VEGF/PDGF
Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain
... the VEGF/PDGF signaling systems in the hippocampus that were reversible by CTS and THA ...administration. VEGF is a hypoxia-inducible secreted protein that interacts with receptor tyrosine kinases ...
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Siedlecki, Jakob (2019): Combined inhibition of vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) for neovascular AMD in vitro. Dissertation, LMU München: Medizinische Fakultät
... Da PDGF den wichtigsten Proliferationsimpuls und das wichtigste Chemokin im Rahmen dieser Rekrutierung von Perizyten Richtung CNV darstellt, könnte Axitinib eventuell auch in Zukunft in vivo die gerichtete ...
37
The BPD trio? Interaction of dysregulated PDGF, VEGF, and TGF signaling in neonatal chronic lung disease
... a VEGF- dependant improvement in microvascular structure and function ...of VEGF to the ECM [78]; second, the bone morphogenic protein (BMP), part of the TGF-β superfamily, enhances secretion of the ...
7
Wuchrer, Alexander (2012): Therapeutische Angiogenese durch Kotransfektion von VEGF-A und PDGF-B bei chronischer myokardialer Ischämie am Schweineherz. Dissertation, LMU München: Medizinische Fakultät
... von VEGF-A ...Wenn VEGF-A nun aber mittels AAV transduziert wurde, kam es in den Hinterläufen von Ratten zu einer Stimulation der Angiogenese und dadurch zu einer Verbesserung der ...von VEGF-A ...
95
Serial measurements of serum PDGF-AA, PDGF-BB, FGF2, and VEGF in multiresistant ovarian cancer patients treated with bevacizumab
... serum VEGF levels and poor ...low VEGF values; however, the median VEGF levels are used in most of the ...serum VEGF in the upper 4th quartile and poor OS, which is con- sistent with our ...of ...
8
Investigation of VEGF and PDGF signals in vascular formation by 3D culture models using mouse ES cells
... in PDGF B showed immunoreactivities of either Eph B2 (an arterial marker) or Flt4 (a lymphatic ...in PDGF B (Figure 6(b)). Although VEGF had never been added to the culture medium of the PDGF ...
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Apical accumulation of the Drosophila PDGF/VEGF receptor ligands provides a mechanism for triggering localized actin polymerization
... In this study, we identify broad expression of the Drosophila PDGF/VEGF receptor (PVR) in epithelial tissues. We specifically examined possible roles of the PVR pathway in the wing disc epithelium. Two of ...
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PDGF-CC underlies resistance to VEGF-A inhibition and combinatorial targeting of both suppresses pathological angiogenesis more efficiently
... of VEGF-A directly upregulated PDGF-CC and its receptors in multiple cell types in pathological angiogenesis in vitro and in ...of VEGF-A and PDGF-CC suppressed pathological angiogenesis more ...
14
Original Article The expressions of HGF, PDGF, VEGF and AngI in peripheral arterial blood and coronary artery blood of patients with acute coronary syndromes and the relationship with disease severity
... and PDGF are ex- pressed in various organs through the endo- crine pathway ...and PDGF from the coronary artery blood of ACS patients are higher than those from the peripheral arte- rial blood, which was ...
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EPCs enhance angiogenesis in renal regeneration
... Tissue specimens was H&E stained to evaluate MVD. MVD results revealed higher levels of angiogenesis in EPCs group. These results confirmed that EPCs transplantation can promote angiogenesis in damaged kidney and the ...
9
The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian children
... plasma VEGF, PDGF, FGF, and Ang-1 concentrations are associated with an unfavorable outcome in children with severe bacterial infection, the association being independent of confounding factors in the case ...
11
Circulating Angiogenesis Factors in Patients with Non-Hodgkin’s Lymphoma
... As angiogenesis is regulated by the impact of competing influences between inhibitors and activators, balance between positive and negative angiogenic molecules is of great importance [18]. Increasing interest in ...
18
Original Article Targeting the VEGF and PDGF signaling pathway in glioblastoma treatment
... It is already demonstrated the overexpression of PDGF ligands and receptors in human glio- mas tissues [31-34] or GB cell lines [35]. Both the growth factor and its receptors are capable to mediate GB cells ...
13
Rationale for targeting VEGF, FGF, and PDGF for the treatment of NSCLC
... Abstract: Lung cancer remains a leading cause of death globally, with the most frequent type, nonsmall cell lung cancer (NSCLC), having a 5-year survival rate of less than 20%. While platinum-based doublet chemotherapy ...
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Exclusive inhibition of PI3K/Akt/mTOR signaling is not sufficient to prevent PDGF-mediated effects on glycolysis and proliferation in colorectal cancer
... besides VEGF/EGFR-based antibody ...of PDGF in colorectal cancer. PDGF was expressed intensively in early and even more intensively in late stage primary ...Like VEGF, PDGF enhanced ...
19
Metabolic syndrome and the skin: a more than superficial association. Reviewing the association between skin diseases and metabolic syndrome and a clinical decision algorithm for high risk patients
... α; VEGF: vascular endothelial growth factor; PDGF‑BB: BB isoform of the platelet derived 5 growth factor; GM‑CSF: granulocyte‑ macrophage colony‑stimulating factor; RANTES: regulated on activation, normal T ...
11
The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy
... Stromal cells, on the other hand, facilitate tumor growth and tumor dissemination mostly by regulating cancer cell adhesion and contributing to cell proliferation and survival. It was shown that hypoxia induces stromal ...
10
Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential
... that PDGF enhanced EV release and their angiogenic ...EVs. PDGF, but not VEGF or FGF, was found to enhance EV secretion and to change their content of pro- angiogenic mediators resulting in an ...
12
Expressions of Growth Factors in Autologous Derived Platelet-Rich Plasma and Platelet-Poor Plasma; Implication for Tissue Reparation and Wound Healing
... 0.180ng/ml with a 4 fold increase, TGF-beta1; 28.384 ± 14.63ng/ml with a 27 fold increase. No significant was found in IGF in this study, IGF in PRP was 115.1± 32.54pg/ml: 106.1± 102.2 pg/ml in PPP. The level of platelet ...
7
Growth factors in periodontal regeneration: A review
... activator. PDGF up- regulates the expression of angiogenic molecule like vascular endothelial growth factor (VEGF) and hepatocyte growth factor, and also the proinflammatory cytokine interleukin-6, thereby ...
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