VZV Infection
Varicella-Zoster Virus (VZV) Infection of Neurons Derived from Human Embryonic Stem Cells: Direct Demonstration of Axonal Infection, Transport of VZV, and Productive Neuronal Infection
... of VZV biology in, and its interaction with, human neurons. VZV infects hESC- derived neurons and expresses viral genes ...axonal infection and retro- grade transport of VZV to be shown for ...
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Human Anti-Varicella-Zoster Virus (VZV) Recombinant Monoclonal Antibody Produced after Zostavax Immunization Recognizes the gH/gL Complex and Neutralizes VZV Infection
... alphaherpesvirus. VZV infection is initiated by membrane fusion, an event dependent in part on VZV glycoproteins gH and ...virus infection. One week af- ter immunizing a 59-year-old ...
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A Chickenpox Pneumothorax: A Case Report of Pneumothorax Secondary to VZV Infection
... Although the exact incidence is unknown, the majority of cases with second- ary pneumothorax are those accompanied with VZV pneumonia and smoking. In some cases, however, there is no examination or radiological ...
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Insights into the role of immunosenescence during varicella zoster virus infection (shingles) in the aging cell model
... data, VZV infection was found to induce an approximately 2-fold higher number of DEGs in HG8 fibroblasts than in HG3 and HG5 fibroblasts, as shown by Venn diagram and IPA analysis, although many of the DEGs ...
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Varicella-Zoster Virus (VZV) ORF17 Protein Induces RNA Cleavage and Is Critical for Replication of VZV at 37oC but Not 33oC
... culture, VZV infection occurs more slowly, and therefore rapid shutoff of host protein synthesis could be det- rimental for virus ...that infection of cells with VZV would not result in rapid ...
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Human Embryonic Stem Cell-Derived Neurons Are Highly Permissive for Varicella-Zoster Virus Lytic Infection
... between VZV and human neurons in vitro. Several papers have described VZV infection in these neurons, including studies with live attenuated vaccine Oka (VOka) VZV, which rarely shows ...
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Impact of Varicella-Zoster Virus on Dendritic Cell Subsets in Human Skin during Natural Infection
... the infection of specific DC subtypes during natural cutaneous VZV ...in VZV-infected skin epidermis compared to that in uninfected skin, extending an earlier case report of CD1a ex- pression in ...
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Abortive Intrabronchial Infection of Rhesus Macaques with Varicella-Zoster Virus Provides Partial Protection against Simian Varicella Virus Challenge
... of VZV infection, including varicella, immunity, latency, and reactiva- ...of VZV, recapitulates virologic and immunologic hallmarks of VZV infection in ...that VZV is acquired ...
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Productive Varicella-Zoster Virus Infection of Cultured Intact Human Ganglia
... of VZV with ganglionic cells, which play a critical role in viral patho- genesis, can be studied in the context of intact DRG, using in vitro cell culture ...of VZV with these ...productive VZV ...
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Neutralizing Anti-gH Antibody of Varicella-Zoster Virus Modulates Distribution of gH and Induces Gene Regulation, Mimicking Latency
... cell-to-cell infection, resulting in a single infected cell without apoptosis or necrosis, and the number of infectious cells in cultures treated with anti-gH-MAb declined to undetectable levels in 7 to 10 ...
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Fatal visceral disseminated varicella zoster infection during initial remission induction therapy in a patient with lupus nephritis and rheumatoid arthritis—possible association with mycophenolate mofetil and high dose glucocorticoid therapy: a case report
... agent was withdrawn, but the clinical symptoms and laboratory abnormalities rapidly worsened. Thrombotic microangiopathy associated with SLE was suspected, and additional glucocorticoid pulse therapy together with ...
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Evaluation of Efficacy of Varicella Vaccine in Pediatric Patients with Acute lymphoblastic Leukemia
... children. VZV infections in this patient cohort have an increased risk of serious morbidity and even death ...that VZV vaccination should not be undertaken in children with ...by VZV infection ...
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Varicella-Zoster Virus ORF63 Inhibits Apoptosis of Primary Human Neurons
... of VZV-infected human neurons. A well-characterized cell-associated VZV inoculation method was used to infect dissociated human neuronal cultures ...in VZV-infected neurons, prior to VZV ...
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The Varicella-Zoster Virus (VZV) ORF9 Protein Interacts with the IE62 Major VZV Transactivator
... At least one alternative possibility for the function of the ORF9 protein-orchestrated assembly of tegument proteins, in- cluding IE62, on the cellular microtubule network may be that proposed for the axonal transport of ...
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Successful management of visceral disseminated varicella zoster virus infection during treatment of membranous nephropathy: a case report
... (VZV) infection is often experi- enced by patients who are in an immunocompromised ...disseminated VZV (VDVZV) infection is a rare disease with a high mortality rate that occurs in ...
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Multiple regulatory effects of varicella-zoster virus (VZV) gL on trafficking patterns and fusogenic properties of VZV gH.
... alphaherpesvirus; VZV infection is spread almost exclusively via cell membrane ...the VZV system, the gH:gL complex facilitated cell membrane fusion and extensive polykaryon formation in transfected ...
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Varicella-Zoster Virus Downregulates Programmed Death Ligand 1 and Major Histocompatibility Complex Class I in Human Brain Vascular Adventitial Fibroblasts, Perineurial Cells, and Lung Fibroblasts
... in VZV-infected arteries is unknown; how- ever, virus-induced dysregulation of programmed death ligand 1 (PD-L1) may play a ...whether VZV infection of adventitial cells down- regulates PD-L1 showed ...
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Aberrant Virion Assembly and Limited Glycoprotein C Production in Varicella-Zoster Virus-Infected Neurons
... revealed VZV DNA, transcripts, and proteins corresponding to the VZV immediate early, early, and late kinetic phases of ...late VZV glycoprotein C (gC) open reading frame 14 (ORF14) and (ii) ...
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Varicella-Zoster Virus Pathogenesis and Immunobiology: New Concepts Emerging from Investigations with the SCIDhu Mouse Model
... that VZV can be transferred to skin from respiratory sites of inoculation by tonsillar T cells, VZV-infected tonsil T cells were given to SCID mice with human skin xenografts via intravenous injec- tion ...
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Exposure rate of VZV among women attending antenatal care clinic in Sri Lanka a cross sectional study
... the VZV infections are common in adolescents and adults ...acquiring VZV infection due to late sero-conversion to anti-VZV IgG and thus experiencing morbidity and a mortality rate of up ...to ...
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