VEGF receptor
FGF dependent regulation of VEGF receptor 2 expression in mice
... to VEGF and thus regulates VEGF function, we used a cytoplasmic trun- cated form of FGF receptor 1 (FGFR1) able to heterodimerize with all FGFRs as a dominant-negative construct (FGFR1DN), thereby ...
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The P2Y2 Receptor Interacts with VE Cadherin and VEGF Receptor 2 to Regulate Rac1 Activity in Endothelial Cells
... for VEGF-induced serine phosphorylation and β -arrestin-dependent endocytosis of VE-cadherin ...whereas VEGF was reported to induce rapid internalization of VE-cadherin within minutes [49], suggesting that ...
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Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor 2, and angiopoietin 2
... coordinated VEGF/Ang-2 activity are an increase in host vessel permeability, loss of blood-brain-barrier func- tion in cerebral vessels, microvascular dilation, and sprout ...factor VEGF (41). Consequently, ...
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Expression and characterization of a soluble VEGF receptor 2 protein
... receptors, VEGF and VEGFR-neutralizing ...both VEGF and VEGFRs such as small molecules or antisense oligodeoxynucleotides that inhibit VEGFR signal transduction have also been ...endogenous VEGF, ...
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Imaging VEGF receptor expression to identify accelerated atherosclerosis
... enhanced VEGF/VEGFR signaling plays an important role in three critical processes leading to plaque vulnerability: stimulation of angiogenesis in plaque, recruitment of mo- nocytes into plaque, and increasing ...
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Targeted treatment for advanced soft tissue sarcoma: profile of pazopanib
... the VEGF and PDGF receptor kinases ...of VEGF receptor 2, ie, a quinazoline and a ...for VEGF receptor 2 was not available at the time of the study, binding models were developed ...
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Differential apicobasal VEGF signaling at vascular blood neural barriers
... S1). VEGF receptor distribution was also interrogated in vivo: the luminal side of the mouse vasculature was exposed for 5 min to anti-VEGFR1 or -R2 antibodies by cardiac ...of VEGF receptors in ...
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Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone
... the VEGF signals were mainly mediated via Flk-1, the type-II VEGF receptor ...most VEGF signals were transmitted via Flt-1, as was previously shown ...of VEGF on monocytes migra- tion, ...
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Signaling pathways in the development of infantile hemangioma
... of VEGF-A expression ...elevated VEGF receptor expression in the newly formed and therefore immature vascular plexus at the angiogenic front ...of VEGF signaling in HemECs, Notch components ...
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Selective stimulation of VEGFR 1 prevents oxygen induced retinal vascular degeneration in retinopathy of prematurity
... two VEGF-A receptors, VEGF receptor–1 (VEGFR-1, also known as Flt-1) and VEGF receptor–2 (VEGFR-2, also known as ...two VEGF-A receptors differed markedly during normal retinal ...
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Resveratrol ameliorates high-glucose-induced hyperpermeability mediated by caveolae via VEGF/KDR pathway
... of VEGF was found in the progression of nephritic and ophthalmic complications in diabetes (Kim et ...by VEGF in diabetic condition is not clear; however, there are evidences indi- cating that caveolae was ...
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Differential apicobasal VEGF signaling at vascular blood-neural barriers
... S1). VEGF receptor distribution was also interrogated in vivo: the luminal side of the mouse vasculature was exposed for 5 min to anti-VEGFR1 or -R2 antibodies by cardiac ...of VEGF receptors in ...
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Vascular endothelial growth factor regulates osteoblast survival – evidence for an autocrine feedback mechanism
... of VEGF receptors, flt-1 and/or KDR on numerous other cell types, including osteoblasts ...the VEGF family. This protein is known to bind to Flt-1 receptor with high affinity but fails to bind the ...
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Comparison of the diagnostic values of circulating steroid hormones, VEGF A, PIGF, and ADAM12 in women with ectopic pregnancy
... circulating VEGF isoforms to understand the mechanisms by which their synthesis is regulated and to understand their bio- logical functions during Fallopian tubal ...of VEGF-A and PIGF. In the human ...
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The association of angiogenic factors and chronic kidney disease
... suggested VEGF expression was reduced in the biop- sied kidney tissue from patients with diabetic nephropathy ...soluble VEGF receptor-1 (sVEGFR-1) and reduced VEGFR-2 were associated with mortality ...
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VEGF 936C>T is predictive of threshold retinopathy of prematurity in Japanese infants with a 30-week gestational age or less
... the VEGF mRNA 3’-UTR, recognition of the specific mRNA sequence and secondary structure by these regulatory factors may be disrupted by the ...that VEGF 936 T allele was responsible for hindering and ...
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Granulocyte-Colony Stimulating Factor Receptor, Tissue Factor, and VEGF-R Bound VEGF in Human Breast Cancer In Loco
... with minimal background staining. Controls con- sisted of omission of the primary antibodies from the procedure. The results of staining the breast cancer tissues were compared with respective healthy tissues and were ...
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The relevance of cell type- and tumor zone-specific VEGFR-2 activation in locally advanced colon cancer
... Two observations of vascular VEGFR-2 expression in distant metastatic CC are of importance. In a relatively large number of carcinomas with distant metastasis VEGFR-2 positivity was observed consistently in large vessels ...
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Transferrin receptor-1 and VEGF are prognostic factors for osteosarcoma
... and VEGF are prognostic factors for OS patients Table 4 showed the results of multivariate Cox hazard analysis of univariate factors listed in Table ...and VEGF expression were identified as independent ...
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Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model
... A2B receptor plays a pivotal role in promoting tumor ...A2B receptor agonist, showed enhanced tumor VEGF-A expression and vessel ...A2B-induced VEGF production. However, A2B receptor ...
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