VEGF mRNA
Downregulation of VEGF mRNA expression by triamcinolone acetonide acetate-loaded chitosan derivative nanoparticles in human retinal pigment epithelial cells
... of VEGF mRNA expression by TAA/DA- Chit nanoparticles was further investigated by real-time reverse transcription polymerase chain reaction (RT-PCR) assay of the treated human retinal pigment epithelial ...
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Regional differences in expression of VEGF mRNA in rat gastrocnemius following 1 hr exercise or electrical stimulation
... in VEGF mRNA demon- strated here underlie either 1) regional differences in cap- illarity or 2) regional differences in exercise induced angiogenesis cannot be determined from our ...that VEGF ...
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Myc regulates VEGF production in B cells by stimulating initiation of VEGF mRNA translation.
... increased VEGF mRNA translation (Kevil et ...increased VEGF mRNA translation on polysomes (Chung et ...and VEGF production, indicating that mTOR is an important mediator of VEGF ...
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Original Article Thymoquinone (TQ) inhibits corneal neovascularization in a rabbit model
... agreement, VEGF-positive rates in TQ groups were signifi- cantly lower compared with values obtained for Group T, as shown by immunohistochemistry; in addition, VEGF mRNA levels were lower in TQ ...
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Hypoxic stabilization of mRNA is HIF-independent but requires mtROS
... of VEGF mRNA in particular has been stud- ied in multiple cell types [24, 28–32], and is thought to involve AU Rich Ele- ments (AREs) and the RNA binding proteins (RBPs) HuR, PTB, hnRNPL, and others [24, ...
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Post-transcriptional modifications of VEGF-A mRNA in non-ischemic dilated cardiomyopathy
... of VEGF-A may be influenced by the amount and type of isoforms, which are determined by alternative splicing of mRNA [1, 2, ...particular VEGF-A isoforms is determined and regulated by metabolic ...
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Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells
... Cyclic Adenosine Monophosphate Analogs Stimulate Vascular Endothelial Growth Factor mRNA Expression Because adenosine receptor agonists increased cAMP levels and VEGF mRNA expression in [r] ...
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Andrographolide inhibits hypoxia-inducible factor-1 through phosphatidylinositol 3-kinase/AKT pathway and suppresses breast cancer growth
... To further confirm Andro’s effect on HIF-1 in vivo, we evaluated HIF-1 α levels in MDA-MB-231 tumors using Western blotting and qPCR assays. In accordance with in vitro results, HIF-1 α accumulation was significantly ...
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Preserved vascular integrity and enhanced survival following neuropilin-1 inhibition in a mouse model of CD8 T cell-initiated CNS vascular permeability
... that VEGF mRNA is expressed predominantly in neurons, as early as two hours post-induction of CD8 T cell-initiated ...of VEGF receptor flk-1 significantly increasing shortly ...of VEGF, ...
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4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expression
... TP mRNA expression and treatment with a TP inhibitor could block angiogenesis in those cell ...express VEGF mRNA, TP mRNA expression was significantly decreased by 4-MU treatment, suggesting ...
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Tumor-associated antigen CAPER and microvessel density in hepatocellular carcinoma
... of VEGF mRNA and changes in ratios of alternatively spliced VEGF isoforms lead to increased or decreased microvessel formation [8, 10], we examined microvessel density in HCC and normal liver using ...
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Butyrate suppresses expression of neuropilin I in colorectal cell lines through inhibition of Sp1 transactivation
... down-regulates VEGF at the mRNA and protein ...reduced VEGF mRNA expression compared to untreated cells in HCT116 and Caco-2 cell lines whereas there was no significant difference of ...
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Yiguanjian decoction and its ingredients inhibit angiogenesis in carbon tetrachloride induced cirrhosis mice
... including VEGF, PDGF and FGF [4, 14]. In particu- lar, 70–80 % expression of VEGF mRNA depends on HIF- 1α ...gene, VEGF, at the protein and mRNA levels. Biological activity of ...
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Isolation of mimotopes to the anti human VEGF antibody Bevacizumab by mRNA display using random peptide libraries and the vaccination of a rabbit
... An mRNA display system using synthetic DNA coding for random 10- and 20-amino-acid peptide libraries was employed to isolate mimotopes that could substi- tute for the anti-human VEGF antibody ...human ...
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Exercise-induced expression of angiogenic growth factors in skeletal muscle and in capillaries of healthy and diabetic mice
... The expression of Cyr61 was also increased in diabetic muscles. Cyr61 (also known as CCN1) is an important regulator of angiogenesis, endothelial cell function and ECM modulation [44,45]. It also regulates the activity ...
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Expression of MT 1 MMP, MMP2, MMP9 and TIMP2 mRNAs in Ductal Carcinoma in Situ and Invasive Ductal Carcinoma of the Breast
... MMP/TIMP mRNA expression was mainly noted in tumor cells rather than in stromal cells and displayed strong intensity at the interface between tumor cell nests and the interstitial ...
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Obesity-associated insulin resistance is correlated to adipose tissue vascular endothelial growth factors and metalloproteinase levels
... [15]. VEGF-A (17- 23 kDa) is a major angiogenic factor that stimulates pro- liferation and migration of ECs ...[16]. VEGF-B (21 kDa) is 43% identical to VEGF-A; it also promotes angiogenesis and is ...
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Crosstalk between the HIF-1 and Toll-like receptor/nuclear factor-κB pathways in the oral squamous cell carcinoma microenvironment
... and VEGF in HSC3 and SCC4 cells in a time-dependent manner (Figure 2C– 2D), suggesting that TLR pathway activation resulted in upregulation of HIF-1α and VEGF ...and VEGF expression, we knocked down ...
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EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR A AND ITS RECEPTORS IN UTEROPLACENTAL TISSUES OF THE NORMOTENSIVE AND HYPERTENSIVE PREGNANT RAT
... Paraffin embedded tissues were used to detect mRNA VEGF-A using the technique of insitu hybridisation. The sections were dewaxed (histolene X 2 for 4 minutes) and rehydrated (100% ethanol X 2 for 4 minutes, ...
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The Expressions of P53, MDM2 in Trophoblasts of Spontaneous Abortion Mouse Model and the Relevant Researches
... the mRNA expression of the related genes of p53, MDM2, vascular endothelial growth factor (VEGF) and hypoxia inducible transcription factors-1 a (HIF-la) in villous samples of spontaneous abortion mouse ...
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