Virion assembly and release
The Conserved Carboxy Terminus of the Capsid Domain of Human Immunodeficiency Virus Type 1 Gag Protein Is Important for Virion Assembly and Release
... the assembly of virion ...of virion production, but mutations in the hinge region demonstrated the most significant ...HIV-1 virion assembly and release and define a putative ...
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The C terminus of NS5A domain II is a key determinant of hepatitis C virus genome replication, but is not required for virion assembly and release.
... School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK The NS5A protein of hepatitis C virus (HCV) plays ...
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The Carboxy-Terminal Fragment of Nucleolin Interacts with the Nucleocapsid Domain of Retroviral Gag Proteins and Inhibits Virion Assembly
... and virion assembly, the mutation was trans- ferred to the complete proviral ...mediate virion assembly and release directly, 293T cells were transfected with the L477P mutant or the ...
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Zika Virus NS2A Mediated Virion Assembly
... ⬎ 12-fold-higher extracellular viral RNA levels (Fig. 8D), leading to significantly higher extracellular/intracellular viral RNA ratios (Fig. 8E). The result suggests that 3= UTR SL-2 RNA increases the efficiency of ...
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Using a Virion Assembly-Defective Dengue Virus as a Vaccine Approach
... of virion assembly/release, we transfected the three mutant genome-length RNAs individually into BHK-21 cells that constitutively expressed DENV-2 WT NS2A ...
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Involvement of a Bovine Viral Diarrhea Virus NS5B Locus in Virion Assembly
... the assembly defect in 5B-741 mutants is associated with a failure to couple RNA replication with virion ...the assembly and release of infectious ...essential virion assembly ...
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Hepatitis C Virus-Induced Rab32 Aggregation and Its Implications for Virion Assembly
... Because the Rab GTPase switches between GDP- and GTP-bound forms that deter- mine its specific activities, it is important to know whether there is a difference in the nucleotide status of Rab32 between naive and ...
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Subcellular Localization of HIV-1 gag-pol mRNAs Regulates Sites of Virion Assembly
... association with intracellular vesicles) (Fig. 7B, and see the quantification in Fig. 7C). Thus, gRNA-directed Gag trafficking to the “wrong” cellular membranes was likely to explain the bulk of the virus particle ...
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Linker insertion mutations in the human immunodeficiency virus type 1 gag gene: effects on virion particle assembly, release, and infectivity.
... to release extracellular particles, it is likely that these mutants had defects both in the ability to make stable intracytoplasmic particles and in the ability to release ...
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Wrapping up the bad news – HIV assembly and release
... enveloped virion with the conical core and maturation of the loosely associated paired RNA ge- nomes into a mature tightly linked ...viral assembly [6,168,169] and even trace amounts of nucleic acid appear ...
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Vaccinia Virus A6 Is Essential for Virion Membrane Biogenesis and Localization of Virion Membrane Proteins to Sites of Virion Assembly
... of Virion Membrane Proteins to Sites of Virion Assembly Xiangzhi Meng, Addie Embry, Lloyd Rose, Bo Yan, Chungui Xu, and Yan Xiang Department of Microbiology and Immunology, The University of Texas ...
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Heterogeneity of vesicular stomatitis virus particles: implications for virion assembly.
... Vesicular stomatitis virus (VSV) particles formed at early times after infection.. contain only one-third the amount of viral glycoprotein (G protein), relative to.[r] ...
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The Functional Oligomeric State of Tegument Protein GP41 Is Essential for Baculovirus Budded Virion and Occlusion-Derived Virion Assembly
... for virion assembly, and it is possible that GP41, the major tegument protein, is a highly multifunctional protein which is exposed on the outside of nucleocapsids and executes a very different envelopment ...
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Uukuniemi Phlebovirus Assembly and Secretion Leave a Functional Imprint on the Virion Glycome
... with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC- SIGN-dependent cellular attachment are predominant on ...Local virion structure and the route of ...
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Palmitoylations on Murine Coronavirus Spike Proteins Are Essential for Virion Assembly and Infectivity
... Exposure of MHV-infected 17cl1 cells to higher doses of 2-BP abrogated S-mediated syncytial activities. 2-BP did not arrest S transport to cell surfaces; in fact, the opposite occurred as the underpalmitoylated S ...
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Kinetics of utilization of Sendai virus RNA and protein in the process of virion assembly.
... the NP and P proteins synthesized early and the M and F proteins synthesized late were preferentially incorporated into virus relative to the other viral proteins.. The kinetics of incor[r] ...
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Novel Role of vBcl2 in the Virion Assembly of Kaposi's Sarcoma-Associated Herpesvirus
... IMPORTANCE KSHV, an important human pathogen accounting for a large percent- age of virally caused cancers worldwide, has evolved a variety of stratagems for evading host immune responses to establish lifelong persistent ...
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Rous sarcoma virus mutant LA3382 is defective in virion glycoprotein assembly.
... viral glycoprotein in either mutant or wild-type virus-infected cells was found in the form of the precursor, Pr95. This is consistent with a pre- vious report (10) that cleavage of the [r] ...
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Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the Virion Glycome
... with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC- SIGN-dependent cellular attachment are predominant on ...Local virion structure and the route of ...
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HIV 1 Assembly, Release and Maturation
... include assembly of structural precursors, budding of the new particle and maturation into fully infectious ...appropriate assembly of structural components, the efficient re- cruitment of viral and cell ...
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