VEGF, VEGFR-2
EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF
... the VEGFR-2 tyrosine kinase receptor in both endothelial and tumor cells, as it directly interacts with it and regulates its activation by its VEGF ligand, signalling and functional consequences both ...
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Expressions of VEGF-A and VEGFR-2 in placentae from GDM pregnancies
... of VEGF-A and VEGFR-2 in the placental samples obtained from the GDM and control pregnancies were quantified in an ABI Prism 7700 (Perkin-Elmer/Applied Biosystems) using prevalidated Assays on Demand ...
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<p>Rapamycin suppresses angiogenesis and lymphangiogenesis in melanoma by downregulating VEGF-A/VEGFR-2 and VEGF-C/VEGFR-3 expression</p>
... Rapamycin and its derivatives were reported to have antitumor properties. The mechanism included inhibiting the growth of tumor and anti-angiogenesis. 14 – 16 In vivo or in vitro studies showed dose-dependent effects of ...
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Expression of VEGF-C and activation of its receptors VEGFR-2 and VEGFR-3 in trophoblast
... VEGF: vascular endothelial growth factor; VEGF-C: vascular endothelial growth factor-C; VEGFR-l: vascular endothelial growth factor receptor-l (Fit-I); VEGFR-2: vascular e[r] ...
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The relevance of cell type- and tumor zone-specific VEGFR-2 activation in locally advanced colon cancer
... the VEGFR-2 – activating pathway in colon cancer (CC) tumor ...the VEGFR-1 – activating pathway in CC, we have shown that VEGF is abundantly expressed by tumor cells as well as micro- and ...
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Original Article Changes in nerve fibers and microvessel density in residual spleen after subtotal splenectomy due to portal hypertension
... of VEGF, VEGFR-2, and CD34 showed a significantly higher MVD and positive expression ratio of VEGF, VEGFR-2, and CD34 was observed in the splenomegaly group com- pared with the ...
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Fatty Acid Synthase Mediates the Epithelial-Mesenchymal Transition of Breast Cancer Cells
... and VEGF/VEGFR-2 in both in vitro and in vivo models ( nude mouse tumor ...L-FABP, VEGF, and ...with VEGF on the cell membrane and with L-FABP within MCF-7-MEK5 ...and ...
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Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy
... with VEGF or VEGFR-2 blocking antibodies similarly reduced tumor angiogenesis and growth; however, no additive inhibi- tion was obtained by targeting both Tie1 and ...by VEGF, Angpt, and Notch ...
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The effect of Centella asiatica to the vascular endothelial growth factor and vascular endothelial growth factor receptor-2 on the rotenone induced zebrafish larvae (Danio rerio) stunting model
... the VEGF (Vascular Endothelial Growth Factor) that will attached with its receptor called the VEGFR-2 (Vascular Endothelial Growth Factor Receptor - ...The VEGFR-2 has a bigger role ...
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Heterodimerisation between VEGFR-1 and VEGFR-2 and not the homodimers of VEGFR-1 inhibit VEGFR-2 activity
... prove VEGF-E:PlGF-1 acts through PI3K to inhibit VEGFR-2 activity, we investigated whether inhibition of PI3K could abrogate the VEGF-E:PlGF-1 mediated inhibition of VEGFR-2 ...
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Chronic obstructive pulmonary disease and lung cancer: underlying pathophysiology and new therapeutic modalities
... via VEGF [168]. Interestingly, VEGF is synthesised in high amounts by distally derived lung fibroblasts and induced by both prostacyclin and ...synthesised VEGF acted in an autocrine fashion by ...
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The association of angiogenic factors and chronic kidney disease
... of VEGF-A ...Plasma VEGF-A, sVEGFR-1, VEGFR-2, and angiopoietin-1 were measured using a sand- wich immunoassay on a Meso Scale Discovery Instrument (Meso Scale Diagnostics, ...for ...
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Selective stimulation of VEGFR 1 prevents oxygen induced retinal vascular degeneration in retinopathy of prematurity
... two VEGF-A receptors, VEGF receptor–1 (VEGFR-1, also known as Flt-1) and VEGF receptor–2 (VEGFR-2, also known as ...two VEGF-A receptors differed markedly during ...
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Detection of Serum Vascular Endothelial Growth Factors (VEGF) And Soluble Vascular Endothelial Growth Factors (sVEGF / sflt-1) of Pregnancy Induced Hypertension Mothers (PIH) With pathological changes of Placenta In a Tertiary Care Hospital of West Bengal.
... growth factor (VEGF) and related ligands include VEGFR1 (Flt-1), VEGFR-2 (KDR/ Flk-1), and VEGFR-3 (Flt-4).The interaction may facilitate the presentation and binding of VEGF to its ...
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Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis
... on VEGF responses remains ...promotes VEGF-induced human and murine EC proliferation and ...blunted VEGF responses in vivo and attenuated VEGF-induced VEGFR-2 signaling without ...
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Genetic variants of VEGFR-1 gene promoter in acute myocardial infarction
... to VEGFR-1 and VEGFR-2 selectively [38–43]. VEGFR-1 has a primary role in embryonic ...of VEGFR-1 intracellular kinase domain showed correct development of blood vessels ...While ...
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In Vivo Correlation of Tumor Blood Volume and Permeability with Histologic and Molecular Angiogenic Markers in Gliomas
... tumor permeability could be a better predictor of immature or leaky blood vessels and a more aggressive angiogenic pheno- type that has a higher VEGF expression, as shown by correla- tion of VEGFR-2 ...
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Avian leukosis virus subgroup J induces VEGF expression via NF-κB/PI3K-dependent IL-6 production
... IL-6-induced VEGF-A and VEGFR-2 expression, VECs were transfected with the IL-6 gene expression vector or control vector for 48 ...or VEGFR-2 (forward 5′-TAA GGC ATC CAA CCA GAC AAG-3′, ...
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The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis
... Myography. All experiments were performed according to the Animals Scientific Procedures Act 1986 (U.K. Home Office) 59 . Briefly, adult male Wistar rats (250–400 g; Charles River, Margate, UK) were killed by cervical ...
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Exercise-induced expression of angiogenic growth factors in skeletal muscle and in capillaries of healthy and diabetic mice
... The strong correlations found between the proangiogenic factors revealed that mice showing high expression of ang- iogenic growth factors VEGF-A and VEGF-B, also showed high expression of their receptors, ...
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