns or immunodeficient patients. ...
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Therapeutic journey of synthetic betacarboline derivatives: A short review
... Quantitative structure–activity relationship (QSAR) studies have been performed on β- carboline derivatives to explore the structural necessities for antitumor activity. 3D QSAR studies were done using ...
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Dual targeting of microtubule and topoisomerase II by α-carboline derivative YCH337 for tumor proliferation and growth inhibition
... the β-carboline moiety of β-carbolines derived from the marine alkaloid manzamine A or arborescidine alkaloids, which is responsible for their Top2 inhibition [9, 43, ...
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ZINC44018332, ZINC2101723, ZINC2094526, ZINC2094304, ZINC2104482, ZINC3984030,
... as β-carboline ...(2018), β-carboline Alkaloids are widely distributed in nature, and its derivatives exhibited activity against Herpes Simplex Viruses by blocking virus ...two ...
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Synthesis and biological evaluation of -carboline derivatives as an anxiolytic agents
... Compound 4a showed maximum activity as compared to other compounds. The maximum activity shown by 4a may be due to hydroxyaniline at C-3 position of β-carboline ester. Synthesized compound 4a and standard ...
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PHARMACOLOGICAL PROPERTIES OF EURYCOMA LONGIFOLIA–A REVIEW
... 1) Ang HH, Hitotsuyanagi Y, Fukaya H, Takeya K. Quassinoids from Eurycoma longifolia. Cytotoxic and antimalarial β-carboline alkaloids from the roots of Eurycoma longifolia. Effects o[r] ...
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Preparation of 1-Substituted Tetrahydro-beta-carbolines by Lithiation-Substitution
... tetrahydro- β -carboline 2e to a solution of premixed n-BuLi and chiral ligand (+)-sparteine-surrogate at − 78 ° C, which can be used in THF, 15 followed by trapping after only 5 min with the electrophile ...
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γ-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3- and 5- component cascades
... A series of allylic -carbolines have been synthesised via efficient 3- and 5- component palladium catalysed cascade reactions leading to the creation of a range of substituted carboline-based compounds, some of ...
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Dysregulation of the (immuno)proteasome pathway in malformations of cortical development
... The proteasome is an evolutionarily conserved multica- talytic proteinase complex representing a major protein degradation system, present in the nucleus and cytoplasm of eukaryotic cells, that regulates diverse ...
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β Alanine β alaninium picrate
... The H atom dissociated from the picric acid as a proton is disordered and is bonded to the carboxyl group of both the alanine molecules 50% each, as required by the centrosymmetric arran[r] ...
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Immune effects of Alarelin on ovarian development and GnRH receptor mRNA expression levels of pituitary in tilapia (Oreochromis niloticus)
... The GnRH-a antigen showed good antigenicity and immunogenicity in female tilapia in that it induced anti-GnRH antibodies when combined with an intrinsic macromolecular immunogenic protein (Hosseini, Aleyasin, Saeedi, ...
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Haplotype Analysis of β-Thalassaemia Major and Carriers with Filipino β-Deletion in Sabah, Malaysia
... Filipino β°-deletion is an extensive ...Filipino β°-deletion might be the consequence of genetic events occurring between the 5’ and 3’β-globin gene region during a recombination ...
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Synthesis of Capsaicin Oligosaccharides and Their Anti Allergic Activity——Synthesis of Capsaicin Oligosaccharides as Anti Allergic Food Additives
... capsaicin β-me- libioside 5 (total yield, ...saicin β-melibioside is shown in Figure 2. Capsaicin β- isomaltoside 6 was prepared by the similar procedure (total yield, ...
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