β-Tubulin
Deep amplicon sequencing of preselected isolates of Parascaris equorum in β tubulin codons associated with benzimidazole resistance in other nematodes
... Based on SNPs in codon 200 in other nematodes of veterinary interest, BZ resistance is likely to be a reces- sive trait [9]. Therefore in light of the results from the FECRT, there was little likelihood of finding high ...
8
Drosophila β Tubulin 97EF is upregulated at low temperature and stabilizes microtubules
... that β -Tubulin 97EF expression does not affect the microtubule growth rate, but results in microtubules that are less prone to destabilization by cold, colcemid and ...of β -Tubulin 97EF ...
15
Original Article Expression of β-tubulin in non-culprit arteries and effect of ramipril on lesion progression
... α/β tubulin, α-actinin, GTP enzyme activated protein with IQ motif, actin binding protein (ezrin protein, drebrin protein or cortactin ...α/β tubulin. Tubulin, one of the main ...
6
Class III β-Tubulin Counteracts the Ability of Paclitaxel to Inhibit Cell Migration
... of β 3-tubulin appeared to correlate with the insensitivity of cell migration to paclitaxel suppression, it did not establish a cause and effect ...of β 3 production (see Figure ...as β ...
10
Rationalization of paclitaxel insensitivity of yeast β tubulin and human βIII tubulin isotype using principal component analysis
... free state (pdb ID:1SA0), residues 278 to 285 in one of the loops is disordered in β-tubulin. Upon paclitaxel binding (pdb ID: 1JFF) this loop becomes ordered. Inter- actions between the two loops present ...
10
Phaeoacremonium parasiticum Infections Confirmed by β Tubulin Sequence Analysis of Case Isolates
... The sequences obtained were compared with the  -tubulin sequences avail- able from GenBank using a BLAST search. The sequences were consequently manually aligned in Sequence Alignment Editor, version 2.0a11 (23), ...
5
A Novel Step in β-Tubulin Folding Is Important for Heterodimer Formation in Saccharomyces cerevisiae
... only tubulin, but of course not actin, inter- to the chaperonin for another round of sequestered mediate filament subunits, or even the prokaryotic folding (Vainberg et ...
12
A β-Tubulin Mutation Selectively Uncouples Nuclear Division and Cytokinesis in Tetrahymena thermophila
... Despite the fundamental differences in micro- and macro- nuclear division (mitotic versus amitotic), expression of btu1-1 (K350M) impacts both processes. Since cytokinesis, cortical patterning, and oral apparatus ...
10
GENETIC ANALYSIS OF RESISTANCE TO BENZIMIDAZOLES IN PHYSARUM: DIFFERENTIAL EXPRESSION OF β-TUBULIN GENES
... This paper reports (1) isolation and genetic analysis of mutants of Physarum obtained by selecting for myxamoebal resistance to MBC, (2) analysis of the tubulins of MBC-[r] ...
19
ISOLATION AND CHARACTERIZATION OF MUTATIONS IN THE β-TUBULIN GENE OF SACCHAROMYCES CEREVISIAE
... When each of the resulting linear molecules is used to transform yeast carrying a tub2 mutation, selecting the plasmid URA3 marker, the region of the plasmid TUB[r] ...
20
GENETIC ANALYSIS OF B2t, THE STRUCTURAL GENE FOR A TESTIS-SPECIFIC β-TUBULIN SUBUNIT IN DROSOPHILA MELANOGASTER
... sional gels stained with silver (MERRIL et al. 1981); they display proteins present in mature motile sperm dissected from seminal vesicles of wild-type males (Figure 3a) [r] ...
12
SYNTHESIS, MOLECULAR DOCKING & EVALUATION OF ANTHELMINTIC ACTIVITY OF 2 (2 AMINO PHENYL) 1HBENZIMIDAZOLE DERIVATIVES
... with β tubulin at its active site its active site it interacts with Pi stacking and Hydrohen bonding Amino acids at active site Glycine 246B, Serine 178A, Tyrocine 224A, Valine 177A, Aspargine 249B ...
12
Genetic diversity in Dactylonectria pauciseptata associated with black foot disease in New Zealand
... Comparison of ITS, β-tubulin, EF1-α and histone genes among all 11 D. pauciseptata isolates showed that they were 99–100% identical to each other. These sequences were also compared with data present in the ...
9
Sperm inherited organelle clearance in C elegans relies on LC3 dependent autophagosome targeting to the pericentrosomal area
... To confirm that sperm-inherited mitochondria dynamics is dependent on microtubules, we depolymerized the microtubules using nocodazole, and tested the impact on the dynamics of the sperm-inherited mitochondria in the ...
12
Predicting Resistance by Mutagenesis: Lessons from 45 Years of MBC Resistance
... The first β-tubulin mutations reported in field isolates resulted in E198A, E198K, E198V, or F200Y amino acid substitutions (Koenraadt et al., 1992). These mutations have since been reported in a range of ...
9
miR-196a Enhances Neuronal Morphology through Suppressing RANBP10 to Provide Neuroprotection in Huntington's Disease
... Transfected cells were fixed, blocked and hybridized with primary antibodies, including P-GAP43 (Abcam; 1:500 dilution), RANBP10 (Proteintech; 1:500) and β -tubulin (Sigma; 1:1,000 dilution) antibodies. The ...
11
Isothermal diagnostic assays for the detection of soil transmitted helminths based on the SmartAmp2 method
... the β-tubulin ...(the β-tubulin sequence is known for all STH spe- cies and was suitable) rather than a multi copy sequence, such as a repeat region, which may show variability be- tween ...
12
Quick and Simple Detection Technique to Assess the Binding of Antimicrotubule Agents to the Colchicine-Binding Site
... of β-tubulin involved in the colchicine-binding site ...to β-tubulin forms an adduct that is easily detected by Western blot as a second immunoreacting band of β-tubulin that ...
5
A target based approach identifies genomic predictors of breast cancer patient response to chemotherapy
... of β-tubulin associated transcripts. β-tubulin is the mo- lecular target of taxane drugs, a commonly used class of chemotherapeutic drugs that includes docetaxel and paclitaxel (Taxotere W and ...
11
SYNTHESIS, MOLECULAR DOCKING & EVALUATION OF ANTHELMINTIC ACTIVITY OF 2 (2 AMINO ETHYL) 1HBENZIMIDAZOLE DERIVATIVES
... Synthesized compound A1-A7 also interacts with receptor β tubulin at its active site with Pi stacking and Hydrogen bonding interactions. Amino acids at active site Glycine 246B, Serine 178A, Tyrocine 224A, ...
11