β2 adrenergic receptor
Association of β2-adrenergic receptor gene polymorphisms (rs1042713, rs1042714, rs1042711) with asthma risk: a systematic review and updated meta-analysis
... Gly16 receptor could enhance agonist-promoted downregulation of receptor expression compared with the Arg16 ...Glu27 receptor is relatively resistant to agonist- promoted downregulation compared with ...
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Risk factors and myocardial infarction in patients with obstructive sleep apnea: impact of β2-adrenergic receptor polymorphisms
... The latter two polymorphisms and their haplotypes mod- ify the down-regulation of the β2-adrenergic receptor upon agonist stimulation. In a previous study [14], the Gly16/Gln27 haplotype underwent ...
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Preliminary study on association of β2 Adrenergic Receptor Polymorphism with hypertension in hypertensive subjects attending Balok Health Centre, Kuantan
... Polymorphisms within the β2-adrenergic receptor (ADRB2) gene have been repeatedly linked to hypertension. Among the ADRB2 polymorphisms detected, Arg16Gly and Gln27Glu codons are considered the two ...
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Original Article The genetic analysis of β2 adrenergic receptor gene polymorphisms and preterm birth risk in a Chinese population
... Abstract: Background: Preterm birth is a leading cause of perinatal morbidity and death with sequelae in adult. Genetic factors are proved to play an important role in the onset of preterm birth. In this study, the ...
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Etanercept restores normal insulin signal transduction in β2-adrenergic receptor knockout mice
... insulin receptor (tyrosine 1150/1151), in- sulin receptor (all purchased from Cell Signaling, Danvers, MA, USA), insulin receptor phosphorylated on Tyr960 (Cell Applications, San Diego, CA, USA), and ...
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Similarity and substructure based development of β2 adrenergic receptor ligands based on unusual scaffolds
... the receptor upon 26 binding of a signaling molecule to a cavity located at the 27 extracellular end between the seven ...-adrenergic receptor 31 ( β 2 AR) is considered a prototypical representative ...
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Similarity and substructure based development of β2 adrenergic receptor ligands based on unusual scaffolds
... fall below basal was due to inverse agonism, there should still be a cimaterol concentration response in the presence of 20µM 10, that was further right shifted, than that at 2 µM (Figure S1). As can be seen in Figure ...
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β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid derived suppressor cells
... that β2-AR activation in MDSCs increases the resistance of MDSCs to apoptosis induced by ...Fas receptor and the level of apoptosis were higher in MDSCs lacking ...in β2-AR–deficient MDSCs. Although ...
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Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling
... S1P receptor 3 [17-19]; 2) several studies, albeit in HEK 293 cells, have shown that angiotensin type 1A receptor-mediated regulation of RhoA activity is βarr-sensitive [37-39]; and 3) β2AR stimulation was ...
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Influence of β2 adrenergic receptor genotype on risk of nocturnal ventilation in patients with Duchenne muscular dystrophy
... the receptor, improv- ing its ...higher receptor density, and is more resistant to receptor down-regulation than its Arg16 counterpart [29, ...
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The Gln27Glu Polymorphism in β2-Adrenergic receptor gene is linked to hypertriglyceridemia, hyperinsulinemia and hyperleptinemia in Saudis
... b2-3 adrenergic receptors or adrenoceptors, regulate body fat accumulation and play a central role in the reg- ulation of energy expenditure ...the receptor, Gln27Glu ...
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Effect of β2 Adrenergic Receptor Polymorphism in Asthma Control of Patients Receiving Combination Treatment
... Purpose: Combination treatment of inhaled corticosteroid (ICS) plus long-acting β 2-agonist (LABA) is widely used as a maintenance regimen for the management of asthma. This study evaluated the effect of the β ...
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β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
... of receptor phosphorylation by G protein-coupled receptor kinases (GRKs) and recruitment of the multifunctional adapter protein, β-arrestin [13, ...initiate receptor desensitization, internalization, ...
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Association of β2 Adrenergic Receptor Polymorphism with Work Related Symptoms in Workers Exposed to Wheat Flour
... adrenergic receptors and wheat-specific antibodies in association with the clinical pa- rameters of baker’s asthma. Materials and Methods: In total, 379 subjects working in a single industrial bakery were enrolled ...
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GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility
... (D) Western blotting for GRK5 in total cardiac extracts from B1KO and β ARKct/B1KO (CT/KO) mice at 24 hrs and at 4 weeks (wks) post-MI. Representative blots of 4 independent experiments [r] ...
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Characterization of a panel of six β2-adrenergic receptor antibodies by indirect immunofluorescence microscopy
... We conducted semi-quantitative studies to define a linear range for detecting human β 2 AR using Ab-13989 on four HEK 293 cell lines stably expressing different levels of the β 2 AR ranging from 280,000 to 2,900,000 ...
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Prenatal exposure to β2-adrenergic receptor agonists and risk of autism spectrum disorders
... ASD case status was determined by diagnoses recorded in medical records. A subset of 50 cases was also evaluated with the Autism Diagnostic Interview- Revised (Lord et al. 1994) and the Autism Diagnostic Observation ...
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Enhancement of cardiac function after adenoviral mediated in vivo intracoronary β2 adrenergic receptor gene delivery
... Exogenous gene delivery to alter the function of the heart is a potential novel therapeutic strategy for treatment of cardiovascular diseases such as heart failure (HF). Before gene therapy approaches to alter cardiac ...
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Original Article Relationship between the β1-adrenergic receptor and the β2-adrenergic receptor in hypertension
... predominant receptor subtype in the heart, increases myocardial contractility and regulates cardiac excitation-contraction cou- ...Similarly, β2-AR also has a functional role in myocardial contraction ..., ...
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Inhibition of p38α MAPK rescues cardiomyopathy induced by overexpressed β2 adrenergic receptor, but not β1 adrenergic receptor
... We examined the role of p38a MAPK in mediating cardiomyopathy in mice overexpressing b 1 -adrenergic receptor (b 1 -AR) or b 2 -AR by mating them with dominant-negative p38a (DNp38a) MAPK mice. Both b 1 -AR ...
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