vaccine candidate
Leishmanial Excretory-Secretory proteins: A potent vaccine candidate
... Stage-Dependent Expression of a Secretory Serine Protease in Leishmania donovani and Its Role as a Vaccine Candidate). The main target of formulating a vaccine is to activate the strong immunity ...
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A Plant-Produced Pfs230 Vaccine Candidate Blocks Transmission of Plasmodium falciparum
... Plasmodium falciparum is transmitted to a new host after completing its sexual cycle within a mosquito. Developing vaccines against the parasite sexual stages is a critical component in the fight against malaria. We are ...
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Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate
... the vaccine candidate by intracranial injection was safe and that the virus was unable to infect Aedes aegypti mosquitoes because of its decreased level of viral RNA synthesis and increased sensitivity to ...
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Comparative immunogenicity of preparations of yeast-derived dengue oral vaccine candidate
... Establishment of a memory response is an important criterion in designing and implementing an effective vaccine. Our studies revealed that feeding recombinant LTB-scEDIII WC or CFE to mice stimulated a primary ...
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Genetic Variation In Vitro and In Vivo of an Attenuated Lassa Vaccine Candidate
... Lassa vaccine candidate ML29 is a laboratory-produced reassortant between Lassa and Mopeia viruses, two Old World arenaviruses that differ by 40% in nucleic acid ...virus vaccine candidate ...
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Characterization of Brucella abortus mutant strain Δ22915, a potential vaccine candidate
... [50]. This result suggested that testing whether mutant strain ∆22915 could be applied as a vaccine would be a worthwhile study. Vaccination with the mutant strain induced an effective immune response against the ...
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Increased Genetic and Phenotypic Stability of a Promising Live-Attenuated Respiratory Syncytial Virus Vaccine Candidate by Reverse Genetics
... in vaccine recipients, they were not associated with enhanced repli- cation or disease, reflecting the fact that by retaining four of the five original attenuating features, the revertants remained highly ...
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The Cytauxzoon felis Genome: A Guide to Vaccine Candidate Antigen Discovery for Cytauxtzoonosis.
... Cytauxzoonosis, caused by the protozoan parasite Cytauxzoon felis, is an emerging infectious disease of high morbidity and mortality in domestic cats (Felis catus) that is expanding in territory. Currently there is no ...
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Kinesin Motor Domain of Leishmania donovani as a Future Vaccine Candidate
... DNA vaccine construct expressing the kinesin motor domain for immunization in BALB/c ...DNA vaccine construct ex- pressing the kinesin motor domain of ...this vaccine construct were significantly ...
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A Measles Virus-Based Vaccine Candidate Mediates Protection against Zika Virus in an Allogeneic Mouse Pregnancy Model
... Viremia in the plasma of ZIKV-infected mice was analyzed by quantitative PCR (qPCR) (Fig. 4F and G) using the WHO international ZIKV RNA standard for normaliza- tion. Among mock-vaccinated control animals, ZIKV genomes ...
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Cost-effectiveness of a potential Zika vaccine candidate: a case study for Colombia
... Zika vaccine. Currently, there are a number of vaccine candidates being investigated using a variety of vaccine platforms [13], including purified inacti- vated, live attenuated, viral-vectored, ...
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A malaria vaccine candidate based on an epitope of the Plasmodium falciparum RH5 protein
... Several groups have shown that the intact PfRH5 protein, whether administered as a recombinant protein or expressed from viral vectors, elicits antibodies that inhibit parasite entry into erythrocytes in vitro ...
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Optimizing expression of the pregnancy malaria vaccine candidate, VAR2CSA in Pichia pastoris
... Pregnancy-associated malaria (PAM) is an important cause of maternal anaemia, stillbirth, and delivery of low birth weight children in malaria endemic regions [1]. PAM is characterized by the selective accumulation of ...
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Construction of Mtb72F Plasmid as a DNA Vaccine Candidate for Mycobacterium tuberculosis
... potential candidate for stimulating T cell immunity ...a vaccine candidate is its rapid secretion after translation (13), because post- translational modifications produce different protein isoforms ...
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Deletion of nuoG from the Vaccine Candidate Mycobacterium bovis BCG ΔureC::hly Improves Protection against Tuberculosis
... Gene expression analysis of dLNs in BCG ⌬ ureC::hly- and BCG ⌬ureC::hly ⌬nuoG-vaccinated mice. Microarray analyses FIG 4 Deletion of nuoG in the clinical vaccine candidate, BCG ⌬ ureC::hly, further improves ...
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KSAC, the First Defined Polyprotein Vaccine Candidate for Visceral Leishmaniasis
... a vaccine composed of multiple antigens rather than a single gene product is more likely to elicit a protective immune response against leishmaniasis in a broad spectrum of ...the vaccine candidate ...
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Gp96 rich lysate as a vaccine candidate against infection with Salmonella typhimurium
... Our results showed that an immunization with gp96 rich lysate of liver and spleen cells of mice infected with S. typhimurium effectively induces protection against S. typhimurium. Zhang et al immunized the mice with ...
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Group A Streptococcal Peptides expressed in HBsAg-S VLPs as a vaccine candidate
... 30-valent vaccine candidate currently in trials is inappropriately specialised to serotypes present in areas with low GAS incidence, such as the United ...
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9-2-2015 12:00 AM A Plant-Made Vaccine Candidate To Protect Ruminants Against Shiga Toxin-Producing Escherichia Coli
... this vaccine candidate will not be elucidated until these future experiments are complete, several considerations of this vaccine can be postulated and may need to be addressed in the ...
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Cellulose-Affinity Isolation of Vaccine Candidate Antigens from Transgenic Plants
... Efficient purification of biomedical proteins grown through heterologous expression in plants is a major challenge. This challenge is primarily complicated due to low yield (compare to microbial systems) of target ...
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