viral integration
Common Viral Integration Sites Identified in Avian Leukosis Virus Induced B Cell Lymphomas
... A custom Perl pipeline was developed to analyze the aligned reads’ output from Bowtie. Briefly, reads containing sequencing errors were fil- tered, and read counts and sonication breakpoints were quantified. Inte- ...
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Overexpression of ecotropic viral integration site-1 is a prognostic factor of lung squamous cell cancer
... Ecotropic viral integration site-1 (EVI1) is identified as an oncoprotein mostly in hematological malignancies such as acute myelogenous leukemia (AML) and myelo- dysplastic syndrome ...
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Viral integration drives multifocal HCC during the occult HBV infection
... However, CSMD2 is fairly large protein with approximately 380KDa molecular mass and therefore, at the time of our manuscript preparation, we are unable to transduce its ex- pression in HCC cell lines to further address ...
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GCN5 dependent acetylation of HIV 1 integrase enhances viral integration
... the integration step of HIV-1 replication cycle as demonstrated by the reduced infectivity, due to inefficient provirus formation, in GCN5 knockdown ...virus integration, the residue exclusively modified by ...
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Sequence Variation of Human Papillomavirus Type 16 and Measurement of Viral Integration by Quantitative PCR
... true integration status was un- ...any integration-related misinterpretation that might arise with the use of clinical ...the integration of the HPV ...
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Genetic evidence that the avian retrovirus DNA endonuclease domain of pol is necessary for viral integration.
... Quantitation of the amount of DNA synthesized by wildtype and mutant pt127 infections demonstrated that the mutant virus-infected cells contained more unintegrated viral DNA than wild-ty[r] ...
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The role of HIV integration in viral persistence: no more whistling past the proviral graveyard
... as viral integration site (Table ...and viral integration site (Table ...that integration is an important mechanism for persistence and clonal expansion of HIV-infected ...
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The role of unintegrated DNA in HIV infection
... for viral integration, so it was surprising that one study noted that integrase-defective virus could nonetheless yield synthesis of all viral gene products and to productive infection itself ...
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Stabilization of Telomere G-Quadruplexes Interferes with Human Herpesvirus 6A Chromosomal Integration
... chromosomal integration was first thought to be an evolution- ary dead-end, it is now thought to be a way HHV-6A/B, and several other herpesviruses that harbor telomeres at their genome ends, maintain their virus ...
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microRNAs in viral oncogenesis
... by viral integration in their vicinity ...induced viral hepato-carcinogenesis a large number of viral inte- gration events occur near or within fragile sites and/or other cancer-associated ...
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The loss of outer capsid protein P2 results in nontransmissibility by the insect vector of rice dwarf phytoreovirus.
... mixed with extraction solution (0.05 M Tris-HCl [pH 7.5], 5.0 M urea, 0.35 M NaCl, 0.02 M EDTA, 2% sarcosyl, and 5% phenol). SDS was added to 0.2% (wt/vol) and mixed for 10 min. The mixture was extracted three times with ...
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The Cellular Protein Daxx Interacts with Avian Sarcoma Virus Integrase and Viral DNA To Repress Viral Transcription
... Daxx and PML as interferon-induced repressors of viral gene expression. Treatment of HeLa cells with alpha inter- feron induces Daxx expression (our unpublished data). As the amount of Daxx protein increases after ...
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Episomal amplification or chromosomal integration of the viral genome: alternative pathways in hamster polyomavirus-induced lymphomas.
... of viral information in the cell progeny requires the establishment of a nonproductive infection, nec- essary in order to prevent a lethal-virus productive ...the viral DNA resulting from its ...
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Transcriptional Coactivator LEDGF/p75 Modulates Human Immunodeficiency Virus Type 1 Integrase-Mediated Concerted Integration
... full-site integration product ...represents integration of another donor into the full-site product or other DNA struc- ...the integration products ...
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Subcellular Localization and Integration Activities of Rous Sarcoma Virus Reverse Transcriptase
... low integration activity of RSV RT suggests that it might not be biologically relevant; however, we cannot yet exclude activation of RT by other proteins in ...for integration in vitro, the catalytic ...
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Drug resistant integrase mutants cause aberrant HIV integrations
... of viral DNA as plasmids in Escherichia coli was derived from pHIV-SH ...the viral RNA, pSICO-LZF, was derived from pSICO- XBX by inserting the shuttle cassette and the eGFP cod- ing region as a NotI–MluI ...
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Genetic analysis of bovine papillomavirus type 1 trans-acting replication factors.
... Taken together, the mutational analysis of the El region with respect to BPV-1 replication leads us to conclude that integration of the viral genome occurs when the function of this part[r] ...
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Features of two hepatitis B virus (HBV) DNA integrations suggest mechanisms of HBV integration.
... On the basis of this analysis, we suggest a mechanism for integration of the viral DNA molecule which involves strand invasion of the 3' end of the L negative strand of an open circular [r] ...
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Retroviral cDNA Integration: Stimulation by HMG I Family Proteins
... In this study and in previous work (16), we have presented four lines of evidence supporting the idea that HMG I(Y) is a likely cofactor for integration in vivo. (i) We found that HMG I(Y) is associated with MoMLV ...
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Proviral DNA integration and transcriptional patterns of equine infectious anemia virus during persistent and cytopathic infections.
... The relatively high proportion of proviral DNA integration and the simple pattern of viral transcription observed during EIAV infections appeared to be different from the generally obser[r] ...
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