β-lactam resistance
Clinical and Microbiological Aspects of β Lactam Resistance in Staphylococcus lugdunensis
... Previous studies indicate that S. lugdunensis is relatively uncommon in clinical specimens but is unique from the perspectives of virulence and antimicrobial suscep- tibility (2, 21). The present retrospective analysis ...
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Predictability of Phenotype in Relation to Common β Lactam Resistance Mechanisms in Escherichia coli and Klebsiella pneumoniae
... OmpK36 defects are associated with resistance to ETP and CAZ in K. pneumoniae. The major nonspecific porins expressed in E. coli are the OmpF matrix porin and the OmpC osmoporin, with their equivalents being ...
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Inducible β Lactam Resistance in Aeromonas hydrophila: Therapeutic Challenge for Antimicrobial Therapy
... of resistance to broad-spec- trum antibiotics, and the identical genetic clonality demon- strated by AP-PCR and PFGE, A139 was an in vivo resistant mutant of the wild-type ...their resistance to cefotaxime, ...
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Evaluation and Updating of the Osiris Expert System for Identification of Escherichia coli β Lactam Resistance Phenotypes
... Osiris is a video zone size reader for disk diffusion tests that includes a built-in extended expert system (EES). We evaluated the efficacy of the Osiris EES for the identification of  -lactam susceptibility ...
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Regulation of AmpC-Driven β-Lactam Resistance in Pseudomonas aeruginosa: Different Pathways, Different Signaling
... expression to basal levels. This is the reason why UDP- NAM-P5 has been known as an AmpC repressor (13, 16, 17). Conversely, when bacteria are exposed to the so-called inducer  -lactams (e.g., cefoxitin), the derived ...
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Appearance of β-lactam resistance genes in agricultural soils and clinical isolates over the 20th century
... Therefore, if manure-borne bla genes in archived soils and parallel clinical resistance are roughly synchronous, the question is which came first: environmental or clinical bla AR. Based on our data, one cannot ...
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Phenotypic and genetic characterization of β-lactam resistance in Klebsiella from retail chicken meat in Mansoura, Egypt
... Many recent reports showed that retail chicken meat has been indicated as a potential source of bacteria containing β-lactamase encoding genes (9, 36, 38-40). Since most ESBL genes are plasmid-encoded, there is a ...
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Penicillin Binding Protein Transpeptidase Signatures for Tracking and Predicting β Lactam Resistance Levels in Streptococcus pneumoniae
... -lactam resistance through altering their penicillin-binding proteins (PBPs) and have become a major concern in choosing effective patient ...-lactam resistance, we obtained the sequence ...
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ANTIBACTERIAL ACTIVITY OF NEW β-LACTAM COMPOUND
... of β-lactamases is the most frequent factor contributing to β-lactam resistance ...of β -lactamase is based on the amino acid sequence and divides β-lactamases into class A, C ...
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Surface-bound antibiotic for the detection of beta-lactamases
... susceptibility. β-Lactam-based antimicrobials are one of the most commonly used classes of ...(the β-lactam), rendering the drug inactive. Resistance to these classes of antibiotics is ...
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Analysis of Potential β Lactam Surrogates To Predict In Vitro Susceptibility and Resistance to Ceftaroline for Clinical Isolates of Enterobacteriaceae
... One strategy to address the lack of immediate access to in vitro testing for a newer agent is to test a readily available surrogate agent (usually in the same class) to predict susceptibility or resistance to the ...
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Complete genome sequence of Pseudomonas citronellolis P3B5, a candidate for microbial phyllo-remediation of hydrocarbon-contaminated sites
... exhibited resistance to several ...antibiotic resistance genes on raw consumed herbs we therefore investigated if those resistances are encoded on mobile genetic ...
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Clinical Isolates of Staphylococcus aureus Show Variation in β Lactamase Production and Are More Susceptible to Antibiotics Conjugated with β Lactamase Inhibitors
... to β -Lactam antibiotics by bacteria involve the production of inactivating enzymes— β -Lactamases—which is capable of hydrolyzing the β -Lactam ring leading to loss of ...different ...
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<p>Investigation of Antibiotic Resistance, Serotype Distribution, and Genetic Characteristics of 164 Invasive <em>Streptococcus pneumoniae</em> from North China Between April 2016 and October 2017</p>
... in China was clonal propagation. The prevalent clones serotype 14-ST876, serotype 19F-ST271, and serotype 19A-ST320 were responsible for the high resistance in invasive strains. The proportion of S. pneumoniae ...
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Non–β-Lactam Antibiotic Hypersensitivity Reactions
... least 1 antimicrobial medication in 2015. 7 b-lactam antibiotics were the most frequently dispensed antibiotics across all ages; however, NBLAs accounted for a significant proportion, with macrolides accounting for ...
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In Vitro Comparative Efficacy of Carbapenems and β-Lactam β-Lactamase Inhibitor Combinations Against Multi Drug Resistant Gram Negative Bacilli
... The resistance to imipenem is present in bacteria that produce β -lactamases with specific carbapenemase activity which is found only in a very small population of organisms suggesting that the spread of ...
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New treatment options against gram negative organisms
... the β-lactam ring) imparts potent activity against class A and C β- lactamases, such as the AmpC enzyme, which is not observed with the currently used ...A β-lactamases) and AmpC enzyme with ...
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High levels multi-resistance to antibiotics among extended-spectrum β-lactamases-producing Enterobacteriaceae from Northwest Morocco
... In Morocco, dissemination of ESBL Enterobacteriaceae is worrying. The detection of ESBL producers in laboratories is required for the dissemination control of these organisms. Therefore, there is an urgent need of ...
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Examining the validity and reliability of the Activities Specific Balance Confidence Scale 6 (ABC 6) in a diverse group of older adults
... to β-lactam antibiotics. In theory, Spm/β-lactam synergy can be achieved through two possible mechanisms: 1) Spm may have the same primary target as β -lactams by attacking the cell ...
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Antimicrobial susceptibilities of Proteus mirabilis: a longitudinal nationwide study from the Taiwan surveillance of antimicrobial resistance (TSAR) program
... AmpC β-lactamase-producers increased signifi- cantly over the study ...AmpC β-lactamases genes were CMY-types ...AmpC β-lactamases to be prevalent, including Escherichia coli, Klebsiella pneumoniae, ...
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