Vascular leakage
Macular and optic disc edema and retinal vascular leakage in familial amyloid polyneuropathy with a transthyretin Val30Met mutation: a case report
... retinal vascular leakage including optic disc and macular edema in a patient with familial amyloid ...with leakage in the posterior pole and mid-periphery, without vitreous ...
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Therapeutic effect of apatinib-loaded nanoparticles on diabetes-induced retinal vascular leakage
... retinal vascular hyperpermeability and subsequent macular edema during the progression of diabetic retinopathy and diabetic macular edema, we determined whether Apa-HSA- PEG nanoparticles could inhibit ...
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Sac-1004, a vascular leakage blocker, reduces cerebral ischemia—reperfusion injury by suppressing blood–brain barrier disruption and inflammation
... retinal vascular leakage, and reduced tumor vascular hyperpermeability induced by vascular endothe- lial growth factor (VEGF), histamine, and thrombin in vitro ...block vascular ...
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Regulatory mechanisms, prophylaxis and treatment of vascular leakage following severe trauma and shock
... reduce vascular generation, promote oxidative stress, weaken vasodila- tory effects and generate reactive oxygen species ...promoting vascular leakage and maintaining equilibrium in ...increase ...
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Thromboxane mediated hypertension and vascular leakage evoked by low doses of Escherichia coli hemolysin in rabbit lungs
... severe vascular leakage in isolated lungs in the absence of circulating inflammatory cells and humoral mediator systems, mimicking the key events in the development of acute respiratory failure in states of ...
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The synthetic Tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis
... Since the original report by Witzenbichler and collea- gues [11] in 2005, several studies have confirmed that activation of the non-redundant and endothelial-specific Tie2 receptor pathway by adenoviral overexpression of ...
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CNS-border associated macrophages respond to acute ischemic stroke attracting granulocytes and promoting vascular leakage
... BAMs are players at the interface between the nervous system and the immune system [6, 12, 27, 29, 34, 37, 53]. However, the precise functions of these cells under pathological conditions remain largely unknown. This ...
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Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium-specific FAK-kinase dead mice
... vessel leakage, mice were injected ante mortem with Hoechst dye and ...PE-PECAM. Leakage was analysed by mea- suring the Hoechst area relative to the endothelial PE-PECAM-positive area, and showed no ...
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Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice
... Murine cerebral malaria is associated with increased expression of eCAMs as well as leukocyte and platelet accumulation in brain vessels leading to microvascular damage and BBB breakdown [8,30]. Here we show that ...
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Dengue virus non-structural protein 1: a pathogenic factor, therapeutic target, and vaccine candidate
... of endogenous lipoprotein particles [18]. Accumulation of secreted NS1 in DHF/DSS patient sera has been observed during the critical phase [20]. The serum concentration of NS1 in DHF/DSS patients can reach as high as 50 ...
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Vaccination against Pseudomonas aeruginosa Pneumonia in Immunocompromised Mice
... of vascular leakage in the Cy-treated mice in- fected with strain 9882-80 compared to nontreated mice also infected with 9882-80 were not related to the Cy treatment itself, as Cy-treated mice given PBS ...
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DSGOST inhibits tumor growth by blocking VEGF/ VEGFR2‑ activated angiogenesis
... In this study, we investigated whether DSGOST inhibits angiogenesis, especially VEGF‑induced tumor angiogenesis. DSGOST suppressed VEGF‑induced endothelial cell migration, tube formation and invasion without affecting ...
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Study of the effect of grid laser photocoagulation on contrast sensitivity in patients with diabetic macular odema.
... The goal of macular laser photocoagulation is to limit vascular leakage through focal laser burns of leaking microaneuyrsm or grid laser burns in areas of diffuse break down of the blood[r] ...
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Lack of chronic neuroinflammation in the absence of focal hemorrhage in a rat model of low-energy blast-induced TBI
... of vascular leakage did not show obvious microgliosis, as shown by the relatively low abundance of Iba1 + reactive or amoeboid microglia (types 3 and 4) expressing MHCII, and did not present major ...
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Critical Role of Airway Macrophages in Modulating Disease Severity during Influenza Virus Infection of Mice
... In the context of influenza virus infections, mononuclear phagocytes recruited to inflamed lung tissues in a CCR2-de- pendent manner (26) can contribute to alveolar epithelial cell apoptosis by the release of tumor ...
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von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish
... increased vascular endothelial growth factor (Vegf ) signaling in vhl ...that vascular abnormalities in the vhl –/– retina lead to vascular leakage, severe macular edema and retinal ...
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Original Article FK506 alleviates blood-retinal barrier breakdown and reduces retinal vascular permeability in early streptozotocin-induced diabetic rat
... DR is the leading cause of blindness in patients 20-70 years of age. The detailed mechanism of DR remains largely unknown. However, the breakdown of the inner endothelial BRB and subsequent retinal vascular ...
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Does Coupling Affect the Security of Masked Implementations?
... HD leakage if the security proofs assume Hamming Weight (HW) ...static leakage is measurable ...HD leakage and redundant toggling of gates from other failures of independent leakage, we ensure ...
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Leakage-Resilient Certificateless Signature Under Continual Leakage Model
... numerous leakage-resilient cryptographic schemes have been ...studying leakage-resilient certificateless cryptographic ...first leakage-resilient certificateless signature (LR-CLS) scheme under the ...
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Prevention of Information Leakage
... ABSTRACT: A data distributor has given sensitive data to a set of supposedly trusted agents (third parties). Some of the data are leaked and found in an unauthorized place (e.g., on the web or somebody’s laptop). The ...
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