Virus-induced proteasomal degradation
Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells
... the proteasomal degradation of SK1 via a mechanism that is only partially dependent on direct binding to SK1 ...herpes virus positive patient-derived primary effusion lymphoma cells ...
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Mouse Mammary Tumor Virus Signal Peptide Uses a Novel p97 Dependent and Derlin Independent Retrotranslocation Mechanism To Escape Proteasomal Degradation
... ERAD components also are used by mouse mammary tumor virus (MMTV). MMTV is a complex retrovirus that encodes several regulatory and accessory proteins, including Rem (25–27). Rem is a precursor protein that is ...
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Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation
... are induced in response to viral infection and stimulate the expression of interferon-stimulated genes (ISGs), including that encoding viperin (virus- inhibitory protein, endoplasmic reticulum associated, ...
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Human Immunodeficiency Virus Type 1 Vpr Links Proteasomal Degradation and Checkpoint Activation
... mutated and Rad3-related protein (ATR). ATR is a sensor of replication stress. Replication stress is a cellular condition that results from the stalling of replication forks as a consequence of various cellular insults, ...
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Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells
... the proteasomal degradation of SK1 via a mechanism that is only partially dependent on direct binding to SK1 ...herpes virus positive patient-derived primary effusion lymphoma cells ...
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HIV 1 Tat Recruits HDM2 E3 Ligase To Target IRF 1 for Ubiquitination and Proteasomal Degradation
... and virus-induced physiological ...(Ag)- induced lymphocyte activation (6, 7), as well as activation of cell proliferation and increase of cell survival (8, ...increases virus infectivity and ...
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Herpes Simplex Virus Immediate-Early Protein ICP0 Is Targeted by SIAH-1 for Proteasomal Degradation
... SIAH-1 binding is dispensable for ICP0-mediated PML deg- radation. Our finding that ICP0 interacts and stabilizes the cellular E3 ubiquitin ligase SIAH-1 and a previous report dem- onstrating that SIAH-1 is able to ...
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Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62
... autophagosomal degradation after 6 h BafA1 treatment would interfere with viral ...DENV induced a full block of the autophagic flux resulting in increased steady-state AVs ...
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Classical Swine Fever Virus Npro Interacts with Interferon Regulatory Factor 3 and Induces Its Proteasomal Degradation
... After virus infection of a cell, pattern recognition receptors recognize viral elements, such as dsRNA, single- stranded RNA, DNA, or viral glycoproteins, depending on the virus (for selected reviews, see ...
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Triptolide inhibits human immunodeficiency virus type 1 replication by promoting proteasomal degradation of Tat protein
... Although the advent of HAART changed the landscape of HIV/AIDS, there is still no cure for this disease cur- rently available. Therefore, the discovery and develop- ment of novel therapeutics for HIV infection is still ...
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Transformation by E1A Oncoprotein Involves Ubiquitin-Mediated Proteolysis of the Neuronal and Tumor Repressor REST in the Nucleus
... rapid degradation by the ubiquitin-proteasome ...REST degradation was blocked by the ubiq- uitination inhibitor PYR-41 and the proteasome inhibitor MG-132 but not by the nuclear export inhibitor leptomycin ...
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Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation
... the proteasomal degradation of SK1 via a mechanism that is only partially dependent on direct binding to SK1 (Loveridge et ...the proteasomal degradation of SK1a and SK1b (which has an 86 ...
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Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via Unfolded Protein Response Signaling
... Figure 1: Effect of SMIP004 on global gene expression in LNCaP-S14 cells. (A) LNCaP-S14 cells were treated with DMSO, SMIP004 (40 µM) or bortezomib (BTZ, 50 nM), camptothecin (CPT, 500 nM) or roscovitine (RVT, 20 µM) for ...
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Kaposi's Sarcoma-Associated Herpesvirus RTA Promotes Degradation of the Hey1 Repressor Protein through the Ubiquitin Proteasome Pathway
... tion has previously been observed using siRNAs (65). There- fore, to test this hypothesis, we performed experiments using siRNAs to knock down Hey1 expression in cells latently in- fected with KSHV. Due to the poor ...
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Hsp90 Chaperones Bluetongue Virus Proteins and Prevents Proteasomal Degradation
... on virus titers, which neither increased nor decreased ...in virus titer evident ...or virus titer, mediating neither increases nor decreases, independent of inhibition prior to or after ...
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Sphingosine kinase1 : a potential therapeutic target in pulmonary arterial hypertension?
... More recent studies have questioned the role of SphK1 and S1P in promoting vascular remodeling, while maintaining some agreement concerning vascular smooth muscle contractility. In this regard, chronic treatment with ...
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SAMHD1: a new insight into HIV 1 restriction in myeloid cells
... with virus-like particles derived from SIV ...for proteasomal degradation in myeloid cells through the E3 ubiquitin ligase complex [5,6], prompting the search for the unknown HIV-1 restriction factor ...
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Targeting Swine Leukocyte Antigen Class I Molecules for Proteasomal Degradation by the nsp1α Replicase Protein of the Chinese Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Strain JXwn06
... somal degradation? There are rich cases that viruses take over the ubiquitin system for their own ...simplex virus ICP0 (56), adenovirus E1b 55k (57), Kaposi’s sarcoma-associated herpesvi- rus (KSHV) K3 and ...
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Regulation of vascular endothelial growth factor expression by homeodomain-interacting protein kinase-2
... Collectively, the data presented in this study indicated that HIPK2 could repress the β-catenin transcription activ- ity and downregulate VEGF expression in tumor cells. Constitutive activity of β-catenin can exert both ...
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Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators
... proteasome-mediated degradation of signaling ...defective proteasomal degradation of such mediators, which in turn caused dysfunction in three major cilia-associated signaling pathways (Shh, Wnt, and ...
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