VEGFR-3
Inhibition of Lymphangiogenesis of Endothelial Progenitor Cells with VEGFR-3 siRNA Delivered with PEI-alginate Nanoparticles
... Determination of siRNA loading efficiency VEGFR-3 siRNAs (Table 1) were designed and synthetized by GenePharma (Shanghai, China). The siRNA (1 μg) was dropped to PEI-alginate nanoparti- cle solution at ...
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Expression of VEGFR-3 in intrahepatic cholangiocarcinoma correlates with unfavorable prognosis through lymphangiogenesis
... Figure 3. Positive expression of VEGFR-3 correlates with tumor-associated lymphangiogenesis in ...with VEGFR-3 positive tumors had significantly higher proportion of MLVD (U-test, ...
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The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth
... receptor 3 (VEGFR-3 or ...with VEGFR-3 and provides important survival signals for breast cancer cells ...[24]. VEGFR-3 belongs to the VEGFR family of receptor ...
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Original Article Gecko ethanol extract inhibits lymph angiogenesis through the VEGF-C/VEGFR-3 pathway in vitro and in vivo
... include VEGFR-3 [23, 24], lymphatic endothelial hyaluronic acid receptor-1 (LYVE-1) [25], mucin in glomerular mesangial cells (podoplanin) [26, 27], Prox-1 [28] and antibodies directed against M2A (D2- 40) ...
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The Schlemm’s canal is a VEGF C/VEGFR 3–responsive lymphatic like vessel
... Video 3, and Supplemental Figure 4, ...weak VEGFR-3 expres- sion was detected, and the canal had undergone further lumi- nalization, as fragments of it were detected in the H&E-stained sections ...
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Slit2N and Robo4 regulate lymphangiogenesis through the VEGF-C/VEGFR-3 pathway
... both VEGFR-2 and VEGFR-3 can trigger downstream signaling through the MAP kinases ERK1/2 and PI3K/Akt in vascular endothelial cells ...modulating VEGFR-3 presentation levels on the cell ...
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<p>Rapamycin suppresses angiogenesis and lymphangiogenesis in melanoma by downregulating VEGF-A/VEGFR-2 and VEGF-C/VEGFR-3 expression</p>
... inhibited lymphatic endothelial cell tube formation via down-regulating VEGFR-3 expression. 10 In 2015, Chen demonstrated that lymphangiogenesis in gastric cancer was regulated through the ...
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The Expression of VEGF C and It’s Receptor VEGFR 3 Correlates with Lymph Node Metastasis in Gastric Cancer
... of VEGFR-3 is about ...and VEGFR-3 is closely related to tumor lymph node ...and VEGFR-3 are increased with the growth of clinical stages and the positive ex- pression rate of ...
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Targeting VEGFR-3/-2 signaling pathways with AD0157: a potential strategy against tumor-associated lymphangiogenesis and lymphatic metastases
... In clinical practice, special attention is paid to the regional LNs as the main players in the metastatic dissem- ination [7]. Thus, LN status (presence or absence of tumor cells) is used as a potential diagnostic marker ...
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Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR 3 expression
... induces VEGFR-3 expression in vitro in human endothelial cells and in vivo in ...the VEGFR-3 promoter and transacti- vated VEGFR-3 specifically in endothelial ...of ...
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Carbohydrate binding protein CLEC14A regulates VEGFR 2– and VEGFR 3–dependent signals during angiogenesis and lymphangiogenesis
... higher VEGFR-2 expression in the vessels of both tumor types from CLEC14A-KO mice, consistent with our data from embryos and retinae (Supplemental Figure 17, ...Figure 3. CLEC14A deficiency attenuates ...
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Expression of VEGF-C and activation of its receptors VEGFR-2 and VEGFR-3 in trophoblast
... VEGF: vascular endothelial growth factor; VEGF-C: vascular endothelial growth factor-C; VEGFR-l: vascular endothelial growth factor receptor-l (Fit-I); VEGFR-2: vascular e[r] ...
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Quantitative measurement of lymphatic function in mice by noninvasive near-infrared imaging of a peripheral vein
... mice (Figure 4A), with no signal apparent in K14-VEGFR-3 mice (Figure 4B). Quantification of the blood vessel signal (Figure 4C) revealed vastly reduced lymphatic transport of P40D800 in ...
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Original Article High expression of SOX3 in esophageal carcinoma cells affected lymphatic endothelial cell proliferation
... Abstract: Objective: To investigate the relationship between Sox3 upregulation in esophageal carcinoma cells and lymphatic endothelial cell (LEC) proliferation. Method: Esophageal squamous cell carcinoma cells showing ...
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Detection of Serum Vascular Endothelial Growth Factors (VEGF) And Soluble Vascular Endothelial Growth Factors (sVEGF / sflt-1) of Pregnancy Induced Hypertension Mothers (PIH) With pathological changes of Placenta In a Tertiary Care Hospital of West Bengal.
... growth factor (VEGF) and related ligands include VEGFR1 (Flt-1), VEGFR-2 (KDR/ Flk-1), and VEGFR-3 (Flt-4).The interaction may facilitate the presentation and binding of VEGF to its receptor. PlGF is ...
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Angiogenic and FLT3 Receptors Expression in Acute Lymphoblastic Leukemia in Pediatric Age Group
... The VEGFR-1 (Flt-1) is located at chromosome 13q12 and VEGFR-2 (KDR/Flk-1) is located at chromosome 4q11 and both are expressed on vascular endothelial cells, whereas VEGFR-3 is expressed on ...
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Activation of Akt through gp130 Receptor Signaling Is Required for Kaposi's Sarcoma-Associated Herpesvirus-Induced Lymphatic Reprogramming of Endothelial Cells
... reprogramming. VEGFR-1, -2, and -3 are ...in VEGFR-3 induc- ...with 3 g negative-control (lane C) or Prox1 (lane P) siRNA and subsequently harvested at 72 h ...with 3 g of ...
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Original Article The antitumor effect of the novel cancer-specific adenovirus Ad-VEGFR on bladder cancer in vitro and in vivo
... Abstract: Bladder cancer is one of the most common cancers. Approaches that block tumor angiogenesis are a new therapeutic strategy for locally advanced or metastatic BC. VEGF/VEGFR signaling has been obviously ...
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VEGF C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedema
... rabbit VEGFR-3, was 5′- TATG- GTACAAAGATGAGAGGC -3′ (sense) and 5′- ACAGGTATTC- ACATTGCTCCT -3′ ...the VEGFR-3 mRNA, we used the “competimer” quantitative PCR technique (Ambion ...
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Pfeiffer, Sarah Katharina (2017): Biologische Evaluierung radioaktiv markierter Bindeproteine für die nuklearmedizinische Bildgebung der Glioblastom-Vaskulatur. Dissertation, LMU München: Medizinische Fakultät
... Menschen die Gefahr einer Immunreaktion zu minimieren (Vogt, 2004; Kim, 2009). Inzwischen wurden Anticaline auch gegen Peptide und extrazelluläre oder membranständige Proteine selektiert, so dass eine Vielzahl ...
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