β-Lactamase inhibitors
Effect of β-Lactamase inhibitors on in vitro activity of β-Lactam antibiotics against Burkholderia cepacia complex species
... of β-lactams has become compromised through the increasing presence of both chromosomally and plasmid-encoded β-lactamase ...against β-lactam antibiotics) [15]. In the Ambler scheme, four ...
8
Structural/mechanistic insights into the efficacy of nonclassical β‐lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates
... © 2017 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Calvopina, K, Hinchliffe, P, Brem, J et al. (8 more authors) (2017) Structural/mechanistic insights into the efficacy of ...
47
STABILITY AND ANALYSIS OF MEROPENEM AND β LACTAMASE INHIBITORS IN INJECTABLE PREPARATIONS
... The suitable chromatographic (RP-HPLC) method has been developed and validated for the estimation of fixed dose combinations of Meropenem with β-lactamase inhibitors in bulk and in injectable ...
20
Clinical Isolates of Staphylococcus aureus Show Variation in β Lactamase Production and Are More Susceptible to Antibiotics Conjugated with β Lactamase Inhibitors
... for β -Lactamase expres- sion by using two Penicillin G concentrations (5000 IU/ml and 25,000 IU/ml) in acidometric agar technique with phenol red as indicator, and the susceptibility pat- tern of the ...
7
In silico fragment based design identifies subfamily B1 metallo-β-lactamase inhibitors
... potent inhibitors were then screened in antimicrobial assays, studying the effect of co- administration on the minimal inhibitory concentration (MIC) of the clinically important carbapenem meropenem in MBL ...
19
BIOLOGICAL EVALUATION OF AROMATIC COMPOUNDS AS β-LACTAMASE INHIBITORS
... to β-lactamase enzyme is frequent in Colombia and it has important consequences in term of morbidity and ...the β-lactamase enzyme of 5 compounds gave as a result more powerful compounds than ...
6
Thiol-Containing Metallo-β-Lactamase Inhibitors Resensitize Resistant Gram-Negative Bacteria to Meropenem
... MBL inhibitors than compounds 1 and 2 in biochemical enzyme inhibition assays, 17,18,21,23 and our MIC synergy results follow the same ...of inhibitors 1 − ...
7
Structural/mechanistic insights into the efficacy of non-classical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates
... systems (Alonso & Martinez, 2000, Gould & Avison, 2006, Garcia-Leon et al., 2015, Gould et al., 2013) that reduce the net rate of entry for many antimicrobials, -lactam resistance arises primarily from production ...
43
A multicentre clinical study on the injection of ceftriaxone/sulbactam compared with cefoperazone/sulbactam in the treatment of respiratory and urinary tract infections
... China has one of the world’s highest reported rates of bac- terial resistance. For cephalosporins, the most frequently used antimicrobials clinically, the emergence and preva- lence of bacterial resistance, especially to ...
8
MOLECULAR CHARACTERIZATION OF PSEUDOMONAS AERUGINOSA ISOLATES RECOVERED FROM HUMAN PATIENTS IN HIMACHAL PRADESH (INDIA) FOR SELECTIVE GENES: EXTENDED SPECTRUM β LACTAMASE (ESBL), AMPICILLIN CLASS C (AMPC) AND METALLO β LACTAMASE (MBL) GENES
... β-lactamase inhibitors such as clavulanic acid, tazobactam, sulbactam inhibit ...AmpC-type β- lactamases may be carried on chromosome or plasmids of bacterial ...
12
Antimicrobial susceptibilities of Proteus mirabilis: a longitudinal nationwide study from the Taiwan surveillance of antimicrobial resistance (TSAR) program
... and β-lactam/β-lactamase ...to β-lactams mediated by acquired β-lactamases emerged in 1990s ...these β-lactamases, plasmid-borne extended-spectrum β-lactamases (ESBL) and ...
10
In Vitro Comparative Efficacy of Carbapenems and β-Lactam β-Lactamase Inhibitor Combinations Against Multi Drug Resistant Gram Negative Bacilli
... -lactamase inhibitors include clavulanic acid, sulbactam and ...of β -lactamases against more ac- tive β -lactam compounds such as penicillins and ...
6
CHEMISTRY OF β-LACTAM SULTAMICILLIN AS A MUTUAL PRODRUG OF AMPICILLIN AND SULBACTAM WORKS AS AN AZABICYCLO [3.2.0] HEPTANE CARBOPENAM BIOPRECURSOR
... a β- lactam antibiotic and a β-lactamase ...produce β- lactamase enzymes that can inactivate ampicillin through ...the β-lactamase ...other β-lactamase ...
8
Characterization of a fusion protein of RGD4C and the ß-lactamase variant for antibody-directed enzyme prodrug therapy
... RGD4C- β L was added at a final concentration of 2 µΜ , and following incubation for 60 minutes on ice, the cells were washed with fresh medium three ...RGD4C- β L, melphalan, and C-Mel, at several ...
7
Risk factors and outcomes in non-transplant patients with extended-spectrum beta-lactamase-producing Escherichia coli bacteremia: a retrospective study from 2013 to 2016
... tended-spectrum β-lactamase (ESBL)-producing bacteria ...of β-lactamase en- zymes is the principal mechanism by which Gram-negative bacteria resist the action of β-lactam ...
11
Frequency of AmpC β-lactamase Resistance in Escherichia coli Isolates from Urinary Tract Infections in Gorgan, Iran
... [1]. β-lactam antibiotics are commonly used in the treatment of hospital-acquired ...of β-lactams by β- lactamases is the most common mechanism of resistance in Gram-negative ...of ...
8
Critical evaluation of ceftolozane–tazobactam for complicated urinary tract and intra-abdominal infections
... approved β -lactam/ β -lactamase inhibitor for the treatment of cUTIs, and cIAIs in combination with ...AmpC β -lactamases, as well as efflux pumps and porin deficiencies; therefore, it has ...
11
Complete genome sequence of Pseudomonas citronellolis P3B5, a candidate for microbial phyllo-remediation of hydrocarbon-contaminated sites
... To isolate bacteria from the basil phyllosphere, 30 g of plant material were suspended in 100 ml peptone water (9 g/L NaCl, 1 g/L tryptone (Merck, Germany)), proc- essed for 3 min in a stomacher (Smasher, AES Chemu- nex, ...
12
Detection of Metallo β lactamase in gram negative bacilli
... But certain organisms have evolved in such a way that the effect of these carbapenems no longer seem to be very promising. Two types of carbapenem hydrolyzing enzymes have been described –the serine enzymes which have a ...
5
Cyclic Boronates Inhibit All Classes of β-Lactamase
... Cloning. Serine  -lactamases were amplified by direct PCR from producer bacterial strains and expressed as N-terminal hexahistidine fusions from the T7 vector pOPINF (53). CTX-M-15 was amplified from E. coli strain EO516 ...
13