ventilator-induced lung injury
RIPK3 mediates pathogenesis of experimental ventilator-induced lung injury
... of ventilator-induced lung injury (VILI) was established when a randomized controlled trial reported that mechanical ventilation (MV) with high tidal volume ...
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Inhaled activated protein C protects mice from ventilator induced lung injury
... whole lung lysates following ventilation with tidal volume of 25 ...in lung tissue occurs rapidly, within 30 minutes and increases after 60 minutes of injurious ...in lung homogenate following ...
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Dual effects of human neutrophil peptides in a mouse model of pneumonia and ventilator-induced lung injury
... Bacterial pneumonia is a leading cause of acute respiratory distress syndrome (ARDS) and sepsis contributing to high mortality in the intensive care unit (ICU) [1–3]. During the onset of pneumonia neutrophils are ...
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Bench to bedside review: Damage associated molecular patterns in the onset of ventilator induced lung injury
... initiate lung damage and worsen pre-existing lung damage, termed ventilator-induced lung injury (VILI) in animals and ventilator-associated lung injury in ...
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Lung stress, strain, and energy load: engineering concepts to understand the mechanism of ventilator-induced lung injury (VILI)
... the lung and prevent edema formation ...this ventilator-induced lung injury (VILI) are alveolar overdistension (volutrauma), alveolar instability leading to alveolar collapse and ...
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Original Article Celastrol attenuates ventilator induced lung injury in mouse through inhibition of MAPK pathway
... on ventilator induced lung injury ...increased lung MPO and MDA activity, TNF-α, IL-1β and IL-6, but dramatically reduced SOD and IL-10 (all ...related lung fibrosis to attenuate ...
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Ventilator-induced lung injury: historical perspectives and clinical implications
... The prognosis of the acute respiratory distress syndrome (ARDS) has improved dramatically within the past dec- ades, with in-hospital mortality rates ranging from 90% in the seventies [1] to approximately 30% in a recent ...
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Activation of c-Src tyrosine kinase mediated the degradation of occludin in ventilator-induced lung injury
... Ventilator-induced lung injury (VILI) is a common iatro- genic clinical phenomenon in intensive care and anesthesia ...of lung injury ...
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Mechanical ventilation modulates TLR4 and IRAK-3 in a non-infectious, ventilator-induced lung injury model
... in lung homogenates, the goal of the present study was to determine the contribution of MV in the regulation of TLR and IRAK-3 signaling in a non-infectious, experimental model of ventilator- induced ...
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Risk factors of ventilator-induced lung injury: mechanical power as surrogate of energy dissipation
... ventilation—namely ventilator-induced lung injury (VILI)—became evident ...additional lung damage—the so-called “lung protective” ventilation ...single ventilator variable ...
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Anti-inflammatory effects of clarithromycin in ventilator-induced lung injury
... aggravate lung injury by a multifactorial mechanism, in which deform- ation of lung tissue triggers a complex biological re- ...the lung have been demonstrated effective to decrease ...
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Protective role of p120-catenin in maintaining the integrity of adherens and tight junctions in ventilator-induced lung injury
... Mechanical ventilation is an indispensable therapy for patients with acute lung injury and acute respiratory distress syndrome. However, irregular mechanical stresses and strains can easily cause airway and ...
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GABA receptor ameliorates ventilator induced lung injury in rats by improving alveolar fluid clearance
... of ventilator-induced lung ...distal lung epithelial cells. Increased apoptosis of distal lung epithelial cells occurs in acute lung injury (ALI) and acute respiratory ...
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Inflammatory and transcriptional roles of poly (ADP ribose) polymerase in ventilator induced lung injury
... of ventilator-induced lung injury The posterior portions of the right lower lobe were sectioned at a thickness of 5 μm, placed on glass slides, and stained with ...of lung injury ...
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Heparin-binding protein in ventilator-induced lung injury
... cause injury to the lungs. The lung injury is caused by not only high pressure and mechanical forces but also by inflammatory processes that are not fully ...the lung injury associated ...
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Close down the lungs and keep them resting to minimize ventilator induced lung injury
... so-called ventilator- induced lung injury (VILI), especially in patients with acute respiratory distress syndrome (ARDS) ...aerated lung tissue as a result of edema and atelectasis, ...
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Genetic and pharmacologic inhibition of Tpl2 kinase is protective in a mouse model of ventilator-induced lung injury
... In this study, we use our established model of aseptic, ‘ one-hit ’ VILI [33], to clarify the role of Tpl2. This ‘one-hit’ model is widely used in studies to investigate the pathogenesis of VILI. Using this model, we ...
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The time-controlled adaptive ventilation protocol: mechanistic approach to reducing ventilator-induced lung injury
... acute lung injury, the method of treating sepsis-induced ARDS, the novel method of assessing alveolar inflation, the method of reducing blood loss associated with cardiopulmonary bypass, minimally ...
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Autologous transplantation of adipose derived stromal cells ameliorates ventilator induced lung injury in rats
... H&E-stained lung sections showed normal lung tissue structures in the sham group (Figure ...HVT induced prominent lesions, such as interlobular septal thickening, interstitial inflammation, ...
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Lung anatomy, energy load, and ventilator-induced lung injury
... of lung expansion, as assessed by computed tomography (CT) scan, the inspiratory volumes applied (tidal volume + PEEP volume), and the dynamic and static energy used to induce VILI in healthy ...healthy ...
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