VEGFR-2/(KDR)
Autocrine stimulation of VEGFR 2 activates human leukemic cell growth and migration
... the VEGFR-2 signaling pathway. VEGFR-2 (KDR, human homologue; Flk-1, murine homologue) binds to several soluble factors including VEGF, which exerts proliferative and migratory effects ...
12
The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis
... membrane-bound VEGFR-1 homomeric receptor negatively regulates VEGFR-2-mediated endothelial cell prolif- eration 14–17 and tumour growth 18 .... VEGFR-1 can transactivate VEGFR-2 ...
12
Blockade of VEGFR 1 and VEGFR 2 Enhances Paclitaxel Sensitivity in Gastric Cancer Cells
... of VEGFR-1 and VEGFR-2 decreases resistance to pacli- taxel in AGS ...*p<0.05. VEGFR, vascular endothelial growth factor receptor; SEM, standard error of the ...
7
receptor and VEGFR-2 polymorphisms identifies a favorable prognostic profile in prostate cancer patients
... the VEGFR-2 SNPs and susceptibility or prognosis in several different types of cancers, such as renal cell carcinoma, colorectal cancer, hepatocellular carcinoma and glioblastoma, has been studied ...in ...
12
EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF
... receptor VEGFR-2 in both endothelial cells and tumor cells, in a mechanism mediated by HIF-2 alpha [9] thus increasing respectively angiogenesis and ...
15
Carbohydrate binding protein CLEC14A regulates VEGFR 2– and VEGFR 3–dependent signals during angiogenesis and lymphangiogenesis
... higher VEGFR-2 expression in the vessels of both tumor types from CLEC14A-KO mice, consistent with our data from embryos and retinae (Supplemental Figure 17, ...attenuates VEGFR-3 expression, ...
16
Expressions of VEGF-A and VEGFR-2 in placentae from GDM pregnancies
... and VEGFR-2 in the placental samples obtained from the GDM and control pregnancies were quantified in an ABI Prism 7700 (Perkin-Elmer/Applied Biosystems) using prevalidated Assays on Demand (consisting of a ...
9
<p>Rapamycin suppresses angiogenesis and lymphangiogenesis in melanoma by downregulating VEGF-A/VEGFR-2 and VEGF-C/VEGFR-3 expression</p>
... Rapamycin and its derivatives were reported to have antitumor properties. The mechanism included inhibiting the growth of tumor and anti-angiogenesis. 14 – 16 In vivo or in vitro studies showed dose-dependent effects of ...
12
Expression of VEGF-C and activation of its receptors VEGFR-2 and VEGFR-3 in trophoblast
... VEGF: vascular endothelial growth factor; VEGF-C: vascular endothelial growth factor-C; VEGFR-l: vascular endothelial growth factor receptor-l (Fit-I); VEGFR-2: vascular e[r] ...
17
The relevance of cell type- and tumor zone-specific VEGFR-2 activation in locally advanced colon cancer
... More than ten years ago targeted therapy was heralded as the beginning of a new era in anti-cancer therapy. The goal of targeted therapy is to interfere with specific molecules in the tumor to block its growth and spread ...
13
Heterodimerisation between VEGFR-1 and VEGFR-2 and not the homodimers of VEGFR-1 inhibit VEGFR-2 activity
... inhibit VEGFR-2 activity, we investigated whether inhibition of PI3K could abrogate the VEGF-E:PlGF-1 mediated inhibition of VEGFR-2 biological activity in endothelial ...
42
Sorafenib Acts through VEGFR 2 Inhibition in a Metastatic Clear Cell Sarcoma of the Kidney
... Double fluorescent immunostainings were performed using the following primary antibodies: a rabbit anti- CD34 antibody (polyclonal human, Sigma-ald, Germany) coupled with donkey anti-rabbit IgG H&L Alexa Fluor 555 ...
8
Exercise-induced expression of angiogenic growth factors in skeletal muscle and in capillaries of healthy and diabetic mice
... The strong correlations found between the proangiogenic factors revealed that mice showing high expression of ang- iogenic growth factors VEGF-A and VEGF-B, also showed high expression of their receptors, especially ...
10
Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR 3 expression
... of VEGFR-2 and VEGFR-3 in HUVEC/X and HUVEC/N1IC cultured on type I collagen for 7 ...(B) VEGFR-2 and VEGFR-3 FACS of HUVEC/X and ...
15
The Effect of Turmeric Decoctum to the Angiogenic Molecules Expression on Chicken Embryo
... Turmeric (Curcuma longa) is widely used as herbal medicine, not exception by pregnant women. Turmeric consumption by expec - tant mothers requires standard dose, because of its antiangiogenic effect could be harmful on ...
5
Percutaneous coronary intervention causes a rapid but transient mobilisation of CD34+CD45− cells
... + VEGFR-2 + and CD34 + VEGFR-2 + CD133 + ), and haematopoietic CD45 + subpopulations including angio- genic monocytes were both unaffected by discrete vascu- lar injury up to 1 week following ...
10
The association of angiogenic factors and chronic kidney disease
... sVEGFR-1, VEGFR-2, and angiopoietin-1 were measured using a sand- wich immunoassay on a Meso Scale Discovery Instrument (Meso Scale Diagnostics, ...for VEGFR-2, ...
8
Expression and localization of mRNA for the VEGF system and FP receptor in porcine corpora lutea.
... The corpus luteum (CL), a transient ovarian endocrine gland developed from the ovulated follicle, is a source of the steroid hormone progesterone, which is essential for the establishment and maintenance of pregnancy. In ...
299
Angiogenic and FLT3 Receptors Expression in Acute Lymphoblastic Leukemia in Pediatric Age Group
... both VEGFR-1 and VEGFR-2 (p = ...that, VEGFR-1 signaling only was involved in precursor B cells mobility from bone marrow to spleen, whereas VEGFR-2 was more involved in cell ...
16
Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis
... VEGF-induced VEGFR-2 signaling without altering VEGF receptor or neuro- pilin ...with VEGFR-2 and regulates its complex formation with negative regulators of VEGF signaling, protein tyrosine ...
17