Willin expression induced phosphorylation of Hippo pathway . 71
Willin, an upstream component of the Hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts
... fibroblasts. Willin is an upstream component of the Hippo signaling pathway, which results in the inactivation of the transcriptional co- activator YAP through Ser127 ...the expression of ...
15
Willin as a novel 4 1 ezrin radixin moesin (FERM) domain protein in the mammalian hippo signalling pathway
... of willin-GFP was then induced with 1µg/ml tetracycline, and flu- orescence was monitored over a 48 hour time ...the expression of the Mito-DsRed and B) under brightfield ...and willin ...
221
Analysis of the role of the Hippo pathway in cancer
... YAP1 expression, the ectopic expression of YAP1 promotes anchorage dependence or independent colony ...the expression of C-fos induced by serum/EGF in GC cells ...The expression of YAP1 ...
17
The Role of Hippo Pathway in Mitosis and Cancer
... mitotic phosphorylation of Ajuba by CDK1 is critical for its biological function, suggesting that there is a link between the role of Ajuba in cancer and its mitotic regulation and that Ajuba may exert its role in ...
104
The Hippo Pathway Regulates Hematopoiesis in Drosophila melanogaster
... Next, given that wts loss led to premature induction of crystal cells, as well as ectopic crystal cells in lymph gland regions that normally only harbor progenitor cells, we considered the pos- sibility that Yki and Sd ...
8
Histone Acetylation-Mediated Regulation of the Hippo Pathway
... The Hippo pathway is a signaling cascade recently found to play a key role in tumorigenesis therefore understanding the mechanisms that regulate it should open new opportunities for cancer ...this ...
12
Hippo/YAP signaling pathway is involved in osteosarcoma chemoresistance
... doxorubicin induced YAP activation in MG63 and U2OS osteosarcoma cells To further investigate the role of the Hippo/YAP pathway in osteosarcoma chemoresistance, we evaluated LATS1/2 total protein ...
8
The role of Hippo signal pathway in breast cancer metastasis
... the HIPPO signaling pathway The Hippo signaling pathway is present ubiquitously in mammals, and its activity is strictly ...regulated. Hippo pathway activation is triggered by ...
9
Original Article MST1 inhibits cell proliferation and invasion of non-small-cell lung cancer by regulating YAP phosphorylation and Hippo pathway
... increased expression of CTGF and ...the Hippo pathway in NSCLC ...activate Hippo signaling pathway, and deple- tion of MST1 could inactivate Hippo signaling ...of Hippo ...
8
Phenytoin activates Smad3 phosphorylation and periostin expression in drug-induced gingival enlargement.
... and Banita I.M. (2014). Role of transforming growth factor beta-connective tissue growth factor pathway in dihydropyridine calcium channel blockers-induced gingival overgrowth. Rom. J. Morphol. Embryol. 55, ...
32
MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway.
... was phosphorylation-de- pendent, and to assess whether it was direct, we employed a Far-Western assay ...relative expression levels and immunopurification efficiency, bottom ...the phosphorylation- ...
13
Autopalmitoylation of TEAD Proteins Regulates Transcriptional Output of Hippo Pathway
... the expression of the 2CS mutant or WT Scalloped. Consistently, expression of Yki and WT Scalloped induced the expression of both genes, while expression of Yki and Scalloped 2CS mutant ...
28
Effects of mTOR Inhibitors on Components of the Salvador-Warts-Hippo Pathway
... the Hippo pathway that promotes cell proliferation and epithelial-mesenchymal transition ...[23,24]. Phosphorylation at key residues by Hippo pathway kinases causes retention of TAZ in ...
19
Angiomotins link F-actin architecture to Hippo pathway signaling
... LATS2 phosphorylation of ...LATS2 phosphorylation of YAP to a sim ilar degree, suggesting that F-actin binding m ight not regu- late AM O T130 activation of ...YAP. Expression of different versions ...
11
Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway
... Par3 expression in PCa tissues compared to normal ...Endogenous expression of Par3 is tested by western ...(d) Expression level of Par3 is improved after infection of a lentiviral vector to ...
14
S100A7 induction is repressed by YAP via the Hippo pathway in A431 cells
... YAP expression was also found in suspended and dense cells, the inhibition of YAP activity was confirmed by a decrease in CYR61 ...YAP phosphorylation by suspension and dense culture suggested the ...
10
The Hippo pathway effector Taz is required for cell morphogenesis and fertilization in zebrafish
... core Hippo kinase cascade leads to the phosphorylation of the two transcriptional effectors yes-associated protein (YAP) and transcriptional co- activator with PDZ-binding motif (TAZ) and to their ...
13
The Hippo pathway in colorectal cancer
... the Hippo pathway in the Wnt-related patho- mechanisms of the CRC ...Wnt pathway (Figure ...The expression of the TCF4 transcription factor and the activation of Wnt target genes’ ...
15
The Hippo pathway in normal development and cancer
... The Hippo pathway is a central regulator of organ size and tissue ...homeostasis. Hippo kinases and adaptor proteins mediate the phosphorylation and inactivation of YAP and TAZ, two closely ...
65
The Hippo Signaling Pathway in Development and Cancer
... Baena-Lopez, L.A., Rodrı´guez, I., and Baonza, A. (2008). The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-like. Proc. Natl. Acad. Sci. USA 105, 9645–9650. ...
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