viral clearance
Hepatitis B Virus Nucleocapsid but Not Free Core Antigen Controls Viral Clearance in Mice
... detects viral infection through cel- lular ...identified viral PAMPs are nucleic acids, we have shown that without HBcAg, the intra- cellular viral RNA alone did not result in the viral ...
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Alveolar macrophages support interferon gamma-mediated viral clearance in RSV-infected neonatal mice
... We previously reported that i.n. IFNγ reduces the bur- den of RSV L19 in neonatal mice [23]. We further showed a preponderance of AMs in RSV-infected neo- natal compared to adult airways throughout infection [23]. Based ...
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Interleukin 12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B
... the asymptomatic viremic patients, indicating a Th2 predomi- nance in chronic HBV infection (8, 27). A switch to the Th1 type of response would therefore be beneficial and would promote the cellular immune mechanisms ...
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Interferon Regulatory Factor 3 Attenuates Reovirus Myocarditis and Contributes to Viral Clearance
... Peak viral titers at sites of second- ary replication were equivalent in wild-type and IRF-3-defi- cient ...However, viral titers and virus-induced pathol- ogy at these sites were more substantial in the ...
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APOBEC3-Independent Interferon-Induced Viral Clearance in Hepatitis B Virus Transgenic Mice
... for viral clearance (38, 43), and IFN- ␣ has been the treatment of choice for chronic HBV infection, in spite of its limited efficacy in many patients ...RNA-containing viral cores (27, 44, ...
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Sociodemographic and clinical characteristics of persons who experienced spontaneous hepatitis C viral clearance
... against viral pathogens ...HCV clearance in- cludes the fact that African Americans have weaker HCV specific immunity ...HCV clearance occurred in ...HCV clearance, the association between ...
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Alphavirus-Induced Encephalomyelitis: Antibody-Secreting Cells and Viral Clearance from the Nervous System
... mosquito-borne viral encephalomyelitis in the Americas (7, ...virus clearance more difficult ...that clearance of infectious virus from neurons within 7 to 8 days is mediated by gamma interferon ...
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Induction of Long-Term Memory CD8+ T Cells for Recall of Viral Clearing Responses against Influenza Virus
... of viral clearance seen in Pal2-CTL-TH-immu- nized mice is not affected by the depletion of CD4 T cells prior to viral ...of viral clearing responses was investigated by exam- ining the effect ...
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Kinetics of acute hepatitis B virus infection in humans
... of viral clearance (perhaps by the inhibition of HBV attachment to a hepatocyte receptor or the regulation of intrahepatic DNA levels and viral assembly) could be due to pre-S1 an- ...of viral ...
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Immune-Mediated Protection from Measles Virus-Induced Central Nervous System Disease Is Noncytolytic and Gamma Interferon Dependent
... mediate viral clearance via noncytolytic ...immune clearance has also been shown for Sind- bis virus (2), mouse hepatitis virus (26, 34, 48), and vesicular stomatitis virus ...Noncytolytic ...
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Therapeutic Blockade of Transforming Growth Factor Beta Fails To Promote Clearance of a Persistent Viral Infection
... Persistent viral infections often overburden the immune system and are a major cause of disease in ...fosters viral persistence by severely dampening adaptive immune ...persistent viral in- ...
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Therapeutic Memory T Cells Require Costimulation for Effective Clearance of a Persistent Viral Infection
... therapeutic clearance of the persistent viral ...persistent viral infections in humans, as it suggests that an overly robust and potentially injurious immunotherapeutic regimen can be dampened using ...
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Impaired Toll-Like Receptor 3-Mediated Immune Responses from Macrophages of Patients Chronically Infected with Hepatitis C Virus
... Hepatitis C virus (HCV) is the most common chronic blood-borne infection in the United States, with the majority of patients becoming chronically infected and a subset (20%) progressing to cirrhosis and hepatocellular ...
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Interferon- and Ribavirin in Treating Children and Young Adults With Chronic Hepatitis C After Malignancy
... IFN has been shown to be effective in adult pa- tients with chronic hepatitis C, but sustained re- sponse, defined by persistent viral clearance and nor- malization of the aminotransfera[r] ...
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Association of IL 10, IL 4, and IL 28B gene polymorphisms with spontaneous clearance of hepatitis C virus in a population from Rio de Janeiro
... The impact of the cytokine gene polymorphisms in the pathogenesis of HCV infection has also been investigated [8-14]. Recently, a number of studies have reported that polymorphisms near the gene for IL-28B are strongly ...
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DNA vaccination against persistent viral infection.
... We were interested in determining whether DNA vaccina- tion could induce protective immunity against a disseminated persistent viral infection (6). To address this issue we have used the mouse model of infection ...
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PD L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice
... controlling viral clearance and immunopathological damage during LCMV CL-13 infection, while expression on BM- derived cells controls the priming of T cell ...
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Functional Genomics Reveals an Essential and Specific Role for Stat1 in Protection of the Central Nervous System following Herpes Simplex Virus Corneal Infection
... outcomes: viral clearance without neurological disease ( ⌬ vhs infection of control mice), neurological disease followed by viral clearance ( ⌬ vhs infection of Stat1 ⴚ/ⴚ mice and WT infection ...
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Identification of Differentially Activated Cell-Signaling Networks Associated with Pichinde Virus Pathogenesis by Using Systems Kinomics
... Analysis of high-throughput kinomic data. We used a high- throughput kinase substrate array to investigate the host cell response to mild and lethal arenavirus infections. Hierarchical cluster analysis was used to ...
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Examination of the risk of reinfection with hepatitis C among injecting drug users who have been tested in Glasgow
... spontaneous viral clearance can be observed – and if also seen in those who have cleared infec- tion through antiviral therapy (Backmund, Meyer, & Edlin, 2004; Dalgard, 2005; Grebely et ...
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