von Willebrand factor
Structural basis of von Willebrand factor binding to platelet glycoprotein Ib and collagen Effects of disulfide reduction and limited proteolysis of polymeric von Willebrand factor
... von Willebrand factor (vWF) is a large, multimeric glycoprotein that helps platelets adhere to vascular subendothelium. Although vWF binding to platelet receptors and connective tissue constituents ...
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Superiority of the Rapid Von Willebrand Factor (VWF) VWF:GPIbR and VWF:GPIbM Assays in Type 2A, 2B and 2M Von Willebrand Disease
... Figure 2. Assay principles of different von Willebrand Factor GPIb-binding activity kits [8-11]. Left: VWF: GPIbR (HemosIL – VWF:RCo Werfen) involves binding of plasma VWF to recombinant ...
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The Effects of Ristocetin and von Willebrand Factor on Platelet Electrophoretic Mobility
... of von Willebrand ...the von Willebrand factor acts as a bridge between ...and von Willebrand factor, singly and together, on the electrophoretic mobility of ...
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Genetic linkage of two intragenic restriction fragment length polymorphisms with von Willebrand's disease type IIA Evidence for a defect in the von Willebrand factor gene
... human von Willebrand factor (vWF) cDNA probes, have been described ...with von Willebrand's disease (vWD) type IIA in a comprehensive, affected ...
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On the miscellaneous aspects of von Willebrand factor
... Von Willebrand factor (VWF) is a glycoprotein circulating in plasma as large multim- ers. When activated upon vascular damage VWF serves as an adhesion molecule for platelets thereby initiating ...
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Comorbidities associated with higher von Willebrand factor (VWF) levels may explain the age-related increase of VWF in von Willebrand disease
... At inclusion in the study, plasma levels of VWF:Ag, VWF col- lagen binding capacity (VWF:CB), VWF activity (measured by the VWF monoclonal antibody assay; VWF:Ab) and FVIII coagulant activity (FVIII:C) were centrally ...
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Studies of the human factor VIII/von Willebrand factor protein III Qualitative defects in von Willebrand's disease
... VIII/von Willebrand factor protein had markedly reduced von Willebrand factor activity in a ristocetin ...of Factor VIII/von Willebrand factor ...
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Substructure of human von Willebrand factor
... Using electron microscopy, we have visualized the substructure of human von Willebrand factor (vWf) purified by two different approaches. vWf multimers, which appear as flexible strands varying in ...
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Carbohydrate of the Factor VIII/von Willebrand Factor in von Willebrand's Disease
... plasma Factor VIII/von Willebrand factor (FVIII/vWF) molecule from 16 patients with von Willebrand's disease, and have found no evidence of a significant decrease of carbohydrate ...
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Subunit composition of plasma von Willebrand factor Cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease, but minimal in variants with aberrant structure of individual oligomers (types IIC, IID, and IIE)
... plasma von Willebrand factor (vWF) and found evidence that cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease (vWD), but decreased or absent in ...
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von Willebrand factor binds to platelets and induces aggregation in platelet type but not type IIB von Willebrand disease
... Platelet-type von Willebrand disease (vWD) and pseudo-vWD are two recently described intrinsic platelet defects characterized by enhanced ristocetin-induced agglutination in platelet-rich ...a von ...
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Human von Willebrand factor/factor VIII concentrates in the management of pediatric patients with von Willebrand disease/hemophilia A
... containing von Willebrand factor (VWF) and factor VIII (FVIII) are currently ...of von Willebrand disease, in whom other treat- ments are ineffective or ...
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Type IIB von Willebrand factor with normal sialic acid content induces platelet aggregation in the absence of ristocetin Role of platelet activation, fibrinogen, and two distinct membrane receptors
... purified von Willebrand factor (vWF), obtained from unrelated patients affected by type IIB von Willebrand disease, were found to have normal sialic acid content (between 129 and 170 ...
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Interaction of von Willebrand factor with human platelets in the plasma milieu
... The binding of von Willebrand factor (vWf) to stimulated platelets in the plasma milieu was performed using a radiolabeled monoclonal antibody to vWf. Plasma proteins specifically inhibited the ...
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Aberrant multimeric structure of von Willebrand factor in a new variant of von Willebrand's disease (type IIC)
... described von Willebrand's disease patients. The larger multimers of von Willebrand factor were lacking both from plasma and platelets, and did not appear in the circulation after infusion of ...
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Disulfide Bonds and the Quaternary Structure of Factor VIII/von Willebrand Factor
... chromatography and 4% agarose gel filtration was subjected to sodium dodecyl sulfate gel electrophoresis on gels containing 2% acrylamide and 0.5% agarose. We find a series of multimers of which the apparent molecular ...
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Evidence that the primary binding site of von Willebrand factor that mediates platelet adhesion on subendothelium is not collagen
... of von Willebrand factor to collagen type I and type ...125I-von Willebrand factor to extracellular matrices of endothelial cells, to smooth muscle cells, or to the ...between ...
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Inactivation of human factor VIII by activated protein C Cofactor activity of protein S and protective effect of von Willebrand factor
... endogenous von Willebrand factor, resulting in a complete protection against APC (4 ...severe von Willebrand's disease, we could vary the amount of von Willebrand ...of ...
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Binding of Staphylococcus aureus Protein A to von Willebrand Factor Is Regulated by Mechanical Force
... ABSTRACT Binding of Staphylococcus aureus to the large plasma glycoprotein von Willebrand factor (vWF) is controlled by hydrodynamic flow conditions. Currently, we know little about the molecular ...
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Functional domains on von Willebrand factor Recognition of discrete tryptic fragments by monoclonal antibodies that inhibit interaction of von Willebrand factor with platelets and with collagen
... the von Willebrand factor (VWF) moiety of the Factor VIII-von Willebrand factor complex (FVIII-VWF), one interacting with blood platelets, and one interacting with vessel ...
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