β-Secretase (BACE)
Decreasing the expression of PICALM reduces endocytosis and the activity of β secretase: Implications for Alzheimer's disease
... by β-secretase after deple- tion of PICALM probably due to less APP being endo- cytosed into early endosomes to encounter ...of BACE mRNA by about 20 % and PICALM depletion reduced protein levels by ...
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The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease
... the β-secretase has been intensely sought because of its prime status as a drug target for ...of β-secretase activity in cells and tissues had been extensively ...the β-secretase ...
6
The Alzheimer's disease β-secretase enzyme, BACE1
... The BACE1 propeptide domain is removed within the Golgi apparatus by cleavage between Arg45 and Glu46 [47,74]. Unlike the majority of aspartic proteases, includ- ing BACE2, which cleave the propeptide domain autocat- ...
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Shrimp (Pandalopsis dispar) waste hydrolysate as a source of novel β–secretase inhibitors
... for β–secretase inhibition. In the β–secretase inhibitory mechanism, leucine plays an im- portant role in the Swedish mutant APP, which has a mu- tation at the P2–P1 positions from Lys–Met to ...
7
Purification and characterization of β-secretase inhibitory peptide from sea hare (Aplysia kurodai) by enzymatic hydrolysis
... of β -amyloid peptides (A β ), is observed in brains of the patients with Alzheimer ’ s disease (AD) and is one of the key factors in etiology of the ...for β -secretase inhibitory ...highest ...
8
BACE2, a conditional β-secretase, contributes to Alzheimer’s disease pathogenesis
... the β-secretase activity of ...the β-secretase activity of ...BACE2-mediated β-cleavage of wild-type APP through binding to the ...As β-secretase activity, but not BACE1, ...
16
Westmeyer, Gil Gregor (2006): Identification of a BACE dimer and characterization of its biochemical and enzymatic properties. Dissertation, LMU München: Medizinische Fakultät
... of BACE at 60 kDa, the authors term this BACE species a dimer, although they do not strictly show, that this is the ...The BACE “dimer”, was not detected by a pro-domain specific antibody suggesting ...
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A novel BACE inhibitor isolated from Eisenia bicyclis exhibits neuroprotective activity against β-amyloid toxicity
... of β-secretase inhibition, kinetic analysis was performed using different substrate (500, 750, 1000, and 1500 nM) and inhibitor ...a β-secretase ...against β-secretase: ...
9
Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site
... meprin β and APP bearing the Swedish double mutation K670N/ M671L (APPswe) which is located in close vicinity of the β-secretase cleavage ...meprin β mediated Aβ2-40/42 generation. Al- though ...
16
Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer’s disease mouse model
... α-, β- and γ-secretase, which ultimately re- sult in the formation of Aβ ...APP, BACE-1 (β-secretase) and ADAM-10 (α-secretase) protein levels were unaltered by the drug, ...
10
Spotlight on BACE: The secretases as targets for treatment in Alzheimer disease
... 1999, β-secretase (BACE, Asp2, Memapsin) was definitively identified as a novel membrane-bound aspartic proteinase, providing the essential tool in the search for specific inhibitors of β ...
5
The effect of traumatic brain injury in experimental models of Alzheimer’s disease
... Beta-amyloid Aβ Amyloid intracellular domain AICD Alzheimer’s disease AD Apolipoprotein E APOE Amyloid precursor protein APP Aquaporin 4 AQP4 Β-secretase BACE Bone marrow derived macroph[r] ...
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Stepping closer to treating Alzheimer’s disease patients with BACE1 inhibitor drugs
... of β -amyloid peptide (A β ) is widely believed to induce pathological changes and cause dementia in brains of AD ...the β -secretase site. Only after this cleavage does γ -secretase ...
11
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
... A β : Amyloid β ; BACE1: β -secretase; CHO: Chinese hamster ovary cell line; CHX: Cycloheximide – inhibitor of protein biosynthesis; CT: C- terminus; CTF: C-terminal fragment; DAPT: ...
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β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage
... Alzheimer’s disease (AD) is a slowly progressing brain dis- ease manifesting several neuropathological characteristics including accumulation of extracellular plaques, mainly composed of amyloid-β (Aβ) peptides of ...
8
MH84 improves mitochondrial dysfunction in a mouse model of early Alzheimer’s disease
... initial β-secretase cleavage resulting in peptide ...[9]. β-Secretase, γ- secretase, and Aβ itself were identified as pharmacological targets ...
12
Heteromers of amyloid precursor protein in cerebrospinal fluid
... sAPP β was resolved with the IBL- β ...sAPP β was resolved with IBL- β ...sAPP β was resolved with the IBL- β ...IBL- β and IBL- α ...the β -secretase and α ...
11
Insights into the roles of lncRNAs in skeletal and dental diseases
... BACE1: β-secretase-1; BMSC: bone marrow stem cell; BMP-2: bone morphogenetic protein 2; CDCP1: CUB-domain-containing protein 1; ceRNA: competing endogenous RNA; DANCR: differentiation-antagonizing long ...
10
Dysregulation of protein trafficking in neurodegeneration
... of β -amyloid (A β ) peptide ...A β in the brain is a primary cause of AD and attenuation of A β generation has become a topic of extreme interest in AD ...A β is generated from ...
9
Büll, Dominik (2010): Die Repression der Translation der anti-amyloidogenen Sekretase ADAM10 durch die 5’-untranslatierte Region. Dissertation, LMU München: Medizinische Fakultät
... Zur Analyse der mRNA Expression von humanem ADAM10 wurden kommerziell erworbene MTN-Blots über Nacht mit einer radioaktiv gelabelten cDNA-Sonde hybridisiert. (A) Die Sonde umfasste die Nukleotide 1-432 der 5'UTR von ...
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