vascular remodeling
Adult Stem Cells in Vascular Remodeling
... human vascular remodeling has evolved, two therapeutic angles have arisen: 1) influencing endogenous VSC behavior to prevent initiation and progression of disease, and 2) exogenous stem cell delivery to ...
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Pulmonary hypertension and vascular remodeling in mice exposed to crystalline silica
... in vascular smooth muscle cells represented an early event in vascular disease in experi- mental type I diabetes ...hand, vascular cells expressing nestin were implicated in the develop- ment of ...
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Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMα) in chronic hypoxia- and antigen-mediated pulmonary vascular remodeling
... the vascular tissue du- ring inflammation-induced remodeling would suggest that HIMF may be acting on the vasculature through an indirect ...the remodeling peribronchial blood ...
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The association of neuron-derived orphan receptor 1 with pulmonary vascular remodeling in COPD patients
... Results: COPD patients with hypoxemia showed significantly enlarged pulmonary vessels wall thickness and increased protein levels of HIF-1 α , smooth muscle actin, cyclin D1, and NOR1 when compared with those in normoxic ...
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Activation of Nrf2 Attenuates Pulmonary Vascular Remodeling via Inhibiting Endothelial-to-Mesenchymal Transition: an Insight from a Plant Polyphenol
... EndMT is a phenotypic change during which endothelial cells lose endothelial phenotype and gain more invasive and migratory properties. Ranchoux et al [7] demonstrated that EndMT is involved in pulmonary vascular ...
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Vascular remodeling of the mouse yolk sac requires hemodynamic force
... hierarchical vascular branching pattern with enlarged avascular spaces was observed in yolk sacs after 24 hours in culture ...the vascular space ...islands, vascular remodeling did not take ...
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Vascular remodeling and the kallikrein kinin system
... after vascular injury, kinins mediate the beneficial effect of angiotensin-converting enzyme inhibitors that prevent neointima ...of vascular remodeling and disease, while increased activ- ity may ...
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Direct evidence for the importance of endothelium derived nitric oxide in vascular remodeling
... for vascular disease in mice, we applied a model of vascular remodeling previously used in rats and rabbits to ...to remodeling seen in the same model in rats and ...lumenal remodeling ...
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Tie1 controls angiopoietin function in vascular remodeling and inflammation
... inflammatory vascular remodeling, and vessel ...promotes vascular stabilization in inflammation and sepsis, whereas ANG2 is a context-dependent Tie2 agonist or ...ANG-induced vascular ...
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Hemodynamics, inflammation, vascular remodeling, and the development and rupture of intracranial aneurysms: a review
... pro-inflammatory/pro-matrix remodeling properties and subsequent Fas-mediated apoptotic cell death lead to the arterial wall weakening and aneurysm formation and ...inflammation, vascular remodeling, ...
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Strain dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II–deficient mice
... after vascular interventions (43, ...of vascular remodeling (47–50) is known to enhance NF-κB activa- tion, there is a possibility that the action of thrombin on migra- tion and proliferation of ...
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Hypoxia induced pulmonary vascular remodeling: a model for what human disease?
... the vascular wall would involve the direct trans- differentiating of endothelial cells into ...during vascular remodeling in hypoxic hyper- ...
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Inhaled corticosteroid normalizes some but not all airway vascular remodeling in COPD
... In summary, this longitudinal, repeat bronchoscopy study, for the first time has attempted an evaluation of the effects of ICS on airway vessel remodeling in COPD. LP, but not Rbm vessels, seem responsive to ...
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Inhibition of receptor tyrosine kinases restores immunocompetence and improves immune dependent chemotherapy against experimental leishmaniasis in mice
... Here, we provide the first direct evidence to our knowledge of vascular remodeling in the spleens of mice infected with L. donovani and show that treatment with the clinically validated RTKI suni- tinib ...
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HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P1) promotes regeneration and suppresses fibrosis in the liver
... Regeneration of hepatic sinusoidal vasculature is essential for non-fibrotic liver regrowth and restoration of its metabolic capacity. However, little is known about how this specialized vascular niche is ...
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Molecular physiopathogenetic mechanisms and development of new potential therapeutic strategies in persistent pulmonary hypertension of the newborn
... and vascular growth in neonatal rodents models of lung injury induced by chronic hyperoxia ...and vascular damage and stimulate prolif- eration and differentiation of resident epithelial and endo- thelial ...
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Catalpol Increases Brain Angiogenesis and Up-Regulates VEGF and EPO in the Rat after Permanent Middle Cerebral Artery Occlusion
... EPO is a pleiotropic factor [39]. EPO and EPO receptor (EPO-R) are expressed in neurons, astrocytes, and endothelial cells after focal permanent ischemia in mice. EPO is a neuroprotective factor [40-41], which improves ...
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The von Hippel–Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice
... Mutation of the von Hippel–Lindau (VHL) tumor suppressor protein at codon 200 (R200W) is associated with a disease known as Chuvash polycythemia. In addition to polycythemia, Chuvash patients have pulmonary hypertension ...
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Fluoxetine Protects against Big Endothelin 1 Induced Anti Apoptosis by Rescuing Kv1 5 Channels in Human Pulmonary Arterial Smooth Muscle Cells
... monary remodeling. Vascular remodeling has been confirmed to be a hallmark pathological feature of PAH, and is characterized by changes in the pulmonary vascular structures associated with ...
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VIP and endothelin receptor antagonist: An effective combination against experimental pulmonary arterial hypertension
... Background: Pulmonary Arterial Hypertension (PAH) remains a therapeutic challenge, and the search continues for more effective drugs and drug combinations. We recently reported that deletion of the vasoactive intestinal ...
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