Voltage-gated sodium channel
Regulation of voltage-gated sodium channel expression in cancer : hormones, growth factors and auto-regulation
... the voltage-gated sodium channel showing the main regulatory ...main voltage-sensitive region; the loop between transmembrane segments 5 and 6 is negatively charged and forms the pore ...
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Presence of the point mutations Val1016Gly in the voltage gated sodium channel detected in a single mosquito from Panama
... the voltage-gated sodium channel (VGSC) protein, which causes a re- duction of the binding with the insecticide and, con- sequently, the loss of its effect [14 – ...
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Detection and quantitation of copy number variation in the voltage gated sodium channel gene of the mosquito Culex quinquefasciatus
... Insecticide resistance is typically associated with alterations to the insecticidal target-site or with gene expression variation at loci involved in insecticide detoxification. In some species copy number variation ...
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Article The role of Voltage-Gated Sodium Channel (VGSC) gene mutations in the resistance of Aedes aegypti L. to pyrethroid permethrin in Palembang and Jakarta, Indonesia
... voltage-gated sodium channel is associated with knockdown resistance to permethrin in Aedes aegypti. Martins, A.J.; Lins, R.M.M; Linss, J.G.B.; Peixoto A.A.; Valle, D; Voltage gated sodi[r] ...
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Thermal melt circular dichroism spectroscopic studies for identifying stabilising amphipathic molecules for the voltage gated sodium channel NavMs
... NavMs voltage-gated sodium channel in different amphipols and detergents as a means of identifying amphipathic environments that maximally maintain the protein structure whilst providing a ...
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Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit
... The voltage-gated sodium channel b2 subunit (Navb2) is a physiological substrate of BACE1 (b-site APP cleaving enzyme) and g-secretase, two proteolytic enzymes central to Alzheimer ’ s disease ...
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Molecular dynamics of ion transport through the open conformation of a bacterial voltage gated sodium channel
... voltage-gated sodium channel pore from Magnetococcus ...the channel ’ s full ion translocation pathway and conduc- tance process, selectivity, electrophysiological characteristics, and ...
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Knockdown resistance (kdr) of the voltage gated sodium channel gene of Aedes aegypti population in Denpasar, Bali, Indonesia
... Consequently, the high usage of insecticides has gener- ated dependency of these compounds for regular vector control activities mainly during wet seasons. More import- antly, Ae. aegypti resistance to common used ...
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Designing a C84 fullerene as a specific voltage gated sodium channel blocker
... ion channel could lead to a new set of drug leads for the treatment of various ion channel-related ...bacterial voltage-gated sodium channel (Na v ...
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Contribution of voltage-gated sodium channel β-subunits to cervical cancer cells metastatic behavior
... 30]. Sodium currents of native or transiently trans- fected CeCa cells were recorded at room temperature (20–23 °C) using an Axopatch 200B amplifier, a Digi- data 1320A/D converter, and the pCLAMP ...for ...
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Molecular basis of ion permeability in a voltage gated sodium channel
... as sodium, and those with smaller radii ...the sodium binding sites in the AB and CD ...the channel (Appendix Fig S7A), again consistent with the electrophysiology ...As sodium is the smallest ...
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Human voltage gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents
... unusual sodium currents that have not previously been implicated in disorders of ...neuronal sodium channel ...muscle sodium channel ...cardiac sodium channel ...resurgent ...
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Therapeutic value of voltage-gated sodium channel inhibitors in breast, colorectal and prostate cancer : a systematic review
... Twenty-four studies met the inclusion criteria and attained high quality scores ( ≥ 3/5). Two were clinical drug trials, one of which was conducted in 1993 at a time when VGSC expression in cancer cells was not yet ...
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Structure of a bacterial voltage gated sodium channel pore reveals mechanisms of opening and closing
... bacterial sodium channel was determined 1 , which was in a hybrid conformation: the pore was closed at its cytoplasmic end, thus having no continuous pathway for ions to cross the membrane, but the VS was ...
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Interactions of pyrethroids with the voltage-gated sodium channel. PhD thesis, University of Nottingham
... Maximum channel opening can be achieved by repetitive pulsing (section 5.2.2) and, therefore, the percentage of 1874M channels and para wild type channels modified by deltamethrin was ca[r] ...
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In Vivo Evidence for Voltage-Gated Sodium Channel Expression in Carcinomas and Potentiation of Metastasis
... that voltage-gated sodium channels (VGSCs) are expressed de novo in several human carcinomas where channel activity promotes a variety of cellular behaviours integral to the metastatic ...
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Mutations in the voltage gated sodium channel gene of anophelines and their association with resistance to pyrethroids – a review
... So far, kdr mutations have already been detected in at least 13 species Anopheles gambiae, Anopheles arabiensis, Anopheles sinensis, Anopheles stephensi, Anopheles subpictus, Anopheles s[r] ...
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Voltage gated sodium channels as targets for pyrethroid insecticides
... the voltage-gated sodium ...the channel is affected by amino acid substitu- tions that give rise to resistance has helped to elucidate the mode of action of the compounds and the molecular ...
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Mutations in sodium channel gene SCN9A cause a spectrum of human genetic pain disorders
... More recent genetic studies have identified the voltage-gated sodium-channel Nonstandard abbreviations used: CIP, channelopathy-associated insensitivity to pain; DRG, dorsal root ganglio[r] ...
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Establishment of an innovative and sustainable PCR technique for 1534 locus mutation of the knockdown resistance (kdr) gene in the dengue vector Aedes albopictus
... the voltage‑gated sodium channel (VGSC) gene, or knockdown resistance (kdr) gene, is an important resistance mechanism against DDT and pyrethroids for dengue vector Aedes ...
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