wnt pathway
The Wnt Pathway Target Gene CCND1 Changes Mitochondrial Localization and Decreases Mitochondrial Activity in Colorectal Cancer Cell Line SW480
... drial activity in the tested colon carcinoma cell line. These results are in agreement with the results of others obtained from other cell types. Sakamaki et al. have shown that cy- clin D1 has an influence on the ...
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Roles of renin-angiotensin system and Wnt pathway in aging-related phenotypes
... canonical Wnt/β-catenin signaling is also involved in the aging process. Wnt/β-catenin signaling activity was enhanced in multiple tissues of a klotho-deficient mouse model of accelerated aging ...[64]. ...
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Recent advances on the progressive mechanism and therapy in castration-resistant prostate cancer
... axis pathway (androgen synthesis, androgen receptor splice variants, coactivators of AR and so on), PI3K-AKT pathway, WNT pathway, DNA repair, rearrangement of ETS gene, novel chemotherapy and ...
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<p>Activated Wnt signaling promotes growth and progression of AFP-producing gastric cancer in preclinical models</p>
... Genomes pathway analyses unveiled Wnt signaling as the top enriched can- didate pathway (Figure ...in Wnt-pathway molecular expression and activity were then ...AFP-mediated ...
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WNT signalling pathway in oral lesions
... signalling pathway is one of the fundamental mechanisms that regulate various biological processes such as cell division, migration and fate determination during embryonic development, cell regeneration and ...
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Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function
... the Wnt pathway, we studied the distribution of the Fz1 receptor, which has been well stud- ied and has been related to the Wnt/β-catenin pathway ...
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Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation
... Canonical Wnt signaling promotes synapse formation We found that activation of the canonical Wnt pathway promotes synapse formation based on the evidence that Wnts that activate canonical Wnt ...
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Identification of putative dental epithelial stem cells in a lizard with life long tooth replacement
... canonical Wnt pathway is sufficient to induce quiescent stem cells to form transit-amplifying cells in the mouse intestine and hair follicle (Blanpain et ...the Wnt pathway, to determine ...
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A Wnt1 regulated Frizzled-1/β-Cateninsignaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection
... of Wnt activity, GSK-3b is known to phosphorylate b-catenin at serine or threonine residues of the N terminal region to predispose degradation of b -catenin through ubiquina- tion ...the Wnt pathway ...
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Activation of the basal cell carcinoma pathway in a patient with CNS HGNET-BCOR diagnosis: consequences for personalized targeted therapy
... the WNT pathways are currently being tested in clinical trials and they could become relevant targeted therapies for CNS ...and WNT pathway and provided first evidences for the relevance of arsenic ...
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Genomic insights into Wnt signaling in an early diverging metazoan, the ctenophore Mnemiopsis leidyi
... The lack of certain Wnt pathway components in Mne- miopsis that are present in other non-bilaterians is an intriguing result. For instance, axin is found in Amphi- medon, Trichoplax, Nematostella and ...
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Altering cancer transcriptomes using epigenomic inhibitors
... of WNT target genes via a TCF/ β-catenin/CBP complex is thought to be a major driver of colorectal ...the WNT pathway (by preventing recruit- ment of the co-activator CBP to TCF/β-catenin target ...
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Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis
... the WNT pathway appears to precede localized expression of Wnt genes, suggesting that localized pathway activation is initially regulated by broadly expressed Wnts in conjunction, or in ...
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Increased Wnt and Notch signaling: a clue to the renal disease in Schimke immuno-osseous dysplasia?
... increased Wnt [20–23] and Notch signaling [24–27] as causes of podocyte ...Canonical Wnt pathway activation proceeds via inhibition of β- catenin ubiquitination, saturation of the β-catenin ...
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LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma
... canonical Wnt signalling ...cancers, Wnt pathway mutations are not apparent in neuroblastoma, although previous microarray analyses have implicated deregulated Wnt signalling in high-risk ...
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Original Article Pathway analysis of esophageal squamous cell carcinoma using iTRAQ-based quantitative proteomic approach
... that Wnt signaling pathway was very important dur- ing the development of ...the Wnt signaling pathway of ESCC were list- ed in the KEGG diagram with pathway ID ko04310 (Figure ...
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Original Article Highly expressed DDX10 promotes hepatocellular carcinoma cell proliferation through Wnt/β-catenin signaling
... Abstract: DDX10, a putative DEAD-box RNA helicase gene, is poorly studied in cancer. Our previous study found that DDX10 was significantly up-regulated in hepatocellular carcinoma (HCC). However, the clinical ...
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Estimation of Prognostic Marker Genes by Public Microarray Data in Patients with Ovarian Serous Cystadenocarcinoma
... There were not enough data on patients that contained both LI and 5-year survival rates within the open serous OC dataset. Nonetheless, validation of the equation using an independent cohort can be done in the future. We ...
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6. R.Prakash and S.Anandakumar
... of Wnt/canonical pathway was identified in the development of begin and malignant breast ...of Wnt ligands and decreased activity of Wnt/Ca 2+ pathway (Howe and Brown, 2004; Clevers and ...
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Original Article Topical application of 8DSS induces anagen hair growth in telogenic mouse skin
... Many other signaling pathways are reported to intersect with Wnt/β-catenin signaling to regu- late hDPCs. GSK3β is an important mediator between the Wnt/β-catenin and PI3K/Akt path- ways. GSK3β ...
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