vaccine trial
Salivary antibodies induced by the seven valent PncOMPC conjugate vaccine in the Finnish Otitis Media Vaccine Trial
... pneumococcal_conjugate_raccines_recomm_nov_2003.p df. However, the value is a rough estimate and further, the function of antibodies, both opsonophagocytic activity and avidity, and immunological memory are also essen- ...
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Validation of nested Bordetella PCR in pertussis vaccine trial
... A further validation of the specificity comprised the 2,159 culture-negative aspirates, among which 83 extra aspirates were PCR positive for B. pertussis. Among these aspirates, there were only five whose patients did ...
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Analysis of HLA A*02 Association with Vaccine Efficacy in the RV144 HIV-1 Vaccine Trial
... the vaccine exerted immune pressure on the V1/V2 region, Rolland et ...HIV-infected trial participants in the vaccine group versus the placebo group—showed genetic differences relative to the ...
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The aftermath of the Merck's HIV vaccine trial
... the vaccine inoculated groups ...HIV vaccine trial, the rationale was based on a preclinical vaccine study in rhe- sus macaques monkeys (Macaca mulatta) primed with a plasmid expression vector ...
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Simian immunodeficiency virus DNA vaccine trial in macaques.
... Expression of vaccine DNAs. In vitro expression of vaccine DNAs was tested by protein blot analyses of transiently transfected COS cells. Purified plasmid DNAs were transfected into COS cells with a Gene ...
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PURIFIED INFLUENZA VACCINE TRIAL IN A CHILDREN'S HOME
... cases the users have felt that the reactions were just about as severe as the relatively mild disease itself.” Clazier and co-workers reported local reactions in 100% of 614 in- fants an[r] ...
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Live Attenuated Influenza Virus Vaccine Trial in Children
... The one child with a low antibody titer, who did not respond to the vaccine, was given a second identical dose six weeks later, and devel- oped a rise from < 4 to 512.. The geometric [r] ...
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HIV-Exposed Infants Vaccinated with an MF59/Recombinant gp120 Vaccine Have Higher-Magnitude Anti-V1V2 IgG Responses than Adults Immunized with the Same Vaccine
... infant vaccine trials have demonstrated that HIV-1 immunization of infants is safe and can induce both cellular and humoral immune responses (13, ...HIV vaccine efficacy trial has been conducted to ...
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Using infective mosquitoes to challenge monkeys with Plasmodium knowlesi in malaria vaccine studies
... Plasmodium knowlesi infections in rhesus monkeys have been used as a model system to test malaria vaccines [5-24]. The advantages of this model system are that the immune systems of rhesus monkeys and humans are simi- ...
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Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria - A comprehensive pro-poor health policy and strategy for the developing world
... any vaccine trial that does not control for worm infections could be fl awed, neglected tropical disease control should be linked with big three vaccine development efforts, such as those sponsored by ...
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Cost-Effectiveness Analysis of an Intranasal Influenza Vaccine for the Prevention of Influenza in Healthy Children
... intranasal vaccine is licensed for general use for a broader age range than that included in our clinical trial, then a greater pro- portion will receive only 1 dose per year, therefore increasing its ...
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Safety and Immunogenicity of a Recombinant Borrelia burgdorferi Outer Surface Protein A Vaccine Against Lyme Disease in Healthy Children and Adolescents: A Randomized Controlled Trial
... A total of 4090 participants, ages 4 through 18 years, were randomized, 3065 in group V and 1025 in group P. Three participants withdrew after consent was obtained but before the first dose of vaccine was given. ...
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Effect of HIV Envelope Vaccination on the Subsequent Antibody Response to HIV Infection
... 1 trial, n ⫽ 1), HVTN 086 (subtype C, DNA/MVA/ gp140 protein, phase 1 trial, n ⫽ 2), and HVTN 204 (multisubtype, DNA/adenovirus serotype 5 [Ad5], phase 2 trial, n ⫽ 7) and 4 placebo ...that ...
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Pneumonia A Dreadful Disease
... conjugate vaccine in children younger than 5 years of age for prevention of pneumonia: updated analysis using World Health Organization standardized interpretation of chest ...
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Strategies for Improving Vaccine Delivery: A Cluster-Randomized Trial
... This study was designed as a single- blinded (to outcomes assessor), cluster-randomized, parallel trial. Recruitment occurred from January to June 2013 before the start of the intervention. To gain a diverse ...
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Safety and Immunogenicity of a Recombinant Influenza Vaccine: A Randomized Trial
... The study was designated as an exploratory study; thus, the final sample size was not based on statistical calculations. We initially planned to enroll 150 subjects in each age cohort, randomly assign 1:1 to the RIV4 or ...
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The effect of Rift Valley fever virus Clone 13 vaccine on semen quality in rams
... the trial by Dungu et ...present trial, animals were kept outdoors during the early Karoo summer, and had to contend with significant variation in environmental ...
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Innovations in the quantitative virus outgrowth assay and its use in clinical trials
... is pre-screening of donor PBMCs for CCR5 expression level and selecting for high CCR5-expressing donors only. Another option is using cells from matched donor- patient pairs that are shown in vitro to exhibit robust ...
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Acellular Pertussis Vaccines: Recommendations for Use as the Fourth and Fifth Doses
... A comparative trial of the reactogenicity and immunogenicity of Takeda acellular pertussis vaccine combined with tetanus and diphtheria toxoids: outcome in 3- to 8-. month-old infants, 9[r] ...
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Enrolling study personnel in Ebola vaccine trials: from guidelines to practice in a non epidemic context
... a trial, in both the scientific literature and the regulatory ...clinical trial, es- pecially in low-income settings and in emergency situa- tions ...community trial for which the staff may meet the ...
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