Vessel Formation
XRASGRP2 is essential for blood vessel formation during Xenopus development
... The XRASGRP2-knockdown embryos showed the edema phenotype, which may be due to circulation problems (data not shown) and inhibition of endothelial gene expression (Fig. 3 C-F). This outcome indicates that XRASGRP2 is ...
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Harmine enhances type H vessel formation and prevents bone loss in ovariectomized mice
... Next, CD31 and Emcn immunofluorescence double staining was performed to verify the effects of harmine on type H blood vessel formation. As shown in Figure 6A-B, OVX mice had a significantly lower proportion ...
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SDF 1 controls the muscle and blood vessel formation of the somite
... ABSTRACT Stromal-cell-derived factor-1 (SDF-1), the only ligand of the chemokine receptor CXCR4, is involved in skeletal muscle development. However, its role in the proliferation, differentiation and migration of somite ...
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Coordinating cell behaviour during blood vessel formation
... cell formation in the immediate neighbours (via lateral ...outgrowing vessel branch sequesters VEGF molecules, thereby creating a corridor of higher VEGF levels perpendicular to the parent ...
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Role of glutamine and interlinked asparagine metabolism in vessel formation
... ECs may additionally rely on ASNS in conditions, when ASNS expression levels are elevated upon glucose or amino acid deprivation, or ER stress or when asparagine levels in the extracellu[r] ...
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Assessment Methods of Angiogenesis and Present Approaches for Its Quantification
... blood vessel formation, an intra-arterial bolus injection of the vasodilator sodium nitroprusside (300µg in 1 ml saline), iodinated contrast media (Isovue-370) is infused intra arterially at a constant rate ...
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An injectable sulfonated reversible thermal gel for therapeutic angiogenesis to protect cardiac function after a myocardial infarction
... The sulfonated reverse thermal gel, SPSHU-PNIPAM, loaded with VEGF was evaluated for therapeutic angiogen- esis to protect cardiac function after myocardial infarction. The electrostatic binding affinity of SPSHU-PNIPAM ...
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ICAM-1-Targeted, Lcn2 siRNA-Encapsulating Liposomes are Potent Anti-angiogenic Agents for Triple Negative Breast Cancer
... The CAM assay was performed as previously reported by us.(24–28) Fertilized chicken embryos (Charles River Laboratories, North Franklin, CT) were cultured in-ova. At developmental day 7, 5 µ L of se- rum-free media (1) ...
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Hypoxia-Mimicking Cobalt-Doped Borosilicate Bioactive Glass Scaffolds with Enhanced Angiogenic and Osteogenic Capacity for Bone Regeneration
... ion release at therapeutically acceptable levels. At the concentrations used, the Co in the scaffolds was not cytotoxic and it notably promoted VEGF protein secretion, HIF-1α expression, ALP expression of osteogenic and ...
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Mesoporous bioactive glass combined with graphene oxide scaffolds for bone repair
... local vessel formation in scaffolds after 12 weeks of implantation, micro-CT imaging was carried ...vascular formation, whereas in the other groups a considerable number of vessels extended along the ...
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Vascular endothelial growth factor (VEGF) regulation of endothelial cell behavior through the Rho family of small GTPases
... blood vessel formation and pericyte binding 54,89 ...which vessel growth is not the primary pathogenesis, but the vessels remodel abnormally by pruning or vessel enlargement, for example in ...
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Large is required for normal astrocyte migration and retinal vasculature development
... membrane formation, leading to vitreoretinal blood vessel formation, persistence of fetal vasculature, and epiretinal membrane formation in mice [3, ...
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Bioprinting in Vascularization Strategies
... simultaneously. First, they optimized the composition of a biological bioink composed of gelatin methacryloyl (Gel-MA) and alginate. Subsequently, they developed a microfluidic printhead for bioprinting this ...
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Analysis of the VEGFr1 (Flt-1) isoforms in vascular development
... stimulates endothelial cell migration, division, and survival (Bernatchez et al., 1999; Gerber et al., 1999; Leung et al., 1989). Gene targeting studies have also shed light on the role of VEGF-A, demonstrated by an ...
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Thrombin related peptide TP508 promoted fracture repair in a mouse high energy fracture model
... blood vessel formation in the crushed mus- cles and fracture gap areas and significantly reduced scar formation in the groups receiving TP508 (regardless the dose) comparing to the saline control ...
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EPHB4 kinase–inactivating mutations cause autosomal dominant lymphatic related hydrops fetalis
... lymphatic vessel remodeling and valve formation during late embryonic and early postnatal development (11, 12), but whether they have an earlier role in lymphatic vessel morphogenesis that could ...
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Thrombogenic Effect of High Dose Aspirin in Rabbits: RELATIONSHIP TO INHIBITION OF VESSEL WALL SYNTHESIS OF PROSTAGLANDIN I2 LIKE ACTIVITY
... inhibited vessel wall PGI 2 -like activity whereas aspirin in a 10-mg/kg dose produced less inhibition, and 200 mg/kg sodium salicylate had no ...2 formation, also significantly augmented thrombus size ...
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Neovascularization: topical effects of streptococcus thermophilus and low level laser therapy in treatment of diabetic wound in rats
... Background: Diabetic wound is a major socioeconomic debilitating problem in this society. Various treatment options are available but still it requires better treatment option. In diabetes mellitus the oxygenation to the ...
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Assessing angiogenic responses induced by primary human prostate stromal cells in a three-dimensional fibrin matrix assay
... of vessel development ...lumen formation, a process requiring a distinct constellation of stimuli, including collagen type I alpha-1 (Col1A1), procollagen C-endopeptidase enhancer 1 (PCOLCE), transforming ...
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Response of the neurovascular unit to brain metastatic breast cancer cells
... the vessel lumen by the tumour cell- induced endothelial plug in 3D (i) and cross-section (ii-v) two-photon microscopy images (day ...plug formation in different optical ...
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