VEGF signaling
Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
... including VEGF. Western blot analyses of the expres- sion of VEGF, HIF-1 α , and PI3K (p85) were ..., VEGF, and PI3K in ...modify VEGF–VEGF receptor signaling, the findings of ...
15
Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis
... Dnm2, VEGF receptor endocytosis is impaired and VEGF signaling is ...augmented VEGF signaling, VEGF-induced cell migration and tubular morphogenesis is impaired, implying that ...
8
Apatinib inhibits VEGF signaling and promotes apoptosis in intrahepatic cholangiocarcinoma
... effect, VEGF may regulate tumor growth through direct binding to VEGFRs present on cancer cells themselves ...autocrine VEGF signaling is also reported in normal rat cholangiocytes [22], its role in ...
10
Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling
... and signaling (30), raising the possibility that epsin deficien- cy results in abnormal VEGFR2 signaling and endothelial cellular responses required for ...to VEGF should be enhanced by epsin ...to ...
16
The neural tube patterns vessels developmentally using the VEGF signaling pathway
... the VEGF signaling pathway is required for multiple steps in vascular development, including ...of VEGF signaling, the population of cells that respond to patterning signals is not ...for ...
11
Localized VEGF signaling from ectoderm to mesenchyme cells controls morphogenesis of the sea urchin embryo skeleton
... for VEGF, as in other ...of VEGF and guide their migration (Gerhardt et ...embryo, VEGF signaling might stabilize PMC filopodia that randomly explore the ectoderm wall and contact the ...
10
Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis
... angiogenesis. VEGF-A is the key growth factor involved in the regulation of vascular development and vasculature ...of VEGF-A are primarily mediated through high-affinity binding to VEGF receptor 2 ...
17
Comparative analysis of various modularization algorithms and species specific study of VEGF signaling pathways
... took VEGF signaling path- way, which is responsible for angiogenesis for this kind of modularized ...human VEGF signaling ...of VEGF signaling pathway over these ...
11
A new chemical inhibitor of angiogenesis and tumorigenesis that targets the VEGF signaling pathway upstream of Ras
... CJ7 cells (1000 cells/well; 12-well plates) were allowed to differentiate in collagen gels in Iscove’s medium containing Glutamax (Iscove’s modified Dulbecco’s medium; Invitrogen) supplemented with 1.2 mg/mL collagen I ...
30
Evaluation of the Response of Intracranial Xenografts to VEGF Signaling Inhibition Using Multiparametric MRI.
... observed herein therefore suggests that cediranib is targeting permeable neovasculature in the intracranial MDA-MB-231 LM2-4 tumors. Indeed, previous studies of anti-VEGF therapeutics have shown that the reduction ...
40
Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish
... Hedgehog signalling plays a crucial role in inducing arterial fate in the zebrafish embryo. Elegant experiments by Lawson et al. (2002) revealed a hierarchy of signalling, initiated by Hh and leading, via the induction ...
21
Differential apicobasal VEGF signaling at vascular blood-neural barriers
... S1). VEGF receptor distribution was also interrogated in vivo: the luminal side of the mouse vasculature was exposed for 5 min to anti-VEGFR1 or -R2 antibodies by cardiac ...of VEGF receptors in ganglion ...
13
VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG
... All animal experimentation conformed to the APS’s Guiding Principles in the Care and Use of Animals and was approved by the OUHSC Animal Care & Use Com- mittee (protocol #08-105). Urinary bladders isolated from TRPV1 ...
20
Differential apicobasal VEGF signaling at vascular blood neural barriers
... and VEGF-E led to rapid p38 activation, but only when growth factors were administered from the tissue side through a cranial window (Figure ...of VEGF-A or PlGF-1 but not VEGF-E led to strong Akt ...
12
SNPs, linkage disequilibrium, and chronic mountain sickness in Tibetan Chinese
... oxygen signaling pathway, the endothetal Per- Arnt-Sim domain protein 1 (EPAS1) and the egl nine homolog 1 (ENGL1) (rs480902) SNPs were included in the ...(VEGF) signaling pathway included are the ...
8
SOX5 induces lung adenocarcinoma angiogenesis by inducing the expression of VEGF through STAT3 signaling
... in VEGF at both mRNA and protein levels in ...of VEGF expression. Then we further analyzed the correlation between VEGF and SOX5 in 90 LAC ...and VEGF in LAC was positively correlated (r = ...
9
VEGF/VEGFR2 blockade does not cause retinal atrophy in AMD-relevant models
... of VEGF or VEGFR2 suppression on photoreceptor function or survival in mice with inherited retinal degen- ...VEGFR signaling in the survival of photoreceptors that are under ...of VEGF provide any ...
15
A Slit/miR 218/Robo regulatory loop is required during heart tube formation in zebrafish
... Slit/Robo signaling is required to downregulate E- cadherin cell-surface localization during lumenization of the heart tube (Medioni et ...that Vegf is also required for migration of the heart fields to the ...
11
A network pharmacology-based strategy deciphers the underlying molecular mechanisms of Qixuehe Capsule in the treatment of menstrual disorders
... and VEGF signaling path- ways; In the TCM theory, the main biological functions of the liver in human body is to regulate the circulation of “qi”, and the stagnation of “qi” often leads to the occur- rence ...
11
Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy
... targeting VEGF signaling are effective in treating age-related macular degenera- tion, but thus far, their utility in cancer has been limited to pro- longing disease-free survival in patients with a few ...
12