Viral latency
FoxO1 Suppresses Kaposi’s Sarcoma-Associated Herpesvirus Lytic Replication and Controls Viral Latency
... of latency and lytic replication ...KSHV latency and lytic replication. During KSHV latency, most viral genes are silenced, with the exceptions being several latent genes, including vFLIP ...
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Activation of Vav by the Gammaherpesvirus M2 Protein Contributes to the Establishment of Viral Latency in B Lymphocytes
... diated viral latency is well illustrated by the persistent high levels of latently infected GC B cells observed in both vav1 ⫺/⫺ and vav2 ⫺/⫺ mice upon MHV-68 ...of viral replication and elimination ...
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Inhibition of Superinfection and the Evolution of Viral Latency
... the viral protein pV to the single-stranded DNA (ssDNA) in order to limit the number of double-stranded DNA (dsDNA) repli- cative forms ...of latency and superin- fection in latent viruses, similar ...
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p30 protein: a critical regulator of HTLV 1 viral latency and host immunity
... the viral protein p28, shares many characteristics with p30 ...of viral replication and persistence, which might affect pathogenic outcome [37, 38, 50, 64, ...Both viral products are encoded by a ...
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HIV interactions with monocytes and dendritic cells: viral latency and reservoirs
... the viral promoter is essential for HIV-1 transcription ...in viral pathogenesis [28]. Retro- viral-mediated HIV-1 Nef expression in primary mono- cytes and a promonocytic cell line inhibits ...
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Induction of Protective Immunity against Murine Gammaherpesvirus 68 Infection in the Absence of Viral Latency
... the viral genomes were detected in the brain tissues of mice infected with M3-FL/AC-RTA, as well as in those of mice infected with M3-FL/MHV-68 (data not ...The viral DNA was at a lower level in the brain ...
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The Viral Latency-Associated Nuclear Antigen Augments the B-Cell Response to Antigen In Vivo
... Other B-cell-tropic herpesviruses provide examples of mech- anistically different scenarios, which nevertheless yield the same result. EBV latent genes also confer a proliferative ad- vantage upon B cells in transgenic ...
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Myeloblastic Cell Lines Mimic Some but Not All Aspects of Human Cytomegalovirus Experimental Latency Defined in Primary CD34+ Cell Populations
... Viral latency prevents immunological clearance of HCMV infec- ...HCMV latency is a crucial first step in developing prophylactic or therapeutic regi- mens targeting ...
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Transcription of the Herpes Simplex Virus Latency-Associated Transcript Promotes the Formation of Facultative Heterochromatin on Lytic Promoters
... the viral latency-associated transcript (LAT) promotes lytic gene silencing and the association of one heterochromatin marker, dimethylation of lysine 9 on histone H3 (H3K9me2), with viral lytic ...
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Characterization of a Spontaneous 9.5-Kilobase-Deletion Mutant of Murine Gammaherpesvirus 68 Reveals Tissue-Specific Genetic Requirements for Latency
... of viral latency (day 14 postinfection) ...splenic viral titers after intraperitoneal ...in latency or reactivation ...during latency, a deletion within the M1 gene results in increased ...
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NF-κB p50 Plays Distinct Roles in the Establishment and Control of Murine Gammaherpesvirus 68 Latency
... splenic latency differs from the latency phenotype of CD40 ⫺/⫺ B cells in CD40 ⫹/⫹ /CD40 ⫺/⫺ mixed BM chimeric ...support latency at an early time point but diminished in frequency over time ...in ...
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Splicing Factor 3B Subunit 1 Interacts with HIV Tat and Plays a Role in Viral Transcription and Reactivation from Latency
... is viral latency in resting CD4 T cells and other reservoirs ...the viral genome, and using latency- reversing agents (LRAs), the “shock and kill” ...by viral cytopathic effects or ...
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Murine Gammaherpesvirus 68 LANA Is Essential for Virus Reactivation from Splenocytes but Not Long-Term Carriage of Viral Genome
... the viral genome at the termi- nal repeats would prevent the expression of viral genes en- coded across the fused terminal repeats ...of viral latency in vivo are currently ...such ...
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Neurodevelopmental assessment of HIV exposed uninfected and early treated HIV infected children: study protocol
... Study participants will be recruited from an existing cohort of early-treated HIV-infected and HEU children enrolled onto a clinical trial investigating viral latency and early neonatal provision of ...
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Exhaustion and Inflation at Antipodes of T Cell Responses to Chronic Virus Infection
... Keywords: Immune Exhaustion; Memory Inflation; Chronic Virus Infection; Viral Latency; Viral 11.. Persistence; CD8 T-cell 12.[r] ...
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Altered human cytomegalovirus-encoded miRNAs in host circulation: novel disease biomarkers and potential aetiological agents
... from latency, and the expression of HCMV-encoded miRNAs is observed in all phases of viral life cycle and can interfere both viral and host genes to facilitate viral immunoevasion, ...
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CD8 T Cells Control Cytomegalovirus Latency by Epitope-Specific Sensing of Transcriptional Reactivation
... According to the hypothesis, the mutation L176A in IE1 should increase the frequency of detectable transcriptional events, i.e., the point prevalence of transcription, not by in- creasing the rate and incidence of ...
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The Murine Gammaherpesvirus 68 M2 Gene Is Required for Efficient Reactivation from Latently Infected B Cells
... established latency in bulk splenocytes at a comparable levels to wt ...B-cell latency in the spleens of mice in the absence of a functional M2 ...B-cell latency was detected upon low-dose ...
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Heterologous Viral Promoters Incorporated into the Human Cytomegalovirus Genome Are Silenced during Experimental Latency
... upon viral protein production for its activation ...novo viral proteins for activation extended to SV40 promoter-driven GFP transgenes recombined into either end of the US region in two clinical strains of ...
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Lungs are a major organ site of cytomegalovirus latency and recurrence.
... In a murine model of CMV latency, the lungs were identified as an authentic site of latent infection, since the viral genome remained detectable in lung tissue even after it was cleared [r] ...
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