VEGFR-2(Flk-1)
Higher expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) and metalloproteinase-9 (MMP-9) in a rat model of peritoneal endometriosis is similar to cancer diseases
... at 1:200 dilution, monoclonal antibody against a -smooth muscle actin (a-SMA) M0851 (DakoCytomation, Car- pinteria, CA) at 1:100 dilution, monoclonal antibody against VEGF SC-7269 (Santa Cruz Biotechnology, ...
9
<p>Rapamycin suppresses angiogenesis and lymphangiogenesis in melanoma by downregulating VEGF-A/VEGFR-2 and VEGF-C/VEGFR-3 expression</p>
... Rapamycin and its derivatives were reported to have antitumor properties. The mechanism included inhibiting the growth of tumor and anti-angiogenesis. 14 – 16 In vivo or in vitro studies showed dose-dependent effects of ...
12
Blockade of VEGFR 1 and VEGFR 2 Enhances Paclitaxel Sensitivity in Gastric Cancer Cells
... of VEGFR-1 and VEGFR-2 decreases resistance to pacli- taxel in AGS ...*p<0.05. VEGFR, vascular endothelial growth factor receptor; SEM, standard error of the ...
7
Expressions of VEGF-A and VEGFR-2 in placentae from GDM pregnancies
... stimulation of fetal metabolism. Lower fetal oxygen content associated by higher lactate concentrations may certainly reflect enhanced fetal metabolism as a result of hyperglycaemia and hyperinsulinemia [24]. ...
9
Expression of VEGF-C and activation of its receptors VEGFR-2 and VEGFR-3 in trophoblast
... VEGF: vascular endothelial growth factor; VEGF-C: vascular endothelial growth factor-C; VEGFR-l: vascular endothelial growth factor receptor-l (Fit-I); VEGFR-2: vascular e[r] ...
17
The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis
... human VEGFR-1, thus PAER-2 are the parent cells of PAER-1:R-2 ...total VEGFR-2, VEGFR-2 levels were found to be lower in PAER-2 cells compared with ...
12
Effects of Interferon Alpha 2b on VEGFR 2, VEGFA, MAPK 1 and ERK 1 Gene Expression in Corneal Neovascularization Models
... for VEGFR-2, VEGFA , MAPK-1 and ERK were used for analysis using SYBR Green on a LightCycler 480 real-time PCR System (Roche Diagnostics, Indianapolis, IN) ...
9
Carbohydrate binding protein CLEC14A regulates VEGFR 2– and VEGFR 3–dependent signals during angiogenesis and lymphangiogenesis
... neuropilin 1, which interact with VEGFR-2 or act as coreceptors to enhance VEGFR-2 affinity for VEGF-A ...of VEGFR-2 was increased by Clec14a silencing in the absence or ...
16
Heterodimerisation between VEGFR-1 and VEGFR-2 and not the homodimers of VEGFR-1 inhibit VEGFR-2 activity
... regulates VEGFR-2 ...represents VEGFR-2 receptor and black bar represents VEGFR-1 ...against VEGFR-1 (siR-1) and subsequently stimulated with VEGF-A (20 ...
42
Detection of Serum Vascular Endothelial Growth Factors (VEGF) And Soluble Vascular Endothelial Growth Factors (sVEGF / sflt-1) of Pregnancy Induced Hypertension Mothers (PIH) With pathological changes of Placenta In a Tertiary Care Hospital of West Bengal.
... growth factor (VEGF) and related ligands include VEGFR1 (Flt-1), VEGFR-2 (KDR/ Flk-1), and VEGFR-3 (Flt-4).The interaction may facilitate the presentation and binding of VEGF to ...
10
Vascular endothelial growth factor receptor 2–mediated angiogenesis is essential for gonadotropin dependent follicle development
... the VEGFR-2 pathway for gonadotropin-dependent follicle development we chose a model, the prepuberally hypophysectomized (HX) mouse, in which active feedback is ...of VEGFR-2–neutralizing ...
12
Thorsteinsdottir, Jun (2011): Effekte einer anti-VEGF-A-Therapie (Bevacizumab) auf humane cerebrale Endothelzellen sowie Tumor- und Endothelzellen in humanen Gliomen. Dissertation, LMU München: Medizinische Fakultät
... Im Glioblastom scheint VEGF-A eine tragende Rolle zu spielen, da es im Vergleich zu Normalhirngewebe 50fach überexprimiert ist (Plate et al.). In einer Reihe von Tumorentitäten, darunter v.a. in Gliomen, korreliert die ...
102
Percutaneous coronary intervention causes a rapid but transient mobilisation of CD34+CD45− cells
... + VEGFR-2 + cells within the fi rst few hours of coronary ...+ VEGFR-2 + CD45 − and CD133 + VEGFR-2 + CD45 − cells prior to revascularisation identi fi ed patients more likely to ...
10
Angiogenic and FLT3 Receptors Expression in Acute Lymphoblastic Leukemia in Pediatric Age Group
... expressing VEGFR-1 and VEGFR-2 (r = ...expressing VEGFR-1, and those expressing VEGFR-2 (r = ...FLT3, VEGFR-1 and -2, with blasts % expressing ...
16
Glioblastoma vasculogenic mimicry: signaling pathways progression and potential anti-angiogenesis targets
... both VEGFR-2 and VEGF are co-expressed during ...[18,40]. VEGFR-2, a receptor tyrosine kinase, is the earliest dif- ferentiation marker for ...[29]. VEGFR-2 has been reported to ...
10
Synthesis, characterization and molecular docking studies of anilinoquinazoline derivatives
... The co-ordinates of VEGFR-2 and EGFR were obtained from the Brookhaven Protein Data Bank (PDB), whose PDB IDs are 4ASE (Yun et al., 2007) and 2ITY (Raghavendra et al., 2007) respectively. Ligands were drawn ...
9
Exercise-induced expression of angiogenic growth factors in skeletal muscle and in capillaries of healthy and diabetic mice
... (Mm00442102_m1), VEGFR-1 (Mm00438980_m1), VEGFR-2 (Mm00440099_m1), TSP-1 (Mm00449022_m1) and Cyr61 (Mm00487498_m1) were designed and synthesized by Applied ...Bulletin 2 (Applied ...
10
Expression and localization of mRNA for the VEGF system and FP receptor in porcine corpora lutea.
... The corpus luteum (CL), a transient ovarian endocrine gland developed from the ovulated follicle, is a source of the steroid hormone progesterone, which is essential for the establishment and maintenance of pregnancy. In ...
299
The association of angiogenic factors and chronic kidney disease
... sVEGFR-1, VEGFR-2, and angiopoietin-1 were measured using a sand- wich immunoassay on a Meso Scale Discovery Instrument (Meso Scale Diagnostics, ...for VEGFR-2, 10.13% for ...
8
Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis
... VEGF-induced VEGFR-2 signaling without altering VEGF receptor or neuro- pilin ...with VEGFR-2 and regulates its complex formation with negative regulators of VEGF signaling, protein tyrosine ...
17