Vaccine-derived polioviruses
Highly Divergent Type 2 and 3 Vaccine-Derived Polioviruses Isolated from Sewage in Tallinn, Estonia
... poliovirus vaccine (OPV) to inac- tivated poliovirus vaccine (IPV) in 2008 ...of vaccine-associated paralytic poliomyelitis (VAPP) in OPV recipients or contacts (7) and the emergence of genetically ...
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The detection of 3 ambiguous type 2 vaccine derived polioviruses (VDPV2s) in Uganda
... The three VDPVs shared the R103K mutation that could be linked to a natural selection process. The mutation I143T was common to Kamuli and Kween and has been reported in all the polioviruses that were detected ...
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Use of a Multiple Restriction Fragment Length Polymorphism Method for Detecting Vaccine Derived Polioviruses in Clinical Samples
... pathogenic vaccine-derived polio- viruses (VDPV) presenting >1% nucleotide divergence from the sequence of the original vaccine strain have been demonstrated in certain ...poliovirus ...
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Multiple Independent Emergences of Type 2 Vaccine-Derived Polioviruses during a Large Outbreak in Northern Nigeria
... strain, derived from a WPV isolate with intrinsically low neurovirulence and subjected to the shortest selection pathway to attenuation (94), retained more of the biological properties of its WPV parent than did ...
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Antigenic Evolution of Vaccine-Derived Polioviruses: Changes in Individual Epitopes and Relative Stability of the Overall Immunological Properties
... of vaccine recipients might indeed contribute to the observed changes (see below), some of our data (dis- cussed below) suggest that this contribution, if any, was hardly a decisive ...
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Characterization of four vaccine related polioviruses including two intertypic type 3/type 2 recombinants associated with aseptic encephalitis
... poliovirus vaccine (OPV) consists of three live attenu- ated strains that correspond to the three serotypes of poliovirus (Sabin 1, 2, and 3, for Polio 1, 2, and 3, re- spectively) ...the ...
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Characterization of outbreak response strategies and potential vaccine stockpile needs for the polio endgame
... circulating vaccine-derived polioviruses (cVDPVs) ...poliovirus vaccine (IPV) for outbreak re- ...immunodeficiency-associated vaccine-derived po- lioviruses (iVDPVs) and ...
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Molecular and Antigenic Characterization of a Highly Evolved Derivative of the Type 2 Oral Poliovaccine Strain Isolated from Sewage in Israel
... and vaccine- derived polioviruses (4, 5, 11, 12, 15; ...wild polioviruses, nucleotide substitutions accumulate at a rate of approximately 1% per year and consist primarily of changes at ...
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Serological survey on immunity status against polioviruses in children and adolescents living in a border region, Apulia (Southern Italy)
... or vaccine-derived polioviruses or to the unintentional or intentional release of poliovirus from a laboratory or vaccine ...poliovirus vaccine (mOPV), many questions remain concerning ...
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Detection of Emerging Vaccine Related Polioviruses by Deep Sequencing
... poliovirus vaccine (OPV), which has been the backbone of polio eradication efforts worldwide due to its ease of administration, immunogenic potential, and low cost ...causes vaccine-associated paralytic ...
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Limited and Localized Outbreak of Newly Emergent Type 2 Vaccine-Derived Poliovirus in Sichuan, China
... poliovirus vaccine (OPV) for more than 6 decades has reduced the worldwide incidence of polio by ⬎ 99%; type 2 wild poliovirus (WPV) was eliminated globally in 1999 (1), no type 3 WPV has been reported since 2012, ...
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Neisseria meningitidis PorB, a Toll-Like Receptor 2 Ligand, Improves the Capacity of Francisella tularensis Lipopolysaccharide To Protect Mice against Experimental Tularemia
... promising vaccine candidate should not present any indica- tion of illness, but we speculate that future conjugation of ...the vaccine candidate that we ...a vaccine prepared by use of this approach ...
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Models Derived from In Vitro Analyses of Spleen, Liver, and Lung Leukocyte Functions Predict Vaccine Efficacy against the Francisella tularensis Live Vaccine Strain (LVS)
... leukocytes derived from lungs and livers of mice immunized by parenteral and respiratory routes with ...leukocytes derived from intradermally and intranasally vaccinated mice controlled in vitro Francisella ...
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High Throughput Next Generation Sequencing of Polioviruses
... ABSTRACT The poliovirus (PV) is currently targeted for worldwide eradication and containment. Sanger-based sequencing of the viral protein 1 (VP1) capsid region is currently the standard method for PV surveillance. ...
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Immunogenicity of a Plasma Derived Hepatitis B Vaccine in Children and Adults
... Immunogenicity of a Plasma derived Hepatitis B Vaccine in Children and Adults ORIGINAL ARTICLE Immunogenicity of a Plasma derived Hepatitis B Vaccine in Children and Adults M Sinniah, MRCPath* M Halim[.] ...
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Intestinal trypsin can significantly modify antigenic properties of polioviruses: implications for the use of inactivated poliovirus vaccine.
... 3749-3753 0022-538X/87/123749-05$02.00/0 Copyright C 1987, American Society for Microbiology Intestinal Trypsin Can Significantly Modify Antigenic Properties of Polioviruses: Implication[r] ...
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Vaccine related poliovirus shedding in trivalent polio vaccine and human immunodeficiency virus status: analysis from under five children
... enrolled in the study were below the age of 5 years. Medi- cal records at the orphanage were reviewed to identify each child’s HIV status and obtain age, sex, and immu- nization data. Final HIV infection status of the ...
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Increased Genetic and Phenotypic Stability of a Promising Live-Attenuated Respiratory Syncytial Virus Vaccine Candidate by Reverse Genetics
... licensed vaccine or effective antiviral therapy for RSV (9), although infants and young children at high risk for severe RSV disease can be substantially protected by passive immunoprophylaxis with ...
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Limited duration of vaccine poliovirus and other enterovirus excretion among human immunodeficiency virus infected children in Kenya
... of vaccine-related poliovirus shedding in HIV-infected indi- viduals, the prospective design and the availability of serial specimens in this study allowed us to evaluate the duration of viral shedding after each ...
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NEUTRALIZING ANTIBODY TO POLIOVIRUSES IN NORMAL HUMAN URINE
... Neutralizing activity was not detected in any of the urine concentrates by either test in the absence of antibody in the corresponding serum, except on one occasion in Subject 13 before [r] ...
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