Vaccine adjuvant
A Sendai Virus-Derived RNA Agonist of RIG-I as a Virus Vaccine Adjuvant
... the vaccine adjuvants developed so far exploit the PRR function to enhance vaccine ...RIG-I-based vaccine adjuvant will potentially mimic the PAMP generated during a natural infection and ...
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Rationally Designed TLR4 Ligands for Vaccine Adjuvant Discovery
... a vaccine adjuvant, as well as be alerted to activity that may lead to ...lipid adjuvant [GLA]), a synthetic TLR4 agonist currently being tested clinically in several component vaccines ...an ...
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Optimizing manufacturing and composition of a TLR4 nanosuspension: physicochemical stability and vaccine adjuvant activity
... In summary, the source of DPPC appears to have min- imal impact on the physicochemical characteristics and biological activity of GLA-AF. Buffered compositions may have slightly decreased the tendency for pH drift over ...
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Aminated nanomicelles as a designer vaccine adjuvant to trigger inflammasomes and multiple arms of the innate immune response in lymph nodes
... Abstract: In this study, we suggest a designer vaccine adjuvant that can mimic the drainage of pathogens into lymph nodes and activate innate immune response in lymph nodes. By the amination of multivalent ...
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The Mucosal Vaccine Adjuvant LT(R192G/L211A) or dmLT
... and vaccine antigens enhanced IL-17A and IL-13 secretion that was prevented when cultures included anti-IL-1  and anti-IL-23 neutralizing antibodies ...this adjuvant effect on PBMCs or isolated monocytes ...
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DEVELOPMENT AND IN VITRO CHARACTERIZATION OF NANOEMULSION AS ADJUVANT FOR THE ADMINISTRATION OF VACCINE USING A MODEL ANTIGEN
... With the advent of nanotechnology, vaccine formulations has gained lot of benefits. Nano particulates offers in large surface area, surface free energy, sustained & targeted delivery of therapeutics that ...
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Rist, Beate (2009): Beurteilung der Wirksamkeit einer Einfachvakzination bei Ferkeln in der 1. und 3. Lebenswoche mit Porcilis® PCV gegen das porcine Circovirus Typ 2 (PCV2) in einem Betrieb mit hohen maternalen Antikörpertitern.. Dissertation, LMU München: Tierärztliche Fakultät
... Lack of an effect of a commercial vaccine adjuvant on the development of postweaning multisystemic wasting syndrome (PMWS) in porcine circovirus type 2 (PCV2) experimentally infected c[r] ...
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Cross-Reactivity, Epitope Spreading, and De Novo Immune Stimulation Are Possible Mechanisms of Cross-Protection of Nonvaccine Human Papillomavirus (HPV) Types in Recipients of HPV Therapeutic Vaccines
... therapeutic vaccine (PepCan), which used a Candida skin test reagent (Candin; Nielsen Biosciences, San Diego, CA) as a novel vaccine adjuvant ...in vaccine (modified Vaccinia Ankara with ...
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Virus shedding after H9N2 strain challenge of SPF Chickens immunized by an experimental Nano-Adjuvant and commercial oil emulsion avian influenza (H9N2) vaccines
... the vaccine has afforded protection from other H9 ...the vaccine and field challenge virus should be ...nano-particle vaccine is able to provide 100% protective efficiency to SPF ...Razi® ...
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Immunological adjuvant effect of the peptide fraction from the larvae of Musca domestica
... excellent vaccine adjuvant properties in mouse models ...cious adjuvant, therefore, the current study was undertaken to evaluate the adjuvant potential of MDPF on the cellular and humoral ...
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Increasing the Potency of an Alhydrogel-Formulated Anthrax Vaccine by Minimizing Antigen-Adjuvant Interactions
... enthalpy ( ⌬ H). Isothermal titration calorimetry (ITC) was conducted in a VP-ITC titration microcalorimeter (MicroCal, United Kingdom). All samples were equilibrated by dialysis against the same buffer (150 mM NaCl [pH ...
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Evaluation of vaccine delivery systems for inducing long-lived antibody responses to Dermanyssus gallinae antigen in laying hens
... for 3 weeks without access to food. On-bird feeding trials were performed, according to methods previously described (Nunn et al., 2019). Brie fl y, sealed mesh feed- ing devices were constructed from 105 μm aperture ...
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Sublingual Adjuvant Delivery by a Live Attenuated Vibrio cholerae-Based Antigen Presentation Platform
... serotype vaccine strain in which the entire CTX phage, including the recombination sites, as well as the tcpA gene, has been ...attenuated vaccine strain expressing ...attenuated vaccine strain ...
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TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth
... model vaccine to adjuvant, because (a) PCV13 is a well-studied vaccine with known correlates of protection, which allows clear and unambigu- ous evaluation of our adjuvantation strategy; (b) current ...
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MontanideTM Gel01 ST Adjuvant Enhances PRRS Modified Live Vaccine Efficacy by Regulating Porcine Humoral and Cellular Immune Responses
... Current formulations of MLV do not contain adjuvants since the multiplication and infectious properties of at- tenuated live PRRS virus have been shown to induce suf- ficient protection to PRRSV infection [6]. However, ...
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Properties and applications of nanoparticle/microparticle conveyors with adjuvant characteristics suitable for oral vaccination
... with adjuvant characteristics are described with regard to their potential importance for oral immunization, and some promising and successful modification strategies are ...oral vaccine, NP/MP conveyors, ...
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Oral Vaccine Formulations Stimulate Mucosal and Systemic Antibody Responses against Staphylococcal Enterotoxin B in a Piglet Model
... approved vaccine against staphylococcal enterotoxin B (SEB) ...subunit vaccine candidates due to the lack of superantigen activity of native SEB in rodents and due to the limitations of primate ...toxin ...
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Current state of treatment for primary cutaneous melanoma
... the adjuvant therapy of high-risk melanoma outside clinical ...surgical adjuvant ther- apy in patients with stage III or IV melanoma, Spitler et ...peptide vaccine) among patients with resectable ...
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Waning Immunity and Microbial Vaccines—Workshop of the National Institute of Allergy and Infectious Diseases
... characterizing vaccine-induced protection that can inform development of vaccine formulations for distinct and vulnerable ...candidate adjuvant systems, Ags, and possible formulations, large-scale ...
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Oral Vaccine Formulations Stimulate Mucosal and Systemic Antibody Responses Against Staphylococcal Enterotoxin B Using a Piglet Model.
... determine oral vaccine formulations against SEB. Seven-day-old mixed gender commercial crossbred piglets (N=40 per trial) were obtained from Spring Meadow Farms (Springfield, NC) and individually housed in 0.6 x ...
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