Viral diversity
Measurements of Intrahost Viral Diversity Are Extremely Sensitive to Systematic Errors in Variant Calling
... patient-derived viral samples at a level sufficient for detec- tion of rare ...within-host viral diver- ...intrahost diversity and suggested the need for rigorous quality con- trol in such ...
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Duck gut viral metagenome analysis captures snapshot of viral diversity
... re-emerging viral diseases and prevent the transmission of viruses from the reservoir host, monitoring the virome status in the reservoir hosts is essential ...the viral diversity in the poultry gut ...
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Analysis of viral diversity for vaccine target discovery
... secondary viral infections, or between the strains of the vaccine and challenge infection, constitute a critical consideration for protective and, in some cases, pathologic immunity ...a viral species, most ...
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Viral Diversity Threshold for Adaptive Immunity in Prokaryotes
... high viral mutation ...rapid viral mutation by simply incorporating spacers at a higher ...high viral muta- FIG 4 Cost-benefit analysis of CRISPR-Cas ...the viral mutation ...high viral ...
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Viral diversity is an obligate consideration in CRISPR/Cas9 designs for targeting the HIV reservoir
... the diversity of circulating strains across a wide range of infected people, and dosing strategies must consider within-host diversity of HIV to maximize the probability of a functional ...
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A Strategy To Estimate Unknown Viral Diversity in Mammals
... unknown viral diversity (richness) in all mam- mals and the cost of ...and viral discovery for all mammalian viruses would be approximately ...estimated diversity would be disproportionately ...
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Metagenomic Analysis of the Viromes of Three North American Bat Species: Viral Diversity among Different Bat Species That Share a Common Habitat
... future viral zoonoses requires an in-depth understanding of the heterologous viral population in key animal species that will likely serve as reservoir hosts or intermediates during the next viral ...
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Viral Diversity of House Mice in New York City
... Viral discovery. We assayed pools of 2 to 4 samples representing the fecal pellets of mice trapped individually or in multicatch traps using UHTS. A total of 707,980,718 reads were generated from three lanes of ...
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Viral Diversity by Deep Sequencing: Approaches to Analyzing Effects of Anti-HIV Treatments
... heterogeneous viral strains in ...in viral loads and improvements in immune ...127,290 viral variants following quality filtering and error control by ...
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Unexpected Maintenance of Hepatitis C Viral Diversity following Liver Transplantation
... pretransplant diversity in the E1E2 region is lost during a viral bottleneck that follows transplantation, pos- sibly reflecting the outgrowth of fitter variants (2, 8, 9, 16, 32, 41, ...posttransplant ...
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Metagenomic Characterization of Airborne Viral DNA Diversity in the Near-Surface Atmosphere
... particular, viral genomes are so small that a large amount of viral particles must be obtained from air samples to be amplified, quantified, and ...to viral populations ...mospheric viral ...
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High Epstein-Barr Virus Load and Genomic Diversity Are Associated with Generation of gp350-Specific Neutralizing Antibodies following Acute Infectious Mononucleosis
... measurable diversity in minor variant gp350 pools during both AIM and CONV in all patient ...overall viral diversity both in the total number of variants and as the relative proportion of variants in ...
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Dynamics of Viral Evolution and Neutralizing Antibody Response after HIV-1 Superinfection
... sequence diversity were obtained from sliding win- dows (length, 150 bp; stride, 20 bp) for each of the three sequenced gene regions ...netic diversity and identification of nonredundant ...The viral ...
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Association between Latent Proviral Characteristics and Immune Activation in Antiretrovirus-Treated Human Immunodeficiency Virus Type 1-Infected Adults
... that viral charac- teristics such as sequence diversity may play a role in driving HIV-associated immune ...calculated viral diversity and divergence in the env and pol genes, and determined ...
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Genetic Diversity in RNA Virus Quasispecies Is Controlled by Host-Virus Interactions
... generate diversity through replicase error and recombination (16), but these experiments suggest that the differences are due to selection or bottlenecks imposed by the host-virus infection ...the viral ...
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In-Depth Analysis of a Heterosexually Acquired Human Immunodeficiency Virus Type 1 Superinfection: Evolution, Temporal Fluctuation, and Intercompartment Dynamics from the Seronegative Window Period through 30 Months Postinfection
... plasma viral load exceeded 400,000 copies/ml during the first 9 months of infection but resolved to the set point of 67,000 copies/ml by 3 months after superinfection; the CD4 cell count was 377 cells/ l at 30 ...
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Analysis of HIV Diversity in HIV-Infected Black Men Who Have Sex with Men (HPTN 061)
... HRM diversity assay to analyze HIV diversity in pediatric and adult ...HIV diversity among HIV- infected Black MSM who had high levels of non-suppressive ARV drug use and HIV drug resistance ...lower ...
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A cheap and open HIV viral load technique applicable in routine analysis in a resource limited setting with a wide HIV genetic diversity
... plasma viral load analyses, the Virology Depart- ment of Centre Pasteur of Cameroon uses two platforms: Generic HIV Viral Load assay (Biocentric, Bandol, France) and Abbott Real-Time HIV-1 assay (Abbott ...
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Genome-Wide Patterns of Intrahuman Dengue Virus Diversity Reveal Associations with Viral Phylogenetic Clade and Interhost Diversity
... interhost diversity in viral consensus genomes from viruses iso- lated from serum ...trahost diversity and have considerable limitations, in that they either characterize a few sequences at the ...
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High Variety of Known and New RNA and DNA Viruses of Diverse Origins in Untreated Sewage
... throughput viral discovery. A metagenomics analysis of purified viral particles in untreated sewage from the United States (San Francisco, CA), Nigeria (Maiduguri), Thailand (Bangkok), and Nepal (Kathmandu) ...
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