Viral pathogenesis
The ORF3 Protein of Porcine Circovirus Type 2 Is Involved in Viral Pathogenesis In Vivo
... in viral pathogenesis in vivo, we inoculated 8-week-old BALB/c mice that have been developed for PCV2 replication with ORF3-deficient mutant PCV2 ...of viral DNA and antigens were detected in the ...
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Involvement of the Zinc-Binding Capacity of Sendai Virus V Protein in Viral Pathogenesis
... It seems that the highly conserved cysteine residues are involved both in the zinc-binding capacity of the Vu domain and in viral pathogenesis in vivo. Although some enzymes utilize zinc in their active ...
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Interferon-Induced Ifit Proteins: Their Role in Viral Pathogenesis
... (B) Viral strategies to evade Ifit1’s antiviral ...of viral mRNAs if the caps have no 2=-O-methylation and inhibits their translation by blocking the access of eIF4e to the ...Many viral mRNAs evade ...
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The L Gene of J Paramyxovirus Plays a Critical Role in Viral Pathogenesis
... consist of two major viral components, the phosphoprotein (P) and the large (L) protein. The L protein, with ⬎2,000 amino acid residues in a single polypeptide chain, is thought to be responsible for the enzymatic ...
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Replication of Murine Cytomegalovirus in Differentiated Macrophages as a Determinant of Viral Pathogenesis
... The results of these studies support the hypothesis that mac- rophages play a pivotal role in the pathogenesis of MCMV infections. Initially, these cells may serve as target cells in at least the spleen, and the ...
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Mechanisms of viral pathogenesis Distinct forms of reoviruses and their roles during replication in cells and host
... Other components and processes of cells and host utilized by reoviruses for replication include a intestinal M cells, which normally transport antigenic substances from the intestinal lu[r] ...
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Influenza A Virus PB1-F2 Protein Contributes to Viral Pathogenesis in Mice
... augment viral replication or modulate the host innate immune responses, thereby enhancing pathogenesis of the dis- ease ...the viral polymerase genomic segments with those of a modern H1N1 strain ...
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TR1.3 Viral Pathogenesis and Syncytium Formation Are Linked to Env-Gag Cooperation
... were equivalent (34). In previous studies, we also demon- strated that cell fusion is dependent on the level of virus re- ceptor (10); thus, both Env and receptor expression levels mediate cell fusion potential. This ...
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Protective anti-reovirus monoclonal antibodies and their effects on viral pathogenesis.
... We now report that i MAbs specific for each of the reovirus outer capsid proteins and the core spike protein are protective under certain circumstances, ii MAb protection does not univer[r] ...
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The role of the ectromelia virus protein p28 in apoptosis and viral pathogenesis
... Tables and Figures Table 1.1 Mechanisms of viral inhibition of apoptosis Figure 1.1 Morphological characteristics of apoptosis Figure 1.2 Pathways to apoptosis Figure Pathways of TNF rec[r] ...
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Encephalomyocarditis Virus 2A Protein Is Required for Viral Pathogenesis and Inhibition of Apoptosis
... EMCV is known as a cytolytic virus. When lysis (necrosis) occurs, the plasma membrane breaks down, allowing release of virions, cellular components, and proinflammatory molecules that can damage tissue and give rise to ...
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Viral Internal Ribosome Entry Site Elements: Novel Ribosome-RNA Complexes and Roles in Viral Pathogenesis
... most viral IRES-containing ...stranded viral RNA genomes ...the viral life cycle, mostly to ensure efficient viral translation when components of the host translation machinery are limited due ...
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Rapid Pathogenesis Induced by a Vesicular Stomatitis Virus Matrix Protein Mutant: Viral Pathogenesis Is Linked to Induction of Tumor Necrosis Factor Alpha
... Because VSV replication is entirely cytoplasmic, VSV can inhibit host responses to infection by blocking mRNA trans- port from the nucleus to the cytoplasm. VSV M protein, in addition to being a major viral ...
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Evaluation of the Contributions of Individual Viral Genes to Newcastle Disease Virus Virulence and Pathogenesis
... In this study we chose two viruses, BC and GBT, which differ substantially in virulence but are a genetically closely related pair. Specifically, both viruses are of chicken origin from the United States from the late ...
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Exploring the role of bacteria in viral reactivation and pathogenesis
... the viral infection but also to treating the presence of ...favor viral replication ...the pathogenesis of each ...of viral genes that modulate cellular ...facilitates viral ...
The interaction of hepatitis B virus with the ubiquitin proteasome system in viral replication and associated pathogenesis
... eliminate viral components of HBV and blocks the viral life ...of viral proteins and contribute to viral ...both viral replication and hepatocarcinogenesis during HBV infection ...in ...
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Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection
... acute viral infection of the CNS (61), our study suggests that patients with acute WNV encephalitis and persistent cerebellar inflammation and disease symptoms might benefit from VLA-4 ...during viral ...
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Cellular and Humoral Immunity in the Pathogenesis of Recurrent Herpes Viral Infections in Patients with Lymphoma
... suppression of cellular immunity to the specific herpes viral antigen preceded each episode of reactivation, but recurrent infection did not occur in all patients with diminished specific lymphocyte ...
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Murine Cytomegalovirus Deubiquitinase Regulates Viral Chemokine Levels To Control Inflammation and Pathogenesis
... Additionally, several herpesvirus DUBs have been ascribed roles in pathogenesis. The DUB of pseudorabies virus (PRV) targets itself for deubiquitination, allowing transmission to nerve termini and subsequent ...
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Enterovirus 71-induced autophagy increases viral replication and pathogenesis in a suckling mouse model
... on pathogenesis as well as viral titer, 7-day-old ICR mice were ...after viral challenge followed by weight loss (Figure 3B, left panel) and death (Figure 3B, right ...
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