voltage-gated Na+ channel
Presence of two alternative kdr like mutations, L1014F and L1014S, and a novel mutation, V1010L, in the voltage gated Na+ channel of Anopheles culicifacies from Orissa, India
... Presence of two alternative kdr-like mutations, L1014F and L1014S, and a novel mutation, V1010L, in the voltage gated Na+ channel of Anopheles culicifacies from Orissa, India Research.. [r] ...
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Nerve growth factor enhances voltage-gated Na+ channel activity and transwell migration in Mat-LyLu rat prostate cancer cell line
... depolarising voltage pulses between -70 mV and +70 mV applied from a holding potential of -100 mV: (i) a control cell; (ii) a cell pre-treated with 20 ng/ml NGF for 24 ...
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Biophysical properties of voltage gated Na+ channels in frog parathyroid cells and their modulation by cannabinoids
... depolarizing voltage steps from a holding potential of –84·mV ...the voltage-gated outward current could be ...external Na + completely abolished the inward currents (3 cells; ...by Na ...
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Evolution of voltage gated Na+ channels
... sodium channel from human ...novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after ...
10
An evolutionarily unique heterodimeric voltage gated cation channel found in aphids
... TTX-insensitive channel in aphids, we were unable to detect any fingerprints of positive selection for TTX-insensitivity in the aphid channels on comparative analysis of multiple Na v 1 sequence alignments ...
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Mutations in the voltage gated sodium channel gene of anophelines and their association with resistance to pyrethroids – a review
... Despite 15 years of research, some doubts still arise with respect to the kdr mutations, especially if they are indeed correlated with the resistant phenotype. One of the tech- niques adopted to test this association is ...
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Designing a C84 fullerene as a specific voltage gated sodium channel blocker
... ion channel could lead to a new set of drug leads for the treatment of various ion channel-related ...bacterial voltage-gated sodium channel (Na v ...
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Perspective The gp91 phox Component of NADPH Oxidase Is Not a Voltage-gated Proton Channel
... 10 nA in some cells, they did not ex- hibit the droop characteristically observed during large H currents (DeCoursey, 1991; Demaurex et ...1996). Voltage-gated proton channels do not inactivate, but ...
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Molecular basis of ion permeability in a voltage gated sodium channel
... NavMs channel has previously been shown to exhibit a signifi- cant selectivity for Na + over K + (Ulmschneider et al, ...NavMs channel (Fig 1 and Appendix Fig S1A, Table 1A). Voltage-dependent ...
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An evolutionarily unique heterodimeric voltage gated cation channel found in aphids
... TTX-insensitive channel in aphids, we were unable to detect any fingerprints of positive selection for TTX-insensitivity in the aphid channels on comparative analysis of multiple Na v 1 sequence alignments ...
10
Aspartate 112 is the selectivity filter of the human voltage-gated proton channel
... The Cl – permeability of D112H was completely unexpected, given strong precedents for His imparting proton selectivity to channels. Histidine shuttles protons in K 1 or Na 1 channel VSDs with ArgRHis ...
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pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1
... the channel is perfectly selective [31,32], which suggests that protons permeate proton channels by a hydrogen- bonded chain mechanism [33] that does not require a continuous aqueous ...the voltage-sensing ...
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Proteomics identification of radiation-induced changes of membrane proteins in the rat model of arteriovenous malformation in pursuit of targets for brain AVM molecular therapy
... Our previous proteomics investigation of the murine endothelial cerebral cell cultures (bEnd3) revealed a large number of membrane proteins that were differentially expressed between irradiated and non-irradiated cells ...
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Structural characterisation of recombinant and synthetic voltage-gated potassium channel domains
... the channel protein, in a “ball and chain” ...B channel was shown to be ablated by trypsin treatment, and the N-terminal region in particular was shown to contain several possible trypsin cleavage sites ...
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Molecular and genetic basis of sudden cardiac death
... Congenital LQTS. The QT interval measured by standard surface ECG provides a surrogate measurement of the average ventricu- lar action potential duration. Both a prolonged or shortened QT interval indicates an increased ...
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Multiple mechanisms mediating carbon monoxide inhibition of the voltage-gated K+ channel Kv1.5
... of channel inhibition because residual inhibition caused by CO in the presence of SOD mimetics, NO or sGC inhibition or in the presence of FeTPPS to scavenge ONOO − was not associated with a slowing of ...
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Identification of Mutation in SCN4A, Hot-Spot for Periodic Paralyses, in a Large Chinese Family with a Typical Normokalemic PP Using the Whole-Exome Sequencing
... a-subunit, voltage-gated sodium channel, ...the voltage sensor and by rotamer conformations of R4 ...potassium channel gene such as KCNE3, in which mutations are a rare cause of ...
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Functional characterization of a voltage gated anion channel from teleost fish intestinal epithelium
... Discussion The goby basolateral membrane union channel is unlike the Cl~ channel in other epithelia At least three pathways for chloride exit exist in the basolateral membrane of teleost[r] ...
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Construction and validation of a homology model of the human voltage-gated proton channel hH 1
... Specifically, we examine the conformational fluctua- tions of residues located at the narrowest part of the channel (Fig. 7) and the time-averaged probability dis- tribution of water along the mean axis of the ...
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A mutation in the low voltage-gated calcium channel CACNA1G alters the physiological properties of the channel, causing spinocerebellar ataxia
... in voltage sensing. Since simultaneous activation of all four voltage sensors is required to open the calcium channel, the arginine residue mutated in the affected individuals is ...
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