With and Without Systemic Autoimmune Diseases
Validity of clinical associations of biomarkers in translational research studies: the case of systemic autoimmune diseases
... Many early studies of potential biomarkers in systemic autoimmune diseases did not include design features important for valid clinical associations. Greater atten- tion to the design of ...
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A Case Control study to Compare the Prevalence of Periodontal Disease in patients With and Without Systemic Autoimmune Diseases
... Immune mechanism and their effects are similar for both systemic autoimmune diseases and periodontal diseases. This study has been done to evaluate the periodontal condition of ...
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Rates of, and risk factors for, severe infections in patients with systemic autoimmune diseases receiving biological agents off label
... with systemic autoimmune diseases (SAD) has been based on corticosteroids and immunosuppressive agents, although scientific evidence of their efficacy and safety relies prin- cipally on data from ...
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Role of neutrophils in systemic autoimmune diseases
... to autoimmune responses, although not usually considered classic IFNα- producing cells, neutrophils are capable of synthesizing this cytokine and other type I interferons in response to certain stimuli, including ...
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Follistatin like protein 1 is elevated in systemic autoimmune diseases and correlated with disease activity in patients with rheumatoid arthritis
... (HC) without regular medi- cation or chronic drug or alcohol abuse or other chronic disease or acute ...patients without treatment or treated with disease-modifying antirheumatic drugs (DMARDs), biological ...
12
PPP2R2B hypermethylation causes acquired apoptosis deficiency in systemic autoimmune diseases
... with systemic inflammation, manifested by high ...with systemic inflammation, we observed a robust correlation between DAS28 and PPP2R2B ...from systemic inflammation, may modulate PPP2R2B ...
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Reactive lymphoid hyperplasia of the thyroid followed by systemic autoimmune diseases: a case report
... as autoimmune reaction to the thyroid gland were demonstrated, and he was re- vealed to have systemic rheumatic arthritis (Table ...genesity without any tumorous lesion in the residual left lobe of ...
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Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity
... Combined BCR and TLR ligation by nuclear antigens has been shown to induce a synergistic signaling response, mediated by colocalization of TLR9 and antigen internalized through BCR (61–63). Thus, self-antigens able to ...
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BAFF- and APRIL-targeted therapy in systemic autoimmune diseases
... differentiation [49]. Belimumab directly reduces activa- tion of naïve and transitional B cells and indirectly inhibits development of IgD − CD27 + class-switched memory B cells, plasmablasts, and plasma cells. The ...
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B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex
... unknown. Although B cells do not express GARP at baseline, we found that the GARP- TGF-b complex is induced on activated human and mouse B cells by ligands for multiple TLRs, including TLR4, TLR7, and TLR9. GARP ...
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Therapeutic apheresis in autoimmune diseases
... Abstract: Systemic autoimmune diseases based on an immune pathogenesis produce autoantibodies and circulating immune complexes, which cause inflammation in the tissues of various ...these ...
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The genetics of lupus: a functional perspective
... 58. Ramos PS, Williams AH, Ziegler JT, Comeau ME, Guy RT, Lessard CJ, Li H, Edberg JC, Zidovetzki R, Criswell LA, Gaff ney PM, Cunninghame Graham DS, Graham RR, Kelly JA, Kaufman KM, Brown EE, Alarcón GS, Petri MA, ...
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Peripheral NK and B regulatory cell frequencies are altered with symptomatic exacerbation in generalized myasthenia gravis patients
... (HC), 4 men and 6 women, aged 38.50 ± 16.37. All the participants signed the informed consent prior to the enrollment. The study was performed in accordance with the 1964 Declaration of Helsinki (including amendments) ...
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Orbital inflammatory complications of Crohn’s disease: a rare case series
... Other comorbidities included osteopenia, previous erythema nodosum, sinusitis, and a positive lupus anticoagulant result. Her family history included autoimmune hemolytic anemia, GPA, and tuberculosis. In the 4 ...
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Juvenile dermatomyositis: is periodontal disease associated with dyslipidemia?
... for systemic inflammation and associated to disease activity in children [4] and adult patients ...a systemic inflammatory reaction to the presence of microorganisms (aerobic and anaerobic bacteria) in the ...
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Fetal chondrodysplasia punctata associated with maternal autoimmune diseases: a review
... SLE, systemic sclerosis, poly- myositis or rheumatoid arthritis at the initial presentation or during the clinical ...titers without any criteria of MCTD or other defined connective tissue disease usually ...
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Neuromyelitis optica spectrum disorders without and with autoimmune diseases
... with autoimmune thyroid dis- eases, including chronic thyroiditis, Graves’ disease (GD) or benign thyroid tumours ...organ-specific autoimmune diseases patients were auto- immune thyroid ...
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<p>Choroidal thickness changes in systemic lupus erythematosus patients</p>
... In summary, this study using SD-OCT to evaluate the chor- oid in SLE has the largest sample in the literature and was the fi rst to evaluate the effect of systemic comorbidities in the CT of SLE patients. We ...
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Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease
... of systemic lupus erythematosus (SLE) is multifactorial and ...familial autoimmune lymphoproliferative syndrome, but defects in FasL have not yet been ...
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Analysis of DLA-DQB1 and polymorphisms in CTLA4 in Cocker spaniels affected with immune-mediated haemolytic anaemia
... A control population of Cocker spaniels of 9 years old or greater that did not have a history of immune- mediated disease was selected; with the same limitations regarding breed reporting and patient-relatedness appre- ...
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