β-thalassemia major
Biochemical indices and radiological examination to evaluate bone health in children with β-thalassemia major
... all β- thalassemia major children included in the study, and also of 20 age and sex matched healthy children as controls were collected in plain bottles, centrifuged and serum was ...
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Effect of Pamidronate on Osteoporosis in Patients with β-Thalassemia Major
... Background: β-thalassemia major is a hereditary life threatening anemia which requires regular blood ...in thalassemia major is manifested by diffuse bone pain or deformity, spontaneous ...
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Clinical manifestations of β-Thalassemia major in two different altitudes; Bushehr and Shahrekord
... with β-thalassemia major (TM) develop iron overload through increased iron absorption and transfusional therapy and it’s the most important complication of ...TM. Thalassemia is common in ...
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Amantadine Plus Interferon-α Versus Interferon-α Monotherapy for the Treatment of Chronic Hepatitis-C Infection in β-Thalassemia Major Patients: A Randomized Double Blinded Pilot Study in Shiraz, Iran
... In this study, we compared the combination of INF-α plus amantadine versus INF-α alone in the treatment of HCV infected β-thalassemia major patients. The results revealed that although the ...
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Lipid profile in children of β-thalassemia major and their correlation with serum ferritin
... In the present study, we investigated the lipid pattern in blood of children with β Thalassemia major. It was observed that cholesterol, HDL cholesterol, LDL cholesterol levels were low and ...
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Prevalence of malocclusion and assessment of treatment needs in β-thalassemia major children
... or β -thalassemia major. The term “ thalassemia ” refers to a group of blood disorders characterized by decreased synthesis of one of the two types of polypeptide chain ( α or β ) which ...
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Renal Hemosiderosis among Iranian Transfusion Dependent β-Thalassemia Major Patients
... Subjects and Methods: Two-hundred and two patients with transfusion-dependent β-thalassemia major were included in this study in Zafar Adult Thalassemia Center, Tehran, Iran. For all patients, ...
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Hepcidin and HFE Polymorphisms and Ferritin Level in β-Thalassemia Major
... Results: There was no significant correlation between blood ferritin level and c.-582 A>G polymorphisms of hepcidin gene (p=0.58), and H63D of HFE gene (p=0.818). In addition, there was no significant association ...
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Preliminary Report on the Frequency of Pro12Ala Polymorphism of the Peroxisome Proliferator-Activated Receptor-gamma Gene in Egyptian β-Thalassemia Major Patients
... Osteoporosis represents an important cause of morbidity in adult thalassemic patients. Peroxisome proliferator-activated receptor-γ (PPAR γ) is a master transcriptional regulator involved in expression of probably ...
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Therapeutic Drug Monitoring of Chelating Agent Deferoxamine for β Thalassemia Major Patients
... This study, showed the importance of Therapeutic drug monitoring of DFO in β-thalassemia major patients. The adequacy of dose was not related to the poor drug re- sponse in the enrolled patients. ...
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Demographic and Laboratory Characteristics of β-Thalassemia Major Patients in Zahedan, Southeast of Iran
... of thalassemia patients is complex and ...for thalassemia has been in practice since 1997, its effectiveness in Sistan and Balouchistan province has been under question since families’ compliances have been ...
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Impacts of transfusion in β-thalassemia major patients receiving multiple blood transfusions
... at Thalassemia ward of ...145 thalassemia patients more than 3 years of age both males and females who were on transfusion therapy attending outdoor or being admitted in ...
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Analysis of Survival in Patients with β-thalassemia Major in Guilan, Northern Iran
... regular transfusion generally die earlier than age of 20-30 years. Patients receiving regular transfusion and proper iron-chelation usually survive beyond the fourth decade of life. Currently, cardiac complications such ...
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Bone Mineral Density in β Thalassemia Major and Intermedia, Correlation with Biochemical and Hormonal Profiles
... in thalassemia is manifested by diffuse bone pain, scoliosis, spinal deformities, nerve compression, spontaneous fractures, and severe ...with thalassemia major (TM) are presented with severe bone ...
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Treatment Status of Patients with Β-Thalassemia Major in Northern Iran: Thalassemia Registry System
... The most important indicator and treatment achievement is the increase in the patients' life span. Survival studies in Iran and other countries show the effect of proper treatment in patients' life span (13-15). ...
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Study of Growth Hormone Levels in Thalessemia Major Patients in Children
... A prospective study was conducted in the department of pediatrics, St George hospital Mumbai. The study was conducted on diagnosed patients of thalassemia major admitted to the pediatric wards. Duration of ...
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Zinc Status and its Correlation with Basic Parameters in Transfusion Dependent Thalassemic Patients: A Pakistani Perspective
... patients with established β-thalassemia major were enrolled in this study. Thirty patients were in regular follow up prior to study; others were registered during the study period. Ethical ...
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Factors associated with continuing emergence of β-thalassemia major despite prenatal testing: a cross-sectional survey
... This study included 32 mothers who had undergone prenatal testing. The mothers were registered at the TPFS and the MOH. A convenience sample was obtained from the archives of TPFS during a 3-month period, ranging from ...
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Relationship of Thyroid Hormone Status with Iron Overload in the Βeta-Thalassemic Tribal Children Receiving Multiple Blood Transfusions- A Cross-Sectional Descriptive Study
... a major public health problem in India, especially in tribal populations, is an autosomal recessive inherited blood disorder in which blood transfusion is the mainstay of treatment which in turn may lead to iron- ...
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Immigration and changes in the epidemiology of hemoglobin disorders in Italy : an emerging public health burden
... were β Thal carriers, 48 % suspected α Thal car- ...SCD, β thalassemia major and intermedia, α thalassemia (hemoglobin H), homozygous HbC, homozygous HbE and compound heterozygous ...
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