Voltage-gated potassium channel
Multicentric Castleman’s disease with voltage-gated potassium channel antibody-positive limbic encephalitis: a case report
... The constellation of subacute encephalopathy, temporal lobe seizures, and mild lymphocytic CSF pleocytosis raised the possibility of autoimmune encephalitis. Serological analysis revealed elevated ...
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Molecular cloning of a glibenclamide sensitive, voltage gated potassium channel expressed in rabbit kidney
... encode voltage-gated potassium channels ...predominant potassium conductance of the kidney medullary cell line GRB-PAP1 is composed of Shaker-like potassium ...Shaker-related ...
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Voltage-Gated Potassium Channel KV1.5 Protects against MPP+ Mediated Neurotoxicity in PC12 Cells
... that voltage-gated potassium channel (Kv) played significant roles in cellular signaling in both excitable and non-excitable ...important voltage-gated K + channel, which ...
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MRI Findings in Autoimmune Voltage Gated Potassium Channel Complex Encephalitis with Seizures: One Potential Etiology for Mesial Temporal Sclerosis
... Autoimmune voltage-gated potassium channel complex encephalitis is frequently manifested as enlargement, T2 hy- perintensity, enhancement, and restricted diffusion of the mesial temporal lobe ...
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Excessive Blinking and Ataxia in a Child With Occult Neuroblastoma and Voltage-Gated Potassium Channel Antibodies
... and voltage- gated potassium channel complex antibodies were detected in ...Although voltage-gated potassium channel complex autoimmunity has not been described ...
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Structural characterisation of recombinant and synthetic voltage-gated potassium channel domains
... the channel protein, in a “ball and chain” ...B channel was shown to be ablated by trypsin treatment, and the N-terminal region in particular was shown to contain several possible trypsin cleavage sites ...
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Limbic Encephalitis Associated with Voltage Gated Potassium Channel Complex Antibodies: Patient Report and Literature Review
... Background: The family of disorders associated with antibodies against neu- ronal surface antigens is a rapidly expanding category of autoimmune neuro- logic disease. Methods: Clinical and laboratory findings of a ...
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Neurological diseases associated with autoantibodies targeting the voltage-gated potassium channel complex: immunobiology and clinical characteristics
... the potassium/sodium hyperpolarization‑activated cyclic nucleotide‑gated ion channel 2 (HCN2), that is an inward rectifying channel acting as a regulator of nociceptive ...
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Silencing of voltage-gated potassium channel K 9.3 inhibits proliferation in human colon and lung carcinoma cells
... various potassium channels are involved in cancer cell proliferation [29, 35, 36, ...several potassium channels have shown anti-proliferative effect in vitro as well as in vivo system, most of them ...
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A missense mutation in the Kv1 1 voltage gated potassium channel–encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia
... Kv1.1 channel subunits can assemble with other Kv channel subunits to form heterotetramers ...mutated channel subunits, leading to a dominant negative effect by the ...tertiary channel ...
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Inhibition of T Cell and Stimulation of B Cell Proliferation by Restraint Stress Mediated by Voltage Gated Potassium Channel 1 3 Expression
... regulated by a small number of ion channels, even the opening of individual ion channel [39]. It suggests that although the K + current is too low to record in lymphocytes by patch clamp, alterations of K + ...
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Adenovirus mediated expression of a voltage gated potassium channel in vitro (rat cardiac myocytes) and in vivo (rat liver) A novel strategy for modifying excitability
... Excitability is governed primarily by the complement of ion channels in the cell membrane that shape the contour of the action potential. To modify excitability by gene transfer, we created a recombinant adenovirus ...
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In silico structure analysis of potassium channel Bgk toxin and its docking prediction with human voltage gated potassium (Kv) channel
... Docking is a method which predicts the favored orientation of one molecule to a second when bound to each other to form a stable complex [22]. Knowledge of the favored orientation in turn may be applied to predict the ...
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Immunotherapy Responsive Autoimmune Subacute Encephalitis: A Report of Two Cases
... 2]. Voltage-gated potassium channel antibody (VGKCAb)-associated encephalitis is a paraneoplastic or nonparaneoplastic disorder charac- terized by amnesia, delirium, and seizures with good ...
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Kv1.3 In Microglia: Neuroinflammatory Determinant and Promising Pharmaceutical Target
... Microglial cells are responsible for brain immunosurveillance. These cells maintain brain homeostasis, phagocytose cellular debris, present antigens to T-lymphocytes and secrete cytokines and chemokines. Upon activation, ...
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Autoimmune encephalitis: a case series and comprehensive review of the literature
... described including anti-LGI1 encephalitis previously termed anti-voltage-gated potassium channel ‘‘anti-VGKC’’ antibody encephalitis and antiN-methyl-D-aspartic acid receptor anti-NMDAR[r] ...
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The role of voltage-gated potassium channels in the regulation of mouse uterine contractility
... BK channel expression in myometrium in a number of species [11], and the expression of BK may be regulated by the hormo- nal environment and/or reproductive state of the animal ...
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Hypoxic pulmonary vasoconstriction: role of voltage-gated potassium channels
... Kv channel inhibi- tion, and the mechanisms of hypoxia-induced inhibition of potassium currents in oxygen-sensitive cells may be ...Kv channel function by the fol- lowing mechanisms: inhibiting ...
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Proteomics identification of radiation-induced changes of membrane proteins in the rat model of arteriovenous malformation in pursuit of targets for brain AVM molecular therapy
... target potassium channels in animal tumour models and in clinical trials; they have also been used for the treatment of other diseases such as type 2 diabetes and hypertension, with minimal side effects ...with ...
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An evolutionarily unique heterodimeric voltage gated cation channel found in aphids
... with potassium channels prior to the availability of any sodium channel crystal structures (for a detailed comparison see Supplementary data ...DEKA channel shows classic interactions with known ...
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