β2-adrenergic receptor polymorphism
Preliminary study on association of β2 Adrenergic Receptor Polymorphism with hypertension in hypertensive subjects attending Balok Health Centre, Kuantan
... The demographic and clinical data of the subjects in this study are as shown in Table II and III respectively. There was no statistical difference for both age and race between hypertensive and non hypertensive groups. ...
6
Association of β2 Adrenergic Receptor Polymorphism with Work Related Symptoms in Workers Exposed to Wheat Flour
... Genomic DNA was prepared from whole blood samples using a Puregene DNA purification kit (Gentra Systems, Minneapolis, MN, USA) according to the manufacturer’s protocol. Genotyping of each polymorphism was per- ...
7
Effect of β2 Adrenergic Receptor Polymorphism in Asthma Control of Patients Receiving Combination Treatment
... 2-adrenergic receptor ( ADRB2) polymorphism on lung function and asthma control with regular use of combination treatment of an inhaled ICS plus ...
7
Beta adrenergic receptor polymorphisms: A basis for pharmacogenetics
... The most common β2-adrenergic receptor polymorphism in Greeks is the nucleotide substitution guanine for adenine at position 46 46 G/A resulting in amino acid substitution glycine for ar[r] ...
6
Effect of β2-adrenergic receptor gene (ADRB2) 3′ untranslated region polymorphisms on inhaled corticosteroid/long-acting β2-adrenergic agonist response
... length polymorphism has been identified in a ‘C’ nucleo- tide-rich region 23 bp downstream from the translation stop codon of ADRB2 in the poly-C repeat region ...single-nucleotide polymorphism (SNP) ...
9
Possible association of β2 and β3 adrenergic receptor gene polymorphisms with susceptibility to breast cancer
... With regard to the Trp64 → Arg polymorphism in the ADRB3 gene, those who harboured at least one Arg allele had a crude OR of 0.85 (95% CI 0.55–1.31) relative to those who were homozygous for Trp. The OR for post- ...
6
Influence of β2 adrenergic receptor genotype on risk of nocturnal ventilation in patients with Duchenne muscular dystrophy
... Pilot studies have shown an improvement in isometric knee-extensor strength and manual muscle test scores in DMD patients following 12 weeks of ADRB2 agonist treatment [47]. A larger follow-up study also demon- strated ...
8
The effects of beta2 adrenergic receptor gene polymorphism in lipid profiles
... three β2-AR gene polymorphism genotypes are shown in Table ...the β2-AR gene polymorphism (P = ...the β2-AR gene polymorphism, Genotype Arg/Arg subjects had higher TC and LDL-C ...
7
Haplotype Analysis of the β2 Adrenergic Receptor Gene and Risk of Myocardial Infarction in Humans
... in receptor affinity, a markedly lotype for the regression ...Table receptor has been associated with increased downregu- ...T164I polymorphism with the outcome of patients with analyze the data in ...
6
The Gln27Glu Polymorphism in β2-Adrenergic receptor gene is linked to hypertriglyceridemia, hyperinsulinemia and hyperleptinemia in Saudis
... b2-3 adrenergic receptors or adrenoceptors, regulate body fat accumulation and play a central role in the reg- ulation of energy expenditure ...Gln27Glu polymorphism in the b 2AR gene has been considered ...
6
Original Article The genetic analysis of β2 adrenergic receptor gene polymorphisms and preterm birth risk in a Chinese population
... librium (LD) of two polymorphisms was analyzed with Haploview software. Odds ratio (OR) with 95% confidence interval (95% CI) was calculated to show the relative risk of preterm birth. Results: The heterozygous genotype ...
6
Effects of In Utero and Childhood Tobacco Smoke Exposure and β2-Adrenergic Receptor Genotype on Childhood Asthma and Wheezing
... Arg16Gly polymorphism and lifetime asthma (Tables 5 and ...Glu27Gln polymorphism contributed to wheeze or asthma irre- spective of maternal smoking during pregnancy or SHS (data not ...
10
Etanercept restores normal insulin signal transduction in β2-adrenergic receptor knockout mice
... insulin receptor substrate 1 (IRS-1) on serine 307 ...insulin receptor on tyrosine 960 which blocks the insulin receptor/IRS-1 interaction ...
6
Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling
... S1P receptor 3 [17-19]; 2) several studies, albeit in HEK 293 cells, have shown that angiotensin type 1A receptor-mediated regulation of RhoA activity is βarr-sensitive [37-39]; and 3) β2AR stimulation was ...
15
Enhancement of cardiac function after adenoviral mediated in vivo intracoronary β2 adrenergic receptor gene delivery
... β-adrenergic receptor (β-AR) signaling system, which mediates the inotropic and chronotrop- ic effects of the sympathetic transmitters epinephrine and norepinephrine, plays a critical role in the regula- ...
10
β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid derived suppressor cells
... elevated adrenergic tone is responsible for observed changes in immune cell populations, and overall promotes a pro- tumor milieu in the ...of adrenergic receptor signaling ...
17
EFFECT OF GLY 16 ARG SINGLE NUCLEOTIDE POLYMORPHISM ON AGONIST BINDING TO BETA 2 ADRENERGIC RECEPTOR – A STRUCTURAL PHARMACOGENOMIC APPROACH
... A shift in the position of the residues and difference in dihedral angles is noted between the proteins bearing glycine and arginine at position 16 respectively. The difference in the amino acid pattern as observed in ...
10
β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
... of receptor phosphorylation by G protein-coupled receptor kinases (GRKs) and recruitment of the multifunctional adapter protein, β-arrestin [13, ...initiate receptor desensitization, internalization, ...
13
GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility
... (D) Western blotting for GRK5 in total cardiac extracts from B1KO and β ARKct/B1KO (CT/KO) mice at 24 hrs and at 4 weeks (wks) post-MI. Representative blots of 4 independent experiments [r] ...
10
Phosducin influences sympathetic activity and prevents stress induced hypertension in humans and mice
... adrenergic receptor Adra1b, β1 adrenergic receptor Adrb1, and As 2 LD blocks separating PDC and PTGS2 were identified in the β2 adrenergic receptor Adrb2 mRNA was downregulated in aor- A[r] ...
17