voltage-gated calcium channel
Deletion of a specific exon in the voltage gated calcium channel gene cacophony disrupts locomotion in Drosophila larvae
... TAR DNA-binding protein 43 (TDP-43) is an RNA-binding protein that regulates transcription, translation and alternative splicing of mRNA. We have shown previously that null mutations of the Drosophila ortholog, Tar ...
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Lung adenocarcinoma with Lambert–Eaton myasthenic syndrome indicated by voltage gated calcium channel: a case report
... anti-P/Q-type voltage-gated calcium channel (VGCC) anti- body level has been used, in addition to clinical manifesta- tions and nerve conduction studies, to diagnose ...
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Dominant-negative synthesis suppression of voltage-gated calcium channel Cav2.2 induced by truncated constructs
... Voltage-gated calcium channel ␣ 1 subunits consist of four domains (I–IV), each with six transmembrane ...single channel level, when channels were recorded, there were no differences in ...
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Calcium Channel Trafficking Blocker Gabapentin Bound to the α2δ-1 Subunit of Voltage-Gated Calcium Channel: A Computational Structural Investigation
... 11. Barclay, J.; Balaguero, N.; Mione, M.; Ackerman, S.L.; Letts, V.A.; Brodbeck, J.; Canti, C.; Meir, A.; Page, K.M.; Kusumi, K.; Perez-Reyes, E.; Lander, E.S.; Frankel, W.N.; Gardiner, R.M.; Dolphin, A.C.; Rees, M. ...
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The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology
... present in C. elegans, and is localized to the presynaptic active zone [15]. At synapses UNC-2 regulates calcium ion entry that facilitates synaptic vesicle exocytosis [16]. It is the reduced neural transmission ...
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Voltage gated calcium channel currents in human coronary myocytes Regulation by cyclic GMP and nitric oxide
... for voltage-gated Ca2+ entry in human coronary myocytes; (b) their inhibition by agents stimulating nitric oxide and/or intracellular cGMP production is expected ...
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A mutation in the low voltage-gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia
... in voltage sensing. Since simultaneous activation of all four voltage sensors is required to open the calcium channel, the arginine residue mutated in the affected individuals is ...
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Cloning and Characterization of Alternatively Spliced Voltage-Gated Calcium Channel Subunits.
... the voltage dependence of activation, as well as a decrease in the rate of ...the voltage dependence of activation means that a stronger membrane depolarization is required to activate the channel ...
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The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study
... (voltage-gated) calcium channel (LTCC) antagonists (also called calcium blockers or calcium antagonists) such as verapamil and nifedipine are licensed and widely used to treat ...
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Current statins show calcium channel blocking activity through voltage gated channels
... the calcium curves to right in relatively in less amount ...of voltage gated calcium channels that warrants for reassessment of its dosimetry particularly in presence of other voltage ...
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Genetic Analysis of a Synaptic Calcium Channel in Drosophila: Intragenic Modifiers of a Temperature-Sensitive Paralytic Mutant of cacophony
... specific calcium chan- Neurotransmitter release is evoked by calcium influx nel gene products at native ...through voltage-gated calcium channels, which triggers work in Drosophila (see ...
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Molecular basis of ion permeability in a voltage gated sodium channel
... and calcium (II) chlo- ride), with the aim of replacing the sodium ions with other mono- valent or divalent ions to enable the detection of anomalous difference ...
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Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders
... metanalysis of five genome-wide linkage scans in 634 affected sibling pairs found a suggestive association between the chromosome region 17p11.2-q12 and ASD, this region comprises CACNB1, however this finding requires ...
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Non voltage gated calcium channels in snail heart ventricle cells
... Channel identity The following summarizes the evidence which suggests that the SG and LG channels may be Ca 2+ channels: 1 the channels conduct Na + only in the absence of Ca 2 + ; 2 the[r] ...
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Identification of Mutation in SCN4A, Hot-Spot for Periodic Paralyses, in a Large Chinese Family with a Typical Normokalemic PP Using the Whole-Exome Sequencing
... a-subunit, voltage-gated sodium channel, ...the voltage sensor and by rotamer conformations of R4 ...while calcium gluconate was ...potassium channel gene such as KCNE3, in which ...
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Migraine and cluster headache – the common link
... CACNA1A: calcium voltage-gated channel subunit alpha1 A; CCH: chronic cluster headache; cGMP: cyclic guanosine monophosphate; cGMP: cyclic guanosine monophosphate; CGRP: calcitonin ...
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Block of T-type calcium channels by protoxins I and II
... with voltage-gated ion channels [18,22] and to be potent inhibi- tors of voltage-gated sodium channels ...Cav3.1 calcium channel ...
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Selectivity Mechanism of the Voltage-gated Proton Channel, H V
... closed conformation. This structure shows that the SF Asp is located in a hydrophobic layer compris- ing two conserved Phe residues, which might prevent water penetration. Presumably, this hydropho- bic region prevents ...
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Article The role of Voltage-Gated Sodium Channel (VGSC) gene mutations in the resistance of Aedes aegypti L. to pyrethroid permethrin in Palembang and Jakarta, Indonesia
... voltage-gated sodium channel is associated with knockdown resistance to permethrin in Aedes aegypti. Martins, A.J.; Lins, R.M.M; Linss, J.G.B.; Peixoto A.A.; Valle, D; Voltage gated sodi[r] ...
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Identification of a novel mutation in the CACNA1C gene in a Chinese family with autosomal dominant cerebellar ataxia
... L-type calcium channel, may be related to ADCA in a Chinese ...first channel-coding gene reported to be involved in ...Potassium channel mutations have been described in SCA13 (MIM: 605259) ...
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