WKY rat
Delivery of sry1, but not sry2, to the kidney increases blood pressure and sns indices in normotensive wky rats
... Background: Our laboratory has shown that a locus on the SHR Y chromosome increases blood pressure (BP) in the SHR rat and in WKY rats with the SHR Y chromosome (SHR/y rat). A candidate for this Y ...
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Differential baseline expression and angiotensin II stimulation of leukemia-associated RhoGEF in vascular smooth muscle cells of spontaneously hypertensive rats
... In conclusion, the authors have shown different age- related expression levels of RhoGEFs in SHRs and WKY rats; these include the different baseline and stimulated expression of RhoGEFs. In particular, significant ...
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Original Article Regulation of microRNA-214 on vascular smooth muscle cell proliferation and potential treatment effects in hypertension mouse
... Abstract: The over-proliferation of vascular smooth muscle cell (VSMC) is closely correlated with hypertension. Phosphatase and tensin homology deleted on chromosome ten (PTEN) gene negatively regulates PI3K/AKT signal ...
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Increased calcium absorption in prehypertensive spontaneously hypertensive rat Role of serum 1,25 dihydroxyvitamin D3 levels and intestinal brush border membrane fluidity
... hypertensive rat (SHR) compared with Wistar-Kyoto (WKy) ...age-matched WKy controls, we measured direct arterial blood pressure, Ca absorption, and serum 1,25- dihydroxyvitamin D3 [1,25(OH)2D3] ...
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Increased SGLT1 expression in salivary gland ductal cells correlates with hyposalivation in diabetic and hypertensive rats
... to WKY, in spite of the similar plasma glucose concentration, and the reduced salivary ...diabetic WKY and SHR, the glucose concentration was high in the final saliva, despite the expected increase in ...
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Original Article Comparison study on antihypertensive drugs for treatment of pre-hypertension in rats
... period. Longer administration time, slower the progression of BP, and the progression of SBP in the losartan-treated SHRSP groups were sig- nificantly slower after the drug intervention was stopped when compared to the ...
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Identification of Ceruloplasmin as a Gene that Affects Susceptibility to Glomerulonephritis Through Macrophage Function
... to WKY and LEW rat BMDMs, this stimulates WKY macrophages to produce significantly higher levels of proin- flammatory cytokines such as TNFa, which is an important proinflammatory driver in the ...
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Arginine vasopressin altered the expression of monocarboxylate transporters in cultured astrocytes isolated from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats
... BDNF decreases cortical neuronal cell death during post- MCAO ischemia in adult rats [50]. Similarly, BDNF plays a central role in neuronal recovery after cerebral ischemia [51]. Furthermore, 4 weeks after permanent ...
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Exogenous tumour necrosis factor α induces suppression of autoimmune arthritis
... WKY rats secreted high levels of TNFα early after Mtb chal- lenge, and the TNFα secretion then gradually declined with time post-Mtb challenge, showing the reverse association of disease activity/severity vs TNFα ...
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Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease
... in WKY rats ...with WKY endothelium ...do WKY rats ...and WKY TG). We discovered that both transgenic rat models demon- strated the same distribution and immunophenotypic profile of ...
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Alterations in vasomotor systems and mechanics of resistance-sized mesenteric arteries from SHR and WKY male rats following in vivo testosterone manipulation
... both WKY and SHR [49], and animals fed a high-sodium diet have decreased plasma NE in SHR males (33%) and WKY males (50%) after CAST- and T-normalized plasma NE ...to WKY rats could imply vascular ...
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A Superagonistic Monoclonal Antibody for CD28 Ameliorates Crescentic Glomerulonephritis in Wistar-Kyoto Rats
... To investigate the effect of JJ316 on the bias of Treg cells and non-Treg cells, nor- mal WKY rats were injected with three different amounts of JJ316 (0.1, 0.3 and 1 mg per animal) (n = 4–5 in each group). Rats ...
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Original Article miR-29a regulates VSMC cell proliferation and its roles in the pathogenesis of hypertension through targeting PTEN
... and WKY rats was ...with WKY rats, miR-29a, p-AKT, and Ki67 expression was significantly increased, while PTEN levels were obviously declined in the vascular media of SHR ...
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Testosterone influences renal electrolyte excretion in SHR/y and WKY males
... and WKY rats were originally obtained from Harlan Sprague-Dawley (Indianapolis, IN) in 1981 (SHR/hsd and WKY/hsd), and colonies have been maintained at the University of Akron research ...a WKY ...
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Atrial natriuretic factor gene expression in ventricles of rats with spontaneous biventricular hypertrophy
... A subset of Wistar-Kyoto (WKY) rats that spontaneously develops biventricular hypertrophy (BVH) in response to increased cardiac output was evaluated for ventricular expression of the atrial natriuretic factor ...
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Rat epidermal stem cells promote the angiogenesis of full-thickness wounds
... six-week-old rat was sacrificed by cervical dislocation. The back skin of the rat was removed and placed in a 15- ml centrifuge tube with 1% phosphate-buffered saline (PBS; 10010023; Gibco) and then was ...
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STUDY OF ORAL HYPOGLYCEMIC ACTIVITY OF RHIZOMES OF HEMIDESMUS INDICUS R Br IN ALBINO WISTAR RATS
... ABSTRACT: The present study was carried out to evaluate oral hypoglycemic activity of rhizome of Hemidesmus indicus R.Br. in Albino wistar rats. Hemidesmus indicus (Family: Asclepiadaceae) is a commonly known Indian ...
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DIVALENT CATION AND pH DEPENDENCE OF RAT INTRINSIC FACTOR ACTION IN EVERTED SACS AND MUCOSAL HOMOGENATES OF RAT SMALL INTESTINE
... Calcium is required for rat intrinsic factor concentrate RIFC adsorption to everted sacs of rat small intestine or to rat small intestine mucosal homogenate in vitro.. Magnesium can part[r] ...
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RAT MITE DERMATITIS IN CHILDREN
... : Rat mite dermatitis; acariasis caused by tropical rat mite, Liponyssus bacoti Hirst, 1941. : Tropical rat mite attacking man imi St[r] ...
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Use of micro-positron emission tomography with <sup>18</sup>F-fallypride to measure the levels of dopamine receptor-D2 and <sup>18</sup>F-FDG as molecular imaging tracer in the pituitary glands and prolactinomas of Fischer-344 rats
... MRI was performed using a 7.0T (Bruker Optik GmbH, Ettlingen, Germany) small-animal MRI machine. On follow-up 4 and 6 weeks after the pump implantations, small-animal MRI was used to detect the growth of the ...
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