β-Thalassemia
Hepcidin and HFE Polymorphisms and Ferritin Level in β-Thalassemia Major
... β-Thalassemia is the most common inherited anemic disorder in Iran; this disorder is caused by mutations in β globin ...gene. β-Thalassemia- associated anemia occurs due to decreased ...
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Effect of Pamidronate on Osteoporosis in Patients with β-Thalassemia Major
... Patients and Methods: This cross sectional study was conducted on 20 patients with β-thalassemia major with osteoporosis. Patients received Pamidronate injections (30 mg in equal intervals of one month) for ...
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Reducing TMPRSS6 ameliorates hemochromatosis and β thalassemia in mice
... include β-thalassemia intermedia, Hb E β-thalassemia, and Hb H disease ...of thalassemia each year ...from β-thalassemia ...
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Complications of Transfusion-Dependent β-Thalassemia Patients in Sistan and Baluchistan, South-East of Iran
... Sistan and Baluchistan province, which is located in a sub-tropical area in the South-East of Iran, harbors as high as 10 % of β-thalassemia carrier population (in comparison with 4-8% of the carriers in ...
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Serum lipid profile and ferritin in β Thalassemia trait patients
... In β-thalassemia major, liver damage accounts for the low total-cholesterol density lipoprotein cholesterol (HDL-C) and low cholesterol (LDL-C) serum levels ...in thalassemia minor subjects were ...
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Novel Meta-Heuristic Model for Discrimination between Iron Deficiency Anemia and Β-Thalassemia with CBC Indices Based on Dynamic Harmony Search (DHS)
... or β-thalassemia, regardless of whether the subject has the disease or the trait, hemoglobin concentration becomes lower than ...or β- globin (β-thalassemia) ...or β-globin ...
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Spectrum of β-thalassemia Mutations in Iran, an Update
... common thalassemia severe phenotype among ...of β –TM has provided a great opportunity regarding diagnostic ...for β –TM and effective prenatal diagnosis (PND) molecular screening ...of β –TM, ...
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Molecular Study on β-Thalassemia Patients in Iraq
... of β-thalassemia, identified by the Sulaimaniyah Provincial Premarital Screening Program in northeastern Iraq, a total of eight different β- thalassemia mutations were identified in the ...
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The pregnancy outcome in patients with minor β-thalassemia
... Background: β-thalassemia is the most common hereditary disease in Iran and more than 2 million carriers of the β-thalassemia mutant gene are living in this ...with β-thalassemia ...
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Preliminary Report on the Frequency of Pro12Ala Polymorphism of the Peroxisome Proliferator-Activated Receptor-gamma Gene in Egyptian β-Thalassemia Major Patients
... Osteoporosis represents an important cause of morbidity in adult thalassemic patients. Peroxisome proliferator-activated receptor-γ (PPAR γ) is a master transcriptional regulator involved in expression of probably ...
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Original Article Genetic diagnosis of β-thalassemia preimplantation using short tandem repeats in human cryopreserved blastocysts
... two β-thalassemia carriers under- went in vitro fertilization (IVF) procedures and ...for β-thalassemia, and 18 blastocysts were homozygous or compound ...for β-thalassemia, ...
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Early Detection of Renal Dysfunction in β Thalassemia with Focus on Novel Biomarkers
... in β thalassemia patients compared with ...in thalassemia patients compared to healthy control group ...with β TM found increased urinary excretion of β2-M in ...
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Understanding globin regulation in β thalassemia: it’s as simple as α, β, γ, δ
... Homozygous β-thalassemia (also known as Cooley anemia) has long been a model for the study of diseases caused by mutations and deletions at a single genetic locus, in this case, the β-globin ...
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Treatment Status of Patients with Β-Thalassemia Major in Northern Iran: Thalassemia Registry System
... er parts of Iran (9). The prevalence of β- thalassemia is reported to be 10% in these areas (9). At least 1385 patients with β thalassemia ma- jor live in Mazandaran Province. There may still ...
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Molecular characterization of β-thalassemia intermedia in the West Bank, Palestine
... eight thalassemia centers in the major hospi- tals administered by the Palestinian Ministry of Health (MOH) in the West Bank were ...all thalassemia patients and identified 70 potential TI pa- tients from ...
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A validated cellular biobank for β thalassemia
... protocols [4]. This is particularly important to test a vari- ety of treatments on primary cells isolated from affected patients in order to develop novel diagnostic, prognostic and therapeutic approaches, toward ...
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Prevalence of Diabetes Mellitus in Patients with Transfusion Dependent β Thalassemia
... 437 β‐ thalassemic patients, 58 patients had the thalassemia intermedia and 379 patients had the thalassemia ...the thalassemia intermedia, ...the thalassemia major, ...
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Translation of β Globin m RNA in β Thalassemia and the S and C Hemoglobinopathies
... hemoglobinopathies, hemoglobin S and hemoglobin C, the mutant b-chain is produced in smaller amounts than normal b A . Defective m-RNA translation has been suggested as a possible cause of decreased b-globin polypeptide ...
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Hemoglobin synthesis in β thalassemia: the properties of the free α chains
... The decrease in hemoglobin A (HbA, a 2 b 2 ) synthesis in the erythroid cells of patients with b-thalassemia is due to a selective defect in b-chain synthesis. Since a-chains continue to be formed at a normal rate ...
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Potassium permeability in β thalassemia minor red blood cells
... acquired increase in selective permeability of the membrane to K + . This phenomenon follows the depletion of energy sources in the thalassemia minor cells but does not follow comparable depletion in normal cells. ...
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