Virulence and Pathogenesis
Role of Sialic Acid Binding Specificity of the 1918 Influenza Virus Hemagglutinin Protein in Virulence and Pathogenesis for Mice
... The experiments described in this report emphasize the complexity of the relationship between SA binding specificity and virulence and pathogenesis in IAV infection and highlight several important ...
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Evaluation of the Contributions of Individual Viral Genes to Newcastle Disease Virus Virulence and Pathogenesis
... in virulence but are a genetically closely related ...in virulence between rBC and ...their virulence in chickens in six different as- says: (i) in vitro replication kinetics and magnitude; (ii) ...
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In vivo and in vitro Pathogenesis and Virulence Factors of Candida albicans Strains Isolated from Cutaneous Candidiasis
... the pathogenesis of Candida species when invading vaginal and gastrointestinal ...the virulence and pathogenesis of Candida-related infections, the data from host-fungal pathogen interaction will be ...
9
Nectin-4 Interactions Govern Measles Virus Virulence in a New Model of Pathogenesis, the Squirrel Monkey (Saimiri sciureus)
... ABSTRACT In addition to humans, only certain nonhuman primates are naturally sus- ceptible to measles virus (MeV) infection. Disease severity is species dependent, ranging from mild to moderate for macaques to severe and ...
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Accidental Virulence, Cryptic Pathogenesis, Martians, Lost Hosts, and the Pathogenicity of Environmental Microbes
... microbial pathogenesis since the germ theory of disease was proposed in the late 19th ...regards virulence as a microbial characteristic, is supported by the observation that certain microbes require ...
6
SuhB Is a Regulator of Multiple Virulence Genes and Essential for Pathogenesis of Pseudomonas aeruginosa
... ABSTRACT During initial colonization and chronic infection, pathogenic bacteria encounter distinct host environments. Adjust- ing gene expression accordingly is essential for the pathogenesis. Pseudomonas ...
10
Hemolysins of Staphylococcus aureus—An Update on Their Biology, Role in Pathogenesis and as Targets for Anti Virulence Therapy
... the pathogenesis of pneumonia in ...reduced virulence in invasive disease models of pneumonia [32] [41] dermonecrotic skin infection, sepsis, peritonitis, and infection of the cornea [34], central nervous ...
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A transcription factor contributes to pathogenesis and virulence in Streptococcus pneumoniae
... of virulence factors during infection of the host to establish ...adaptation, pathogenesis and virulence ...of virulence gene expression is governed by ToxR and ToxT ...
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Molecular Determinants of Severe Acute Respiratory Syndrome Coronavirus Pathogenesis and Virulence in Young and Aged Mouse Models of Human Disease
... extreme virulence of SARS-CoV remains ...increased pathogenesis of MA15 in rodents, we used reverse genetics and evaluated the virulence of panels of derivative viruses encoding various combinations ...
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Subinhibitory Antibiotic Therapy Alters Recurrent Urinary Tract Infection Pathogenesis through Modulation of Bacterial Virulence and Host Immunity
... bacterial virulence in vitro has recently been brought to light, raising concerns over the appropriateness of low-dose therapies, including antibiotic prophylaxis for recurrent urinary tract infection ...
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Ralstonia solanacearum Requires PopS, an Ancient AvrE Family Effector, for Virulence and To Overcome Salicylic Acid Mediated Defenses during Tomato Pathogenesis
... reduced virulence on agriculturally important Solanum ...type virulence on a weed host, Solanum dulcamara, suggesting that some species can avoid the effects of ...SA-triggered pathogenesis-related ...
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Virulence and pathogenesis of chytridiomycosis: a lethal disease of amphibians
... of virulence and the mechanisms driving disease epidemics (Bull 1994, Ebert 1998, Ebert & Bull ...extension, virulence, have been investigated using serial passage experiments in which parasites are ...
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Altering the Expression Kinetics of VP5 Results in Altered Virulence and Pathogenesis of Herpes Simplex Virus Type 1 in Mice
... While many herpes simplex virus (HSV) structural proteins are expressed with strict-late kinetics, the HSV virion protein 5 (VP5) is expressed as a “leaky-late” protein, such that appreciable amounts of VP5 are made ...
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Accessory Gene Regulator 1 Locus Is Essential for Virulence and Pathogenesis of Clostridium difficile
... difficile pathogenesis have not been clear until ...difficile pathogenesis and opens up a unique therapeutic target for the development of a novel nonantibiotic therapy for ...
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Virulence and pathogenesis of chytridiomycosis: a lethal disease of amphibians
... mortality can occur in a wide range of amphibian species. Additionally, the ability of Bd to respond to a wide range of environmental conditions (temperatures and nutrient conditions) in ways that potentially alter the ...
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A Novel Virulence Phenotype Rapidly Assesses Candida Fungal Pathogenesis in Healthy and Immunocompromised Caenorhabditis elegans Hosts
... pathogen’s virulence (34). Yet, it is important to remember that virulence can be broadly measured as any reduction in host fitness resulting from interactions between a pathogen and its host ...assessed ...
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First report of cavitary pneumonia due to community acquired Acinetobacter pittii, study of virulence and overview of pathogenesis and treatment
... elegans killing assays and the BioFilm Ring Test® showed very low virulence potential and a poor ability to form biofilm as recently observed [11, 12]. The significant variability of virulence described ...
6
Pathogenesis of Oral Candidiasis
... 21. Hornby JM, Jensen EC, Lisec AD, Tasto JJ, Jahnke B, Shoemaker R, Dussault P, Nickerson KW. Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. Applied Environ Microbiology 2001; 67: ...
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Mitochondria and Fungal Pathogenesis: Drug Tolerance, Virulence, and Potential for Antifungal Therapy
... vival under oxidative stress in C. albicans, C. neoformans, A. fumigatus, and Paracoccidioides brasiliensis (1, 54, 56, 62), as well as the role of mitochondria in fungal morphogenesis (1, 46, 56, 57, 87). With respect ...
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Sub-Inhibitory Antibiotics Enhance Virulence, Persistence, and Pathogenesis of Uropathogens
... induced virulence expression could easily exacerbate an already complicated infection. The observation that resistant organisms are also in many cases hypervirulent may be a direct, yet unexplored consequence of ...
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