viral fusion
The Central Proline of an Internal Viral Fusion Peptide Serves Two Important Roles
... The fusion peptide of the avian sarcoma/leukosis virus (ASLV) envelope protein (Env) is internal, near the N terminus of its transmembrane (TM) ...internal viral fusion peptides, there is a proline ...
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Fusion Induced by a Class II Viral Fusion Protein, Semliki Forest Virus E1, Is Dependent on the Voltage of the Target Cell
... of viral fusion proteins have been identi- fied to date ...I viral protein is characterized, in its final, postfusion state, by the presence of a trimer of hairpins based on a central triple-stranded ...
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Molecular dynamics simulation analyses of viral fusion peptides in membranes prone to phase transition: effects on membrane curvature, phase behavior and lipid water interface destabilization
... membrane fusion induced by fusogenic pep- tides, molecular dynamic simulations of syn- thetic peptides, derived from viral fusion pro- teins, contained in lipid bilayers were ...HA fusion ...
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Neutralization of influenza virus by low concentrations of hemagglutinin-specific polymeric immunoglobulin A inhibits viral fusion activity, but activation of the ribonucleoprotein is also inhibited.
... Infectivity obtained in BHK cells by inducing fusion between the viral envelope and plasma membrane of nonneutralized A/PR/8 and virus neutralized with IgAa Growth of virus as % of contr[r] ...
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Mechanism of HIV-1 Resistance to an Electronically Constrained α-Helical Peptide Membrane Fusion Inhibitor
... HIV-1 fusion inhibitor that is highly effective against both wild-type and enfuvirtide (T20)-resistant ...impair viral Env-mediated cell fusion and entry, and change the conformation of the gp41 core ...
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Mutagenesis and Nuclear Magnetic Resonance Analyses of the Fusion Peptide of Helicoverpa armigera Single Nucleocapsid Nucleopolyhedrovirus F Protein
... quires fusion of the viral envelope and host cellular membrane to release the viral genome and accessory proteins into the host cell after appropriate receptor ...The fusion process is ...
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Dysregulated Glycoprotein B-Mediated Cell-Cell Fusion Disrupts Varicella-Zoster Virus and Host Gene Transcription during Infection
... via fusion of the virion membrane with cellular ...the fusion protagonist because X-ray crystal structures of this molecule from several herpesviruses show trimer formation reminis- cent of that of ...
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Intersubunit Interactions Modulate pH-Induced Activation of Membrane Fusion by the Junín Virus Envelope Glycoprotein GPC
... membrane fusion (44, ...membrane fusion are likely similar to those of other class I viral fusion proteins, such as influenza virus hemagglutinin (HA) and the retrovirus envelope glycoprotein ...
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The Membrane-Proximal Domain of Vesicular Stomatitis Virus G Protein Functions as a Membrane Fusion Potentiator and Can Induce Hemifusion
... for fusion potentiation of heterologous viral glycoproteins by ...the fusion protein (depicted as a trimeric molecule with globular heads) and GS (depicted as trimeric rectangles), represents the ...
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Membrane interaction and structure of the transmembrane domain of influenza hemagglutinin and its fusion peptide complex
... functional fusion peptide of influenza virus had a kinked helix structure with a fixed angle in the micellar environ- ...the fusion protein on the viral membrane and is involved in the late stages of ...
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Monoclonal antibodies detect different forms of influenza virus hemagglutinin during viral penetration and biosynthesis.
... One antibody Y8-10C2, shown previously to detect conformational alterations in the HA coinciding with the acid induction of viral fusion activity, bound to internalized virus but not to [r] ...
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Common principles and intermediates of viral protein mediated fusion: the HIV 1 paradigm
... domains, viral fusion proteins are currently categorized into three ...classes. Fusion proteins of retroviruses, filoviruses, coronaviruses, ortho- and paramyxoviruses displaying a prevalent α-hel- ...
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Identification of Clotrimazole Derivatives as Specific Inhibitors of Arenavirus Fusion
... the viral RNA-dependent RNA polymerase ...defines viral tropism (16, 17), whereas GP2 drives viral membrane ...I viral fusion proteins (30, ...LUJV fusion critically depends on ...
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Mutational Analysis of the Putative Fusion Domain of Ebola Virus Glycoprotein
... general, fusion peptides are rich in alanine and glycine ...other viral fusion pep- ...(15) fusion peptides, such mutations increased cell-to- cell fusion activity, while the same types ...
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Crystal Structures of Major Envelope Proteins VP26 and VP28 from White Spot Syndrome Virus Shed Light on Their Evolutionary Relationship
... of viral proteins (1, 11, 31–33, ...only viral protein structures showing a partial structural similarity are bluetongue virus VP7 (PDB accession code 1bvp; RMSD of ...
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Roles of the Putative Integrin-Binding Motif of the Human Metapneumovirus Fusion (F) Protein in Cell-Cell Fusion, Viral Infectivity, and Pathogenesis
... ␣51 and ␣v integrin-specific antibodies inhibit hMPV F pro- tein-induced cell-cell fusion. Previously, it has been shown that hMPV engages ␣v1 integrin to mediate virus infection, suggest- ing that integrins ...
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The cell biology of HIV 1 and other retroviruses
... of viral entry was high- lighted by Michel Tremblay whose work has historically focused on integral membrane-spanning intracellular adhesion molecules (ICAMs) that are incorporated within the envelopes of ...of ...
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Structure and Development of Viruses as Observed in the Electron Microscope IX. Entry of Parainfluenza I (Sendai) Virus
... This disadvantage in the study of Sendai virus, however, is more than offset by the striking fusion of viral membrane to cytoplasmic membrane which can be clearly visualized, and by the [r] ...
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Fusion properties of cells infected with human parainfluenza virus type 3: receptor requirements for viral spread and virus-mediated membrane fusion.
... The finding that bacterial neuraminidase treatment of cells infected at a low MOI allowed spread of the infection without cell fusion suggested that there are different sialic acid recep[r] ...
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Mutagenesis of Varicella-Zoster Virus Glycoprotein B: Putative Fusion Loop Residues Are Essential for Viral Replication, and the Furin Cleavage Motif Contributes to Pathogenesis in Skin Tissue In Vivo
... The structures of gB in the two human alphaherpesviruses, VZV and herpes simplex virus type 1 (HSV-1), are likely to be very similar as they have 49% amino acid identity (reviewed in reference 16). The ectodomain of ...
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